Crohn's disease: open trials in United Kingdom

38 open trials have a site in United Kingdom. Registry data; only the trial team decides who can take part.

NCT07298421
A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · Hoffmann-La Roche
Birmingham Children's Hospital, Birmingham · King's College Hospital, London · Sheffield Childrens Hospital, Sheffield
Registry updated 2026-11-05
NCT05923073
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Royal Hospital for Sick Children, Glasgow · Great Ormond Street Hospital, London · Royal Manchester Children's Hospital, Manchester · Nowgen Centre, Research and Innovation, Manchester · John Radcliffe Hospital, Oxford · Sheffield Children's Hospital, Sheffield
Registry updated 2026-11-03
NCT06651281
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Whipps Cross University Hospital (Site 3400), London · MAC Research - Merseyside (Site 3401), Prescot
Registry updated 2026-11-03
NCT06663332
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Sheffield Children's Hospital, Sheffield · Royal Stoke University Hospital, Stoke-on-Trent · Haywood Hospital, Stoke-on-Trent
Registry updated 2026-11-03
NCT07196722
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 2/3 · Janssen Research & Development, LLC
Queen Elizabeth Hospital Birmingham, Birmingham · Addenbrooke's Hospital, Cambridge · Glasgow Royal Infirmary, Glasgow · Fairfield General Hospital, Greater Manchester · Guy's Hospital, London · St Georges University Hospital NHS Foundation Trust, London · Whipps Cross University Hospital, London · Whiston Hospital, Rainhill · Stepping Hill Hospital, Stockport
Registry updated 2026-11-03
NCT07242248
A Study to Observe Real-world Evidence of Guselkumab Treatment in Participants With Ulcerative Colitis and Crohn's Disease in the United Kingdom (UK)
Research · Janssen-Cilag Ltd.
London North West University Healthcare NHS Trust, Harrow
Registry updated 2026-11-03
NCT07363044
A Prospective Randomised Study of Treatment Selection Based on Epigenetic Markers Versus Standard of Care Treatment Selection in Adults With CROHN's Disease
Trial Treatment · Alimentiv Inc.
Northern Care Alliance - Fairfield General Hospital, Bury · Cambridge University Hospitals NHS Trust, Cambridge · Hull University Teaching Hospital NHS Trust, Cottingham · The Dudley Group Nhs Foundation Trust, Dudley · Cardiff & Vale UHB, Llandough · Barts Health NHS Trust, London · King's College Hospital NHS Foundation Trust, London · Guy's and St Thomas' NHS Foundation Trust, London · Oxford University Hospitals NHS Foundation Trust, Oxford · University Hospital Southampton NHS Foundation Trust, Southampton · Hampshire Hospital NHS Foundation Trust, Winchester
Registry updated 2026-11-03
NCT07499232
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Barts Health NHS Trust, Greater London · London North West University Healthcare NHS Trust, Greater London · West Middlesex University Hospital, Iselworth · Imperial College London, London · University College London Hospitals NHS Foundation Trust, London · Chelsea And Westminster Hospital, London · Royal Free Hospital, London · Norfolk and Norwich University Hospital, Norwich · New Cross Hospital, Wolverhampton
Registry updated 2026-11-03
NCT07577843
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
University Hospitals Birmingham NHS Foundation Trust, Birmingham · Fairfield General Hospital, Bury · Cardiff and Vale UHB - University Hospital of Wales, Cardiff · Ninewells Hospital, Dundee · Ulster Hospital, Dundonald · Royal Devon & Exeter Hospital, Exeter · Glasgow Royal Infirmary, Glasgow · Kings College Hospital, London · St Georges Healthcare NHS Trust, London · Chelsea And Westminster Hospital, London · Royal Victoria Infirmary, Newcastle upon Tyne · Oxford University Hospitals NHS Foundation Trust, Oxford
Registry updated 2026-11-03
NCT06233461
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 2 · Takeda
South Eastern Health and Social Care Trust - The Ulster Hospital, Belfast · Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge · St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust, London · NIHR UCLH Clinical Research Facility - University College London Hospitals NHS Foundation Trust, London · Wingate Institute for Neurogastroenterology, Wingate Clinical Trials Facility, Barts Health NHS Trust, London
Registry updated 2026-11-02
NCT06430801
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Southmead Hospital (Site 2403), Bristol · Addenbrooke's Hospital (Site 2400), Cambridge · Doncaster Royal Infirmary (Site 2401), Doncaster · Royal Devon & Exeter Hospital ... (Site 2407), Exeter · Huddersfield Royal Infirmary (Site 2409), Huddersfield · Whipps Cross University Hospital-Clinical Research Unit (Site 2404), London · University College London Hospital-Clinical Research Facility (Site 2405), London · The John Radcliffe Hospital (Site 2406), Oxford · Southampton General Hospital (Site 2402), Southampton · Walsall Manor Hospital (Site 2410), West Midlands
