Colorectal cancer trials in United Kingdom

In United Kingdom 89 Also abroad 1929

89 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Where
Cambridge, Cardiff, London, Manchester, Sutton
Age
18 years and over
People
542 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT04929223 · EU 2023-505163-37-00
Phase 1/2Taking people
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Where
Cardiff, Leeds, London, Manchester, Newcastle upon Tyne, Nottingham, Sutton
Age
18 years and over
People
910 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06324357
Phase 3Taking people
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Where
Aberdeen, Canterbury, Edinburgh, Liverpool, London, Manchester, Northwood
Age
18 years and over
People
900 worldwide
Run by
Summit Therapeutics
See details and how to joinNCT07228832
Phase 3Taking people
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Where
Aberdeen, London, Manchester
Age
18 years and over
People
1,020 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07549412 · EU 2025-524648-37-00
Phase 3Taking people
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Where
Birmingham, Cardiff, Coventry, London, Manchester, Oxford
Age
18 years and over
People
477 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06997497 · EU 2024-517232-22-00
Phase 3Taking people
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Where
Birmingham, Cambridge, Edinburgh, Hull, Leeds, London, Northwood, Sutton
Age
18 years and over
People
1,000 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06662786 · EU 2024-513852-13-00
Phase 3Taking people
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Where
Birmingham, Hull, Leeds, London, Northwood
Age
18 years and over
People
700 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06750094 · EU 2024-513853-66-00
Phase 1/2Taking people
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Where
Cambridge, London
Age
18 years and over
People
560 worldwide
Run by
Genmab
See details and how to joinNCT03526835 · EU 2024-513627-16-01
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Where
Bristol, Cardiff, Leeds, London, Maidstone, Manchester, Sutton
Age
18 years and over
People
700 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07284849 · EU 2025-523735-19-00
Phase 1/2Taking people
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Where
Coventry, London
Age
18 years and over
People
220 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06428409 · EU 2023-508703-21-00
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Cardiff, Dundonald, London, Sutton
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
Phase 1/2Taking people
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Where
Edinburgh, London, Manchester
Age
18 years and over
People
430 worldwide
Run by
Pfizer
See details and how to joinNCT04557449 · EU 2024-512120-11-00
Phase 1Taking people
A Study of MGC026 in Participants With Advanced Solid Tumors
Where
Oxford, Sutton
Age
18 years and over
People
394 worldwide
Run by
MacroGenics
See details and how to joinNCT06242470
Phase 2Taking people
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Where
Birmingham, London, Manchester, Oxford, Sutton
Age
18 years and over
People
390 worldwide
Run by
AbbVie
See details and how to joinNCT06820463 · EU 2024-512981-33-00
Phase 2Taking people
Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer
Where
Aberdeen, Cardiff, Glasgow, Leeds, London
Age
18 years and over
People
100 worldwide
Run by
Solstice Oncology, Inc.
See details and how to joinNCT07808151 · EU 2026-527233-58-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Birmingham, Cardiff, Dorchester, Glasgow, Guildford, London, Maidstone, Manchester, Metropolitan Borough of Wirral, Newcastle upon Tyne, Norwich, Oxford
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 1/2Taking people
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Where
Glasgow, London, Manchester
Age
18 years and over
People
542 worldwide
Run by
Artios Pharma Ltd
See details and how to joinNCT04657068
No phaseTaking people
Breath Research Narrow Validation for Gastrointestinal Cancer Detection
Where
Glasgow, Liverpool, London, Maidstone
Age
18 years and over
People
1,000
Run by
Imperial College London
See details and how to joinNCT07714538
Phase 1Taking people
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Where
London, Manchester, Sutton
Age
18 years and over
People
280 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT06004245 · EU 2023-503170-20-01
Phase 2Taking people
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Where
Coventry, London
Age
18 years and over
People
140 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT07811193 · EU 2026-525507-26-00
Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
Where
Southampton
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06607458
No phaseTaking people
Optimizing Patient Treatment With EPA-enriched Nutrition, a Randomised Control Trial
Where
Edinburgh, Gateshead, Liverpool
Age
18 years and over
People
118 worldwide
Run by
University of Edinburgh
See details and how to joinNCT07255066
Phase 1/2Taking people
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Where
Manchester
Age
18 years and over
People
346 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06885034
Phase 1/2Taking people
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Where
Leeds, London, Manchester, Newcastle upon Tyne, Sutton
Age
18 years and over
People
245 worldwide
Run by
BioNTech SE
See details and how to joinNCT07186842 · EU 2025-522613-26-00
Phase 1/2Taking people
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Where
London, Manchester
Age
18 years and over
People
554 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT05786924 · EU 2025-523474-16-00