Colorectal cancer: open trials in Germany

104 open trials have a site in Germany. Registry data; only the trial team decides who can take part.

NCT04929223
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Trial Treatment · Phase 1 · Hoffmann-La Roche
Charite Universitaetsmedizin Berlin KöR, Berlin · Katholisches Klinikum Bochum gGmbH, Bochum · Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR, Dresden · Universitaetsklinikum Duesseldorf AöR, Duesseldorf · Asklepios Kliniken Hamburg GmbH, Hamburg · SLK-Kliniken Heilbronn GmbH, Heilbronn · Klinikum der Universitaet Muenchen AöR, Munich · Universitaetsklinikum Ulm AoR, Ulm
Registry updated 2026-11-06
NCT06324357
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Trial Treatment · Phase 1/2 · Boehringer Ingelheim
Universitätsklinikum Carl Gustav Carus Dresden, Dresden · Universitätsklinikum Erlangen, Erlangen · Evang. Kliniken Essen-Mitte gGmbh, Essen · Asklepios Kliniken GmbH & Co. KGaA, Hamburg · Universitätsklinikum Mannheim GmbH, Mannheim · Universitätsklinikum Ulm, Ulm
Registry updated 2026-11-05
NCT07228832
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · Summit Therapeutics
Berlin · Bonn · Hamburg
Registry updated 2026-11-05
NCT07549412
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Trial Treatment · Phase 3 · EMD Serono Research & Development Institute, Inc.
Klinikum St. Marien Amberg, Amberg · Charite Universitaetsmedizin Berlin KöR, Berlin · Katholisches Klinikum Bochum gGmbH, Bochum · Technische Universitaet Dresden, Dresden · Krankenhaus Nordwest GmbH, Frankfurt am Main · Asklepios Kliniken Hamburg GmbH, Hamburg · Haematologisch Onkologische Praxis Eppendorf, Hamburg · Universitaet Leipzig, Leipzig · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Muenchen Klinik gGmbH, Munich
Registry updated 2026-11-05
NCT06997497
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Charite Universitaetsmedizin Berlin KöR, Berlin · KEM I Evang. Kliniken Essen-Mitte gGmbH, Essen · Goethe University Frankfurt, Frankfurt Am Main · Asklepios Kliniken Hamburg GmbH, Hamburg · Katholisches Marienkrankenhaus gGmbH, Hamburg
Registry updated 2026-11-04
NCT07114601
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Trial Treatment · Phase 1 · Eli Lilly and Company
Universitaetsklinikum Erlangen, Erlangen · Universitaetsklinikum - Essen, Essen · Klinikum der Technischen Universitaet Muenchen (TUM Klinikum), München · LMU Klinikum Muenchen-Campus Grosshadern, München
Registry updated 2026-11-04
NCT07213791
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
Trial Treatment · Phase 1 · Eli Lilly and Company
Universitaetsklinikum Essen (AoR), Essen
Registry updated 2026-11-04
NCT05379595
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
Trial Treatment · Phase 1/2 · Janssen Research & Development, LLC
Asklepios Kliniken Hamburg GmbH, Hamburg · Klinikum der Universitaet Muenchen AöR, Munich
Registry updated 2026-11-03
NCT06662786
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR, Dresden · Universitaetsklinikum Essen (AoR), Essen · Krankenhaus Nordwest GmbH, Frankfurt am Main · Praxis Fuer Interdisziplinaere Onkologie And Haematologie GbR, Freiburg Im Breisgau · Asklepios Kliniken Hamburg GmbH, Hamburg · National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Klinikum der Universitaet Muenchen AöR, Munich · Universitaetsklinikum Ulm AoR, Ulm
Registry updated 2026-11-03
NCT06750094
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Charite Universitaetsmedizin Berlin KöR, Berlin · Krankenhaus Nordwest GmbH, Frankfurt am Main · National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Klinikum der Universitaet Muenchen AöR, Munich
Registry updated 2026-11-03
NCT07262619
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Trial Treatment · Phase 1/2 · Eikon Therapeutics
Helios Klinikum Berlin Buch, Berlin · DONAUISAR Klinikum, Deggendorf · Norddeutsches Studienzentrum fur Innovative Onkologie (NIO) Hamatologisch Onkologische Praxis Eppendorf (HOPE), Hamburg
Registry updated 2026-10-30
NCT07284849
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Trial Treatment · Phase 3 · Incyte Corporation
Charite Universitaetsmedizin Berlin KöR, Berlin · Technische Universitaet Dresden, Dresden · Universitaetsklinikum Essen (AoR), Essen · Krankenhaus Nordwest GmbH, Frankfurt am Main · Medical Center- University of Freiburg, Freiburg im Breisgau · University Medical Center Hamburg-Eppendorf, Hamburg · Asklepios Kliniken Hamburg GmbH, Hamburg · Medizinische Hochschule Hannover, Hanover · Universitaetsklinikum Schleswig-Holstein AöR, Luebeck · LMU Klinikum Muenchen AöR, Munich · Muenchen Klinik gGmbH, Munich · Universitaetsklinikum Regensburg AöR, Regensburg
Registry updated 2026-10-30
NCT04421820
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Trial Treatment · Phase 1/2 · Bold Therapeutics, Inc.
