Depression: open trials in Canada

65 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT07775300
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Trial Treatment · Phase 3 · Eli Lilly and Company
CaRe Clinic, Calgary · Kelowna Health and Memory Centre, Kelowna · Providence Care, Kingston · Alpha Recherche Clinique - Lévis, Lévis · AMNDX, Markham · Malton Medical Group, Mississauga · Alpha Recherche Clinique, Québec · Richmond Clinical Trials, Richmond · Research, Innovation, Science and Excellence (RISE) Institute, Toronto
Registry updated 2026-11-03
NCT06966401
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 3 · Neurocrine Biosciences
Neurocrine Clinical Site, North Vancouver · Neurocrine Clinical Site, Toronto
Registry updated 2026-11-02
NCT07906496
Acceptance and Committment Therapy Combined With Ketamine in Difficult-to-Treat Depression.
Trial Treatment · University of British Columbia
UBC Hospital, Vancouver
Registry updated 2026-10-30
NCT07376018
Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
Trial Treatment · Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-10-28
NCT07405606
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder
Trial Treatment · Phase 2 · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health, Toronto
Registry updated 2026-10-26
NCT06781697
InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression
Trial Treatment · Phase 3 · Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-10-23
NCT06854367
Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
Trial Treatment · Centre for Addiction and Mental Health
Centre for Addiction and Mental Healh, Toronto · Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-10-22
NCT06518720
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Trial Treatment · Phase 2 · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health, Toronto
Registry updated 2026-10-21
NCT06512220
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)
Trial Treatment · Phase 2 · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health, Toronto
Registry updated 2026-10-19
NCT07810738
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
Trial Treatment · Phase 2 · Washington University School of Medicine
Center for addiction and Mental Health (CAMH), Toronto
Registry updated 2026-10-16
NCT07412756
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Trial Treatment · Phase 3 · Eli Lilly and Company
Heritage Medical Research Clinic, Calgary · Hamilton Medical Research Group, Hamilton · Kelowna Health and Memory Centre, Kelowna · Alpha Recherche Clinique - Lévis, Lévis · Genge Partners, Montreal · Dar Clinical Research - Ottawa, Ottawa · Centre de Recherche Saint-Louis inc., Québec · Alpha Recherche Clinique, Québec · Richmond Clinical Trials, Richmond · Bluewater Clinical Research Group Inc., Sarnia · Diex Recherche Sherbrooke, Sherbrooke · Centre for Neurology Studies, Surrey · Maple Leaf Research, Toronto
Registry updated 2026-10-05
NCT06528938
Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
Trial Treatment · The Royal Ottawa Mental Health Centre
The Royal's Institute of Mental Health Research, Ottawa
Registry updated 2026-10-01
NCT06773949
Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression
Trial Treatment · The Royal Ottawa Mental Health Centre
Royal Ottawa Mental Health Centre, Ottawa
Registry updated 2026-09-29
NCT07682207
Accelerated iTBS for PTSD and Depression
Trial Treatment · Lawson Research Institute of St. Joseph's
St. Joseph's Health Care London, Parkwood Institute Mental Health Care Building, London
Registry updated 2026-09-18
NCT03537794
Characterizing Synaptic Density in Treatment Resistant Depression
Research · Unity Health Toronto
Unity Health Toronto, Toronto
Registry updated 2026-09-15
NCT06943573
Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder
Trial Treatment · Phase 2 · Lakshmi N Yatham
Department of Psychiatry, University of Ottawa, The Ottawa Hospital, Ottawa · Department of Psychiatry, University of Toronto, University Health Network,, Toronto · Djavad Mowafaghian Centre for Brain Health, Vancouver
Registry updated 2026-09-15
NCT07801703
Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression
Trial Treatment · Phase 2/3 · The Royal's Institute of Mental Health Research
The Royal, Ottawa
Registry updated 2026-09-03
NCT04569448
Brexpiprazole Treatment for Bipolar I Depression
Trial Treatment · Phase 3 · Douglas Mental Health University Institute
McMaster University, Hamilton · Jewish General Hospital, Montreal · Douglas Mental Health University Institute, Montreal
Registry updated 2026-08-27
NCT07783633
Identifying Biomarkers of Response to Digital Interventions for Mood Disorders
Trial Treatment · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health (CAMH), Toronto
Registry updated 2026-08-27
NCT04999553
Left vs. Right Non-Inferiority Trial
Trial Treatment · University of British Columbia
Centre for Addiction and Mental Health, Toronto · Non-Invasive Neurostimulation Therapies Centre, University of British Columbia, Vancouver
Registry updated 2026-08-25
NCT07211438
Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression
Trial Treatment · Phase 2 · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health, Toronto · Toronto Western Hospital, University Health Network, Toronto
Registry updated 2026-08-21
NCT05142683
Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial
Trial Treatment · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health, Toronto
Registry updated 2026-08-20
NCT05097586
RCT of At-Home tDCS for Depression in Pregnancy
Trial Treatment · Women's College Hospital
Women's College Hospital, Toronto · Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-08-10
NCT06963021
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 3 · Neurocrine Biosciences
Neurocrine Clinical Site, Toronto · Neurocrine Clinical Site, Verdun
Registry updated 2026-08-10
NCT07749521
Optimizing Treatment for Depressed Parents of Children With Emotional and Behavioural Problems
Trial Treatment · University of Toronto
Ontario Institute for Studies in Education (OISE), Toronto
Registry updated 2026-08-06

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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