Chronic lymphocytic leukaemia trials in United States

In United States 186 Also abroad 309

186 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Family Study of Lymphoproliferative Disorders
Where
Rochester
Age
18 years to 100 years
People
3,000
Run by
Mayo Clinic
See details and how to joinNCT00626496
Phase 2Taking people
Personalized NK Cell Therapy in CBT
Where
Houston
Age
15 years to 80 years
People
100
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT02727803
Phase 1Taking people
Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies
Where
Bethesda
Age
18 years to 120 years
People
86
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06904066
Phase 1Not yet taking people in United States
huCART19-IL18-CD428z Cells for the Treatment of Patients With HIV With CD19+ Cancers
Where
Philadelphia
Age
18 years and over
People
6
Run by
University of Pennsylvania
See details and how to joinNCT07891468
Phase 1/2Taking people
Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)
Where
Gainesville, Miami, St. Petersburg
Age
Up to 50 years
People
40
Run by
University of Florida
See details and how to joinNCT05322850
Phase 2Taking people
A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Where
Durham, Kansas City, San Francisco, Seattle
Age
18 years to 80 years
People
100
Run by
VA Office of Research and Development
See details and how to joinNCT06520098
Phase 2Taking people
Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma
Where
Seattle
Age
18 years and over
People
30
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06839053
No phaseTaking people
Cancer Experience Registry (CER) for Cancer Patients and Caregivers
Where
Washington D.C.
Age
18 years and over
People
15,000
Run by
Cancer Support Community, Research and Training Institute, Philadelphia
See details and how to joinNCT02333604
No phaseTaking people
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
Where
Bethesda
Age
18 years to 110 years
People
135
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT05724121
No phaseTaking people
Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution
Where
Atlanta, Aurora, Cincinnati, Houston, Milwaukee, Philadelphia
Age
0 years to 38 years
People
30
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT06131801
Phase 2Taking people
Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Where
Seattle
Age
18 years and over
People
20
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT07194980
Phase 1Taking people
Prophylactic DLI-X for Leukemia Relapse After HCT
Where
Tucson
Age
Up to 65 years
People
180
Run by
University of Arizona
See details and how to joinNCT07254793
Phase 2Taking people
A Phase 2 Trial Of The Bruton Tyrosine Kinase Degrader BGB-16673 In Combination With BCL-2 Inhibitor Sonrotoclax For Patients With Treatment-Naive Chronic Lymphocytic Leukemia (CLL)
Where
Houston
Age
18 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07508995
No phaseTaking people
Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer
Where
Chapel Hill
Age
18 years to 120 years
People
15,000
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT01137643
Phase 1/2Taking people
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Where
Boston, Charlotte, Columbus, Hackensack, Houston, New Brunswick, New York, Philadelphia, Pittsburgh, Portland, Providence, Winston-Salem
Age
18 years and over
People
408 worldwide
Run by
AstraZeneca
See details and how to joinNCT06564038 · EU 2024-515034-33-00
No phaseTaking people
A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab
Where
Little Rock, Springdale
Age
1 year to 23 years
People
300
Run by
Arkansas Children's Hospital Research Institute
See details and how to joinNCT07422337
Phase 2Taking people
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Where
Dallas, Denver, East Brunswick, Fargo, Hackensack, La Jolla, Louisville, Rochester, Spokane, Springdale, Torrance
Age
18 years and over
People
490 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT04728893 · EU 2023-504931-42-00
Phase 2Taking people
Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Where
Jacksonville, Rochester, Scottsdale
Age
18 years and over
People
120
Run by
Mayo Clinic
See details and how to joinNCT03516617
Phase 1Taking people
Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma
Where
San Francisco
Age
18 years and over
People
36
Run by
C. Babis Andreadis
See details and how to joinNCT04545762
Phase 1/2Taking people
CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies
Where
Bethesda
Age
3 years to 39 years
People
130
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05442515
Phase 2Taking people
Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases
Where
Seattle
Age
6 months to 65 years
People
54
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06013423
Phase 1/2Taking people
Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)
Where
Chapel Hill, Columbus, Denver, Duarte, Houston, Jacksonville, Los Angeles, Nashville, Portland, Rochester, Valhalla
Age
13 years to 90 years
People
32
Run by
Vironexis Biotherapeutics Inc.
See details and how to joinNCT06533579
Phase 1/2Taking people
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
Where
Boston, Fort Wayne, Seattle, St Louis, Tampa, Westwood
Age
18 years and over
People
258 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06697184 · EU 2024-518829-15-00
Phase 2Taking people
Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 Trial
Where
Seattle
Age
18 years and over
People
20
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT04941716
Phase 2Taking people
CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant
Where
Atlanta, Boston, Duarte
Age
18 years to 75 years
People
216
Run by
City of Hope Medical Center
See details and how to joinNCT06059391