Rheinische Friedrich-Wilhelms-Universitaet Bonn, Bonn · Universitaetsklinikum Ulm AoR, Ulm
Registry updated 2026-10-28
NCT07099924
Rectus Sheath Catheters Following Midline Laparotomy
Trial Treatment · Asklepios Kliniken Hamburg GmbH
Asklepios Medical Center Uckermark, Schwedt
Registry updated 2026-10-28
2026-525883-17-00
Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer.
Trial Treatment · Phase 3 · Genmab A/S
Katholisches Klinikum Bochum gGmbH, Bochum · Technische Universitaet Dresden, Dresden · Marien Hospital Duesseldorf GmbH, Duesseldorf · Universitaetsklinikum Essen (AoR), Essen · Universitaetsmedizin Goettingen, Goettingen · Haematologisch Onkologische Praxis Eppendorf / Norddeutsches Studienzentrum für Innovative Onkologie, Hamburg · SLK-Kliniken Heilbronn GmbH, Heilbronn · Universitaet Leipzig, Leipzig · Klinikum der Technischen Universitaet Muenchen (TUM Klinikum), Munich · LMU Klinikum Muenchen AöR, Munich · ohO Research GmbH, Oldenburg in Holstein
Registry updated 2026-10-26
NCT06330064
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Trial Treatment · Phase 1/2 · Daiichi Sankyo
Charite Universitaetsmedizin Berlin KöR, Berlin · Vivantes Netzwerk fuer Gesundheit GmbH, Berlin · Staedtisches Klinikum Dresden, Dresden · Universitaetsklinikum Heidelberg AöR, Heidelberg · SLK-Kliniken Heilbronn GmbH, Heilbronn · Universitaet Leipzig, Leipzig · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Universitaet Muenster, Muenster
Registry updated 2026-10-26
NCT07221357
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Trial Treatment · Phase 2/3 · Bristol-Myers Squibb
Charite Universitaetsmedizin Berlin KöR, Berlin · Katholisches Klinikum Bochum gGmbH, Bochum · Klinikum Chemnitz gGmbH, Chemnitz · Technische Universitaet Dresden, Dresden · Marien Hospital Duesseldorf GmbH, Duesseldorf · Universitaetsklinikum Erlangen AöR, Erlangen · Krankenhaus Nordwest GmbH, Frankfurt am Main · Universitaetsmedizin Goettingen, Goettingen · Haematologisch Onkologische Praxis Eppendorf, Hamburg · Asklepios Kliniken Hamburg GmbH, Hamburg · Onkologie am Raschplatz Dr. Ingo Zander & Dr. Eyck von der Heyde, Hannover · Universitaet Leipzig, Leipzig · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Heidelberg University, Mannheim · Muenchen Klinik gGmbH, Munich · Universitaetsklinikum Ulm AoR, Ulm
Registry updated 2026-10-23
NCT07811193
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Trial Treatment · Phase 2 · Vividion Therapeutics, Inc.
