Chronic lymphocytic leukaemia trials in United States

In United States 186 Also abroad 309

186 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Where
Boston, Charlotte, Hackensack, Houston, La Jolla, New York, Rochester, Seattle, Winston-Salem
Age
18 years and over
People
174 worldwide
Run by
AstraZeneca
See details and how to joinNCT06542250
Phase 1/2Not yet taking people in United States
Roginolisib Plus Obinutuzumab + Venetoclax in R/R CLL
Where
Boston
Age
18 years and over
People
40
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT07847957
Phase 3Taking people
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Where
Baton Rouge, Birmingham, Boston, Chapel Hill, Charleston, Charlotte, Chicago, Dayton, Detroit, Durham, East Brunswick, Hackensack, Houston, Irvine, Jacksonville, La Crosse, La Jolla, Los Alamitos, Los Angeles, Miami, Nashville, Newark, New Orleans, New York, Oakland, Palestine, Palo Alto, Philadelphia, Phoenix, Roanake, Rochester, Roseville, San Francisco, Santa Clara, Seattle, Spokane, St Louis, Tacoma, Vallejo, Walnut Creek, Washington D.C., Waukee, Westwood, Winston-Salem
Age
18 years and over
People
500 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06973187 · EU 2025-522860-34-00
Phase 3Taking people
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia
Where
Aurora, Boston, Charlotte, Chicago, Duarte, Durham, Eugene, Jacksonville, Miami, Milwaukee, New Orleans, New York, Omaha, Orange, Palo Alto, Pittsburgh, Rochester, Salt Lake City, Seattle, Tampa, Tyler, Zion
Age
18 years and over
People
500 worldwide
Run by
BeOne Medicines
See details and how to joinNCT07277231 · EU 2025-524366-21-00
Phase 2Taking people
Pirtobrutinib for the Treatment of Elderly Patients With Chronic Lymphocytic Leukemia
Where
Columbus
Age
75 years and over
People
50
Run by
Jennifer Woyach
See details and how to joinNCT07685717
Phase 2Taking people
Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Where
Bethesda
Age
18 years to 85 years
People
75
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT03986034
Phase 4Taking people
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
Where
Charlotte, Columbus, Philadelphia
Age
18 years to 130 years
People
60 worldwide
Run by
AstraZeneca
See details and how to joinNCT06651970
No phaseTaking people
Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment
Where
Portland
Age
18 years and over
People
45
Run by
OHSU Knight Cancer Institute
See details and how to joinNCT06784167
Phase 1Taking people
Chimeric Antigen Receptor Treatment Targeting CD70 (SEVENTY)
Where
Houston
Age
Up to 75 years
People
78
Run by
Baylor College of Medicine
See details and how to joinNCT06345027
Phase 1Taking people
Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation
Where
Duarte
Age
18 years and over
People
23
Run by
City of Hope Medical Center
See details and how to joinNCT06735664
Phase 1Enrolling by invitation
CD19.20.22 CAR T-cells for Patients With Relapsed/Refractory B-Cell Lymphomas
Where
Baltimore
Age
18 years and over
People
15
Run by
University of Maryland, Baltimore
See details and how to joinNCT07168486
Phase 2Not yet taking people in United States
Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome
Where
Seattle
People
52
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT07819396
Phase 2Taking people
Acalabrutinib and Venetoclax With or Without Early Obinutuzumab for the Treatment of High Risk, Recurrent, or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Where
Houston
Age
18 years and over
People
168
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04169737
Phase 2Not yet taking people in United States
Zanubrutinib and Sonrotoclax for the Treatment of Relapsed Chronic Lymphocytic Leukemia /Small Lymphocytic Leukemia, ZeuS-2 Trial
Where
Duarte, Irvine, Newnan
Age
18 years and over
People
44
Run by
City of Hope Medical Center
See details and how to joinNCT07812246
Phase 1Taking people
Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)
Where
Cleveland
Age
18 years and over
People
15
Run by
Paolo Caimi, MD
See details and how to joinNCT07225439
Phase 1Taking people
Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
Where
Atlanta, Baltimore, Boston, Dallas, Milwaukee, Minneapolis, New York, Providence, Tampa
Age
18 years and over
People
135 worldwide
Run by
Imugene Limited
See details and how to joinNCT03666000
Phase 1Taking people
Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)
Where
Houston
Age
12 months to 25 years
People
38
Run by
Baylor College of Medicine
See details and how to joinNCT05010564
Phase 1/2Taking people
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML
Where
Birmingham, Boston, Chapel Hill, Dallas, Duarte, Goodyear, Greenville, Houston, Jacksonville, Lake Success, Morristown, Newnan, New Orleans, New York, Phoenix, Rochester, Scottsdale, Tampa, Zion
Age
12 years and over
People
160 worldwide
Run by
Sellas Life Sciences Group
See details and how to joinNCT04588922
Phase 3Taking people
Study of NX-5948 Versus Pirtobrutinib in R/R CLL/SLL
Where
Fairfax, Fort Wayne, Indianapolis, Macon, Midland, Nashville
Age
18 years and over
People
620
Run by
Nurix Therapeutics, Inc.
See details and how to joinNCT07516093 · EU 2025-524145-27-00
Phase 1Taking people
Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Where
Miami
Age
1 day to 21 years
People
65
Run by
Florida International University
See details and how to joinNCT05857969
No phaseTaking people
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
Where
Akron, Albany, Ann Arbor, Atlanta, Augusta, Austin, Baltimore, Birmingham, Buffalo, Chapel Hill, Chicago, Cleveland, Columbia, Columbus, Dallas, Dayton, Detroit, Fargo, Fort Myers, Fort Worth, Grand Rapids, Greenville, Hackensack, Hollywood, Honolulu, Houston, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Madera, Madison, Marshfield, Memphis, Milwaukee, Minneapolis, Nashville, New Haven, Oakland, Oklahoma City, Omaha, Orlando, Pensacola, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Sacramento, San Antonio, San Diego, San Francisco, Seattle, Sioux Falls, Spokane, St Louis, Tampa, The Bronx, Wilmington, Winston-Salem
Age
6 years to 39 years
People
330 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT05702645
Phase 2Taking people
Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
Where
Ann Arbor, Atlanta, Charlotte, Chicago, Cincinnati, Dallas, Denver, Houston, Kansas City, Los Angeles, Minneapolis, Orange, Philadelphia, Portland, Salt Lake City, San Francisco
Age
7 years to 25 years
People
240
Run by
Etan Orgel
See details and how to joinNCT05082519
Phase 3Taking people
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Where
Anaheim, Baton Rouge, Bethesda, Billings, Cerritos, Fort Myers, Greenville, Houston, Kingwood, Nashville, New Orleans, Palo Alto, Richmond, Saint Augustine, San Marcos, Spokane, West Palm Beach, York
Age
18 years and over
People
737 worldwide
Run by
Loxo Oncology, Inc.
See details and how to joinNCT05254743 · EU 2023-507699-38-00
Phase 2Taking people
Phase 2 Study Of Mosunetuzumab In Patients With Chronic Lymphocytic Leukemia With Positive MRD
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07566364
Phase 2Taking people
Zanubrutinib, Obinutuzumab, Sonrotoclax (BOSon) or BGB-16673, Obinutuzumab, Sonrotoclax (DOSon) in TN CLL/SLL
Where
Boston, New York
Age
18 years and over
People
80
Run by
Massachusetts General Hospital
See details and how to joinNCT06849713