Colorectal cancer: open trials in Brazil

27 open trials have a site in Brazil. Registry data; only the trial team decides who can take part.

NCT06997497
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Fundação Pio XII - Hospital de Câncer de Barretos (Site 0155), Barretos · CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina (Site 0157), Florianópolis · Hospital de Caridade de Ijuí (Site 0150), Ijuí · Associação Hospitalar Beneficente São Vicente de Paulo (Site 0153), Passo Fundo · Hospital Nossa Senhora da Conceição (Site 0156), Porto Alegre · Hospital de Câncer de Recife (Site 0158), Recife · Fundação Faculdade Regional de Medicina de São José do Rio Preto (Site 0159), São José do Rio Preto · COE Ensino e Pesquisa (Site 0151), São José dos Campos · Instituto do Cancer Arnaldo Vieira de Carvalho (Site 0160), São Paulo · IBCC - Núcleo de Pesquisa e Ensino (Site 0154), São Paulo
Registry updated 2026-11-04
NCT06662786
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Fundacao Pio XII, Barretos · Fundacao Universidade de Caxias Do Sul, Caxias do Sul · Fundacao Doutor Amaral Carvalho, Jaú · Hospital Nossa Senhora da Conceicao S A, Porto Alegre · Hospital Santa Izabel, Santa Casa de Misericordia da Bahia, Salvador · Clinica de Hematologia e Oncologia Viver Ltda, Santa Maria · Funfarme Sjrp, São José do Rio Preto · Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo · Fundacao Faculdade de Medicina Instituto do Cancer do Estado de Sao Paulo, São Paulo · Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo · Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitória
Registry updated 2026-11-03
NCT06750094
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Fundacao Pio XII, Barretos · Fundacao Universidade de Caxias Do Sul, Caxias do Sul · Fundacao Doutor Amaral Carvalho, Jaú · Hospital Nossa Senhora da Conceicao S A, Porto Alegre · Hospital Santa Izabel, Santa Casa de Misericordia da Bahia, Salvador · Funfarme Sjrp, São José do Rio Preto · Fundacao Faculdade de Medicina Instituto do Cancer do Estado de Sao Paulo, São Paulo · Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo · Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo · Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitória
Registry updated 2026-11-03
NCT07284849
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Trial Treatment · Phase 3 · Incyte Corporation
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos · Centro de Pesquisas Clinica Reichow, Blumenau · Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba · Oncosite - Centro de Pesquisa Clinica e Oncologia, Ijuí · Clínica de Neoplasias Litoral Ltda., Itajaí · Hospital Bruno Born, Lajeado · Liga Norte-Rio-Grandense Contra o Câncer, Natal · Hospital de Clinicas de Porto Alegre, Porto Alegre · Hgb - Hospital Giovanni Battista - Mae de Deus Center, Porto Alegre · Hospital Moinhos de Vento, Porto Alegre · Irmandade Da Santa Casa de Misericordia de Porto Alegre, Porto Alegre · Hospital das Clínicas FMRP-USP, Ribeirão Preto · NOB - Núcleo de Oncologia da Bahia, Salvador · CEON Pesquisas, São Caetano do Sul · Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, Sao Jose Rio Preto · Icavc - Instituto Do Câncer Arnaldo Vieira de Carvalho, São Paulo
Registry updated 2026-10-30
NCT06820463
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Trial Treatment · Phase 2 · AbbVie
Hospital De Amor /ID# 271874, Barretos · Oncosite - Centro de Pesquisa Clinica em Oncologia /ID# 270147, Ijuí · Hospital Sao Rafael /ID# 271681, Salvador · Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 271651, São José do Rio Preto · Instituto D Or De Pesquisa E Ensino - Regional Sao Paulo /ID# 270546, São Paulo · Nucleo De Pesquisa Clinica Da Rede Sao Camilo /ID# 272311, São Paulo
Registry updated 2026-10-27
NCT06330064
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Trial Treatment · Phase 1/2 · Daiichi Sankyo
Hospital de Cancer de Barretos - Fundacao Pio XII, Barretos · Cepon - Centro de Pesquisas Oncolă"Gicas de Santa Catarina, Florianópolis · Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho, Jaú · Hospital de Clinicas de Porto Alegre, Porto Alegre · Hospital Sao Lucas da PUCRS, Porto Alegre
Registry updated 2026-10-26
NCT07221357
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Trial Treatment · Phase 2/3 · Bristol-Myers Squibb
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos · Centro Integrado de Oncologia de Curitiba, Curitiba · Liga Norte Riograndense Contra o Cancer, Natal · Hospital Sao Lucas da PUCRS, Porto Alegre · Porto Alegre · Instituto de Oncologia Saint Gallen, Santa Cruz do Sul · Faculdade de Medicina de Sao Jose do Rio Preto, São José do Rio Preto · São Paulo · São Paulo
Registry updated 2026-10-23
NCT07811193
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Trial Treatment · Phase 2 · Vividion Therapeutics, Inc.