DRK Kliniken Berlin-Köpenick - Darmzentrum, Berlin · Universitaetsklinikum Essen - Innere Klinik (Tumorforschung), Essen · Krankenhaus Nordwest GmbH - Institut Fuer Klinisch-Onkologische Forschung (IKF), Frankfurt am Main · Asklepios Klinik Altona - Onkologie, Hämatologie, Palliativmedizin, Rheumatologie und Pneumologie, Hamburg · Klinikum Oldenburg - Klinik für Onkologie und Hämatologie, Oldenburg · Leopoldina-Krankenhaus der Stadt Schweinfurt GmbH-Medizinische Klinik 2, Schweinfurt · Universitätsklinikum Ulm - Klinik für Innere Medizin I, Ulm
Registry updated 2026-10-21
NCT06607458
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
Trial Treatment · Phase 2 · Delcath Systems Inc.
Asklepios Klinik Altona, Hamburg · Medizinische Hochschule Hannover, Hanover · Helios Park-Klinikum Leipzig, Leipzig
Registry updated 2026-10-20
NCT06885034
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Trial Treatment · Phase 1/2 · GlaxoSmithKline
Bochum · Düsseldorf · Frankfurt am Main · Lübeck · München
Registry updated 2026-10-19
NCT07525206
A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
Trial Treatment · Phase 3 · AbbVie
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Bonn AöR, Bonn · Gemeinschaftspraxis Haematologie Onkologie, Dresden · Universitaetsklinikum Essen (AoR), Essen · Goethe University Frankfurt, Frankfurt Am Main · Asklepios Kliniken Hamburg GmbH, Hamburg · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · LMU Klinikum Muenchen AöR, Munich · Kreiskliniken Reutlingen gGmbH, Reutlingen
Registry updated 2026-10-19
2025-521587-35-00
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with FOLFOX versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer (HARMONi-GI3)
Trial Treatment · Phase 3 · Summit Therapeutics Inc.
Charite Universitaetsmedizin Berlin KöR, Berlin · DRK Kliniken Berlin, Berlin · Johanniter GmbH, Bonn · Technische Universitaet Dresden, Dresden · Universitaetsklinikum Duesseldorf AöR, Duesseldorf · Universitaetsklinikum Essen (AoR), Essen · KEM I Evang. Kliniken Essen-Mitte gGmbH, Essen · Krankenhaus Nordwest GmbH, Frankfurt am Main · Goethe University Frankfurt, Frankfurt Am Main · Hämatologisch Onkologische Praxis Eppendorf (HOPE), Hamburg · Asklepios Kliniken Hamburg GmbH, Hamburg · Medizinische Hochschule Hannover, Hanover · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaetsklinikum Schleswig-Holstein AöR, Luebeck · Philipps-Universitaet Marburg, Marburg · Klinikum der Technischen Universitaet Muenchen (TUM Klinikum), Munich · LMU Klinikum Muenchen AöR, Munich · Klinikum Der Landeshauptstadt Stuttgart gKAöR, Stuttgart · Universitaetsklinikum Ulm AoR, Ulm
Registry updated 2026-10-16
NCT07186842
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Trial Treatment · Phase 1/2 · BioNTech SE
St. Josef-Hospital im Katholischen Klinikum Bochum, Bochum · Klinikum der Universität München, München · Universitaetsklinikum Ulm, Ulm
Registry updated 2026-10-15
2025-521209-42-00
A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer (aCRC) with wild-type RAS and right primary tumour location (right-PTL) - ARIEL-ENGIC 04 EU trial
Trial Treatment · Phase 4 · Fondazione GONO G.I.
Charite Universitaetsmedizin Berlin KöR, Berlin · Krankenhaus Nordwest GmbH, Frankfurt am Main · Muenchen Klinik gGmbH, Munich
Registry updated 2026-10-14
NCT06026410
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
Trial Treatment · Phase 1 · Kura Oncology, Inc.
Charite Universitaetsmedizin Berlin KöR, Berlin · Universitaetsklinikum Ulm AoR, Ulm · Universitaetsklinikum Wuerzburg AöR, Wuerzburg
Registry updated 2026-10-14

All Colorectal cancer trials and the map

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