Colorectal cancer trials in Germany

In Germany 104 Also abroad 1929

104 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer (aCRC) with wild-type RAS and right primary tumour location (right-PTL) - ARIEL-ENGIC 04 EU trial
Where
Berlin, Frankfurt am Main, Munich
Age
18 years and over
People
120 worldwide
Run by
Fondazione GONO G.I.
See details and how to join2025-521209-42-00 · EU 2025-521209-42-00
Phase 1Taking people
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
Where
Berlin, Ulm, Wuerzburg
Age
18 years and over
People
300 worldwide
Run by
Kura Oncology, Inc.
See details and how to joinNCT06026410 · EU 2024-513285-19-00
No phaseTaking people
Hyperthermia With Chemoradiotherapy in Rectal Cancer
Where
Tübingen
Age
18 years and over
People
264
Run by
University Hospital Tuebingen
See details and how to joinNCT06831981
Phase 1Taking people
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Where
Essen
Age
18 years and over
People
180 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07261631
Phase 3Taking people
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Where
Berlin, Dresden, Essen, Frankfurt am Main, Hamburg, Leipzig, Munich
Age
18 years and over
People
800 worldwide
Run by
Pfizer
See details and how to joinNCT07222800 · EU 2025-523521-18-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Augsburg, Essen, Frankfurt am Main, Hamburg, Heidelberg
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Essen, Heidelberg, Herne, Jena, Nuertingen, Tuebingen
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Berlin, Essen, Hanover, München, Regensburg
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
Phase 1/2Taking people
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Where
Cologne, Esslingen am Neckar, Moers, Nuremberg
Age
18 years and over
People
534 worldwide
Run by
Revolution Medicines, Inc.
See details and how to joinNCT06128551
Phase 2Taking people
A pilot study of the safety and tolerability of oral administration of PD L 506 and the subsequent diagnostic value of porphyrin concentration (coproporphyrin I / III, CP I / III) in urine in patients with the first occurrence of colorectal cancer and in healthy subjects.
Where
Essen, Munich
Age
18 years and over
People
30
Run by
Photonamic GmbH & Co. KG
See details and how to join2023-508668-31-00 · EU 2023-508668-31-00
No phaseTaking people
Multicentre Study for Data Collection, Development, and Evaluation of Novel CRC Screening and Diagnostic Methods
Where
Lübeck, Mainz-GE
Age
18 years and over
People
4,100 worldwide
Run by
Firalis SA
See details and how to joinNCT06515821
Phase 1Taking people
A phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-DFC413 and safety and imaging properties of [68Ga]Ga-NNS309 in patients with solid tumors
Where
Essen
Age
18 years and over
People
62 worldwide
Run by
Novartis Pharma AG
See details and how to join2025-521702-18-00 · EU 2025-521702-18-00
No phaseTaking people
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
Where
Hamburg, Heilbronn, Munich
Age
18 years and over
People
2,285 worldwide
Run by
Guardant Health, Inc.
See details and how to joinNCT05059444
Phase 1/2Taking people
Safety of HRX215 in Patients After Minor and Major Liver Resection
Where
Essen, Tübingen
Age
18 years to 75 years
People
80 worldwide
Run by
HepaRegeniX GmbH
See details and how to joinNCT06638502
No phaseNot yet taking people in Germany
Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options
Where
Berlin
Age
18 years to 65 years
People
260
Run by
Charite University, Berlin, Germany
See details and how to joinNCT07811453
No phaseTaking people
Fruquintinib in Patients With Metastatic Colorectal Cancer
Where
Aschaffenburg, Berlin, Biberach, Cologne, Cottbus, Dresden, Essen, Frechen, Freiburg im Breisgau, Fürth, Goslar, Hamburg, Hanover, Heidelberg, Hof, Idar-Oberstein, Landshut, Lebach, Leer, München, Naunhof, Neustadt am Rübenberge, Potsdam, Ratingen, Ravensburg, Regensburg, Rosenheim, Schorndorf, Soest, Speyer, Stolberg, Ulm, Weinheim, Wermelskirchen, Wilhelmshaven, Zittau
Age
18 years and over
People
150
Run by
iOMEDICO AG
See details and how to joinNCT06787105
Phase 3Taking people
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Where
Berlin, Chemnitz, Dresden, Essen, Frankfurt am Main, Hamburg, Ludwigsburg, München, Ulm, Wolfsburg
Age
18 years and over
People
450 worldwide
Run by
Amgen
See details and how to joinNCT06252649
No phaseTaking people
Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
Where
Berlin, Cologne, Dresden, Ulm, Würzburg
Age
18 years and over
People
48
Run by
Technische Universität Dresden
See details and how to joinNCT05652348
No phaseTaking people
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery
Where
Dresden
Age
18 years and over
People
12
Run by
Technische Universität Dresden
See details and how to joinNCT05652361
No phaseTaking people
Social Prescriptions and Micro-Learning to Improve Care for Cancer Patients and Their Support Persons
Where
Augsburg, Bayreuth, Berlin, Cologne, Erlangen, Regensburg, Würzburg
Age
18 years and over
People
384
Run by
University of Regensburg
See details and how to joinNCT07788729
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Dresden, Essen, Frankfurt, Ulm, Würzburg
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709
Phase 3Taking people
Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)
Where
Berlin, Chemnitz, Dresden, Essen, Frankfurt am Main, Hamburg, Ludwigsburg, Munich, Ulm, Wolfsburg
Age
18 years to 64 years
People
241 worldwide
Run by
Amgen Inc.
See details and how to join2022-502352-31-00 · EU 2022-502352-31-00
Phase 1Taking people
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
Where
Essen
Age
18 years and over
People
434 worldwide
Run by
Amgen
See details and how to joinNCT07094113
Phase 1Taking people
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Where
Cologne, Essen, München, Rostock
Age
18 years to 100 years
People
162 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06562192
Phase 3Not yet taking people in Germany
Continuous or Intermittent Cetuximab Plus FOLFIRI as First-line Treatment in RAS/BRAF Wild-type mCRC Patients
Where
Amberg, Augsburg, Bad Saarow, Bayreuth, Berlin, Bochum, Bremen, Cologne, Essen, Frankfurt Am Main, Freiburg im Breisgau, Guetersloh, Hamburg, Hamm, Herne, Hildesheim, Landshut, Ludwigsburg, Luedenscheid, Munich, Ostfildern, Ravensburg, Reutlingen, Rheine, Rostock, Ulm, Wermelskirchen
Age
18 years and over
People
267
Run by
Charite University, Berlin, Germany
See details and how to joinNCT07004413 · EU 2025-522377-12-00