NAIC - Instituto do Câncer, Bauru · Hospital Araujo Jorge - Associacao de Combate ao Cancer em Goias, Goiânia · Nucleo de Ensino e Pesquisa do Hospital de Clinicas de Ijuí, Ijuí · Fundacao Pio XII - Hospital de Cancer de Barretos, Jaú · Unidade de Pesquisas Clinicas em Oncologia, Pelotas · Hospital Sirio Libanes - Oncology_Sao Paulo, São Paulo · Instituto do Câncer do Estado de São Paulo, São Paulo · Hospital Evangélico de Cachoeiro de Itapemirim, Vitória
Registry updated 2026-10-21
NCT06885034
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Trial Treatment · Phase 1/2 · GlaxoSmithKline
Porto Alegre · São Paulo · Teresina
Registry updated 2026-10-19
NCT07222800
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · Pfizer
Hospital de Clinicas de Porto Alegre, Porto Alegre · Hospital de Câncer de Recife, Recife · Instituto Nacional de Câncer - INCA, Rio de Janeiro · Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul · Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo · Instituto do Cancer Doutor Arnaldo Vieira de Carvalho, São Paulo
Registry updated 2026-10-08
NCT06625775
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Trial Treatment · Phase 1 · TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Liga Contra o Cancer, Natal · FUTTURA Oncologia, Porto Alegre · Hospital Sao Lucas da PUCRS, Porto Alegre · Clinica de Pesquisas e Centro de Estudos Em Oncologia Ginecologica e Mamaria Ltda, São Paulo · Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo · IEPE - Unimed Sorocaba, Sorocaba
Registry updated 2026-10-01
NCT06252649
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Trial Treatment · Phase 3 · Amgen
Fundacao pio xII Barretos, Barretos · Oncoclinicas Belo Horizonte, Barretos · Hospital Sirio Libanes Brasilia, Brasília · Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim · Oncosite - Centro de Pesquisa Clínica em Oncologia Ltda, Ijuí · Clínica de Neoplasias Litoral, Itajaí · Liga Norte Riograndense Contra o Cancer, Natal · Associacao Hospitalar Moinhos de Vento, Porto Alegre · Irmandade Da Santa Casa de Misericordia de Porto Alegre, Porto Alegre · Oncoclinicas Rio de Janeiro S A, Rio de Janeiro · Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto · Fundacao Antonio Prudente AC Camargo Cancer Center, São Paulo · Oncologia Rede D Or, São Paulo · Instituto Brasileiro de Controle do Cancer Ibcc, São Paulo · Instituto Cancer Sao Paulo Icesp, São Paulo · Vencer e Oncoclinica, Teresina
Registry updated 2026-09-03
NCT07797361
Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study
Trial Treatment · Alexandre Vontobel Padoin
Hospital Sao Lucas da PUCRS, Porto Alegre
Registry updated 2026-09-01
NCT05253651
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · Seagen, a wholly owned subsidiary of Pfizer
Instituto De Educação, Pesquisa e Gestão em Saúde - Instituto Américas, Barra da Tijuca · Hospital de Cancer de Barretos - Fundacao Pio XII, Barretos · CIONC-Centro Integrado de Oncologia de Curitiba, Curitiba · Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho, Jaú · Centro Integrado de Pesquisa em Oncologia CIPO-GHC / Hospital Nossa Senhora da Conceicao, Porto Alegre · Institute de Educacao, Pesquisa e Gestao em Saude - Instituto COI, Rio de Janeiro · CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André · Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, São José do Rio Preto · Icesp - Instituto Do Câncer Do Estado de São Paulo Octavio Frias de Oliveira, São Paulo
Registry updated 2026-07-22
NCT07066046
Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions
Trial Treatment · Instituto do Cancer do Estado de São Paulo
Hospital das Clinicas da Faculdade de Medicina da USP, São Paulo
Registry updated 2026-06-23