Registry updated 2026-11-02
NCT06958536
A Study to Investigate Efficacy and Safety of Brivekimig in Participants With Crohn's Disease
Trial Treatment · Phase 2 · Sanofi
Bury · Cambridge · Dagenham · London · London · London
Registry updated 2026-11-02
NCT07683325
NOV-ERA - A Clinical Trial to Assess the Efficacy and Safety of Ontunisertib Compared to Placebo in Patients With Fibrostenosing Crohn's Disease
Trial Treatment · Phase 2 · Agomab Spain S.L.U.
Royal London Hospital, London
Registry updated 2026-10-29
NCT06579443
Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study
Research · University Hospitals Coventry and Warwickshire NHS Trust
University Hospitals Coventry & Warwickshire (UHCW) NHS Trust, Coventry · London North West University Healthcare NHS Trust, Harrow · Guy's and St Thomas' NHS Foundation Trust, London · Chelsea and Westminster Hospital NHS Foundation, London · Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne · Oxford University Hospitals NHS Foundation Trust, Oxford
Registry updated 2026-10-27
NCT06819891
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · Hoffmann-La Roche
Southmead Hospital, Bristol · Fairfield General Hospital, Bury · Bronglais General Hospital, Llanrhystud · Royal London Hospital, London · Royal Victoria Infirmary, Newcastle upon Tyne · Stepping Hill Hospital, Stockport
Registry updated 2026-10-26
NCT07184931
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · Sanofi
Cambridge · Cottingham · London · London · Norwich · Rochdale
Registry updated 2026-10-21
NCT05995353
A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · AbbVie
Birmingham Women's and Children's NHS Foundation Trust /ID# 255759, Birmingham · Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 255757, London · Sheffield Children's Hospital NHS Foundation Trust /ID# 255758, Sheffield
Registry updated 2026-10-20
NCT06819878
A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease
Trial Treatment · Phase 3 · Hoffmann-La Roche
Addenbrookes Hospital, Cambridge · St Mark's Hospital & Imperial College, Harrow · Royal Liverpool University Hospital, Liverpool · Queen Anne Street Medical Centre, London · King College Hospital NHS Foundation Trust, London · Royal Victoria Infirmary, Newcastle upon Tyne · North Tyneside General Hospital, North Shields · Nottingham University Hospitals Queen's Medical Centre, Nottingham
Registry updated 2026-10-16
NCT04844606
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
Trial Treatment · Phase 3 · Eli Lilly and Company
Royal London Hospital, London · The John Radcliffe Hospital, Oxford · Sheffield Children's Hospital, Sheffield
Registry updated 2026-10-07
NCT05509777
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
Trial Treatment · Phase 3 · Eli Lilly and Company
Royal Hospital for Children and Young People, Edinburgh · Oxford University Hospitals NHS trust John Radcliffe hospital, Headington · Great Ormond Street Hospital For Children NHS Foundation Trust, London · Manchester University NHS Foundation Trust, Manchester · Sheffield Children's Hospital, Sheffield · Royal London Hospital, Whitechapel
Registry updated 2026-10-07
NCT06548542
Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Trial Treatment · Phase 2 · AbbVie
Velocity Clinical Research - Bristol /ID# 275736, Bristol · University Hospital of Wales /ID# 275702, Cardiff · University Hospital Coventry & Warwickshire NHS Trust /ID# 267128, Coventry · Western General Hospital /ID# 266333, Edinburgh · Gartnavel General Hospital /ID# 266407, Glasgow · St George University Hospitals NHS Foundation Trust /ID# 266335, London · Barts Health NHS Trust /ID# 266410, London · Guy's and St Thomas' NHS Foundation Trust /ID# 266336, London · Royal Free Hospital /ID# 268065, London · Royal Victoria Infirmary /ID# 268064, Newcastle upon Tyne · The John Radcliffe Hospital /ID# 266334, Oxford · The Royal Wolverhampton NHS Trust /ID# 268158, Wolverhampton
Registry updated 2026-09-25
NCT07152431
Fibrosis Associated Protein Inhibitor (FAPI) Radiotracer-based Imaging to Identify Fibrotic Intestinal Crohn's Disease
Research · University of Edinburgh
NHS Lothian, Edinburgh
Registry updated 2026-09-18
NCT07403968
A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease
Trial Treatment · Phase 2 · Takeda
Oxford Experimental Medicine Clinical Research Facility, Oxford
Registry updated 2026-08-24
NCT03571373
PIBD-SETQuality: the Inception Cohort and Safety Registry
Research · Erasmus Medical Center
Royal Hospital London, London
Registry updated 2026-08-11
NCT06956703
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
Research · University of Nottingham
University of Nottingham, Nottingham
Registry updated 2026-07-08

All Crohn's disease trials and the map

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