NCT06808685
Real World Multicenter National Study to Evaluate the Effectiveness and Safety of Biosimilar Bevacizumab Elovie
Research · Libbs Farmacêutica LTDA
Hospital Vera Cruz, Campinas · Centro de Oncologia do Paraná (COP), Curitiba · OncoJaraguá, Jaraguá do Sul · Centro de Pesquisa Unimed Londrina, Londrina · Centro de Pesquisa Unimed Porto Alegre, Porto Alegre · Associacao Hospitalar Moinhos de Vento, Porto Alegre · Instituto Dor de Pesquisa E Ensino, Recife · Unidade de Ensino e Pesquisa UEP-COHM, Santo Ângelo · CEON Pesquisas, São Caetano do Sul · COE Ensino e Pesquisa, São José dos Campos · Instituto Dor de Pesquisa E Ensino, São Paulo · Centro Paulista de Oncologia, São Paulo · Centro de Ensino e Pesquisa - Hospital São Marcos, Teresina · Unimed Vitória, Vitória
Registry updated 2026-06-01
NCT07388953
Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP)
Trial Treatment · Faculdade de Ciências Médicas de Minas Gerais
Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte
Registry updated 2026-02-13
NCT05855200
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Trial Treatment · Phase 3 · GlaxoSmithKline
Barretos · Belém · Campo Grande · Lages · Natal · Porto Alegre · Salvador · São José do Rio Preto · São Paulo · Teresina · Vitória
Registry updated 2026-01-23
NCT04373564
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
Trial Treatment · Phase 4 · Guerbet
Instituto Baía Sul de Ensino e Pesquisa (IEP), Florianópolis · Liga Norte-Rio-Grandense Contra o Câncer, Natal · Instituto Mederi de Pesquisa e Saude, Passo Fundo · Hospital Moinhos de Vento, Porto Alegre · CEMEC - Oncológica, São Bernardo do Campo · Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, São José do Rio Preto · Albert Einstein Sociedade Beneficente Israelita Brasileira, São Paulo · CPCLIN - Centro de Pesquisas Clínicas Ltda., São Paulo · Hospital Santa Marta, Taguatinga
Registry updated 2026-01-22
NCT07285356
Study to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy
Trial Treatment · AC Camargo Cancer Center
A.C. Camargo Cancer Center, São Paulo
Registry updated 2025-12-16
NCT07268846
Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery
Trial Treatment · AC Camargo Cancer Center
A.C. Camargo Cancer Center, São Paulo
Registry updated 2025-12-08
NCT06917794
Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM Project
Research · D'Or Institute for Research and Education
Instituto D'Or de Pesquisa e Ensino, Brasília · Instituto D'Or de Pesquisa e Ensino, Curitiba · Instituto D'Or de Pesquisa e Ensino, Fortaleza · Instituto D'Or de Pesquisa e Ensino, Recife · Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro · CPOC - Centro de Pesquisa Oncológica e Clínica, faz parte do Complexo Associação Obras Sociais lrmã Dulce (AOSID), Salvador · Instituto D'Or de Pesquisa e Ensino, Salvador · Instituto D'or de Pesquisa e Ensino, São Paulo · Instituto do Câncer do Estado de São Paulo, São Paulo
Registry updated 2025-04-08
NCT06793137
Intestinal Microbiome Modulation With Antibiotics in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer
Trial Treatment · Phase 2 · AC Camargo Cancer Center
A.C. Camargo Cancer Center, São Paulo
Registry updated 2025-01-29
NCT06787807
Proteomic Analysis of Patients Undergoing Bariatric Surgery
Trial Treatment · Universidade Federal de Pernambuco
Hospital das clínicas da UFPE, Recife
Registry updated 2025-01-22
NCT02185443
Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases
Trial Treatment · Phase 2 · University of Sao Paulo
Instituto do Câncer do Estado de São Paulo, São Paulo
Registry updated 2024-12-09

All Colorectal cancer trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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