Depression: open trials in Canada

65 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT07737990
Psilocybin-Assisted Group Integration Psychotherapy for Treatment-Resistant Depression
Trial Treatment · Joshua Rosenblat
Toronto Western Hospital, Toronto
Registry updated 2026-07-30
NCT07569198
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
Trial Treatment · Phase 2 · Joshua Rosenblat
Toronto Western Hospital, Toronto
Registry updated 2026-07-29
NCT07250893
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
Trial Treatment · St. Joseph's Healthcare Hamilton
St. Joseph's Healthcare Hamilton, Hamilton
Registry updated 2026-07-14
NCT06746155
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Research · Abraham Nunes
University Of Calgary, Calgary · Nova Scotia Health, Halifax · McMaster University, Hamilton · Queen's University, Kingston · The Royal Ottawa Mental Health Centre, Ottawa · University Health Network, Toronto · Centre for Addiction and Mental Health (CAMH), Toronto · University of British Columbia, Vancouver · Ontario Shores Centre for Mental Health Sciences, Whitby
Registry updated 2026-07-10
NCT05017311
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
Trial Treatment · Phase 4 · Nova Scotia Health Authority
University Of Calgary, Calgary · Nova Scotia Health Authority, Halifax · McMaster University, Hamilton · Queen's University, Kingston · The Royal Ottawa Mental Health Centre, Ottawa · University of Saskatchewan, Saskatoon · Centre for Addiction and Mental Health, Toronto · University Health Network, Toronto · University of British Columbia, Vancouver · Ontario Shores Centre for Mental Health Sciences, Whitby
Registry updated 2026-06-11
NCT07620288
Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging
Trial Treatment · The Royal Ottawa Mental Health Centre
The Royal's Institute of Mental Health Research, Ottawa
Registry updated 2026-06-09
NCT03953014
Pharmacogenetics of Antidepressant-Induced Disinhibition
Research · University of Calgary
Child and Adolescent Addiction, Mental Health & Psychiatry, Calgary
Registry updated 2026-05-14
NCT06972368
Home-Based tDCS for Depression in BPD
Trial Treatment · Ciusss de L'Est de l'Île de Montréal
IUSMM, Montreal
Registry updated 2026-05-06
NCT07562074
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
Trial Treatment · Phase 1 · University of Calgary
Foothills Medical Centre, Calgary
Registry updated 2026-05-01
NCT07373535
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy
Trial Treatment · Phase 2 · Kyle Greenway
Jewish General Hospital, Montreal
Registry updated 2026-04-22
NCT06072898
A Randomized Neuroimaging Trial of Psilocybin in Depression
Trial Treatment · Phase 2 · Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre, Toronto
Registry updated 2026-03-30
NCT04159662
Brain Imaging of Cognition Inn Schizophrenia and Depression
Research · The Royal Ottawa Mental Health Centre
Royal Ottawa Mental Health Center, Ottawa
Registry updated 2026-03-23
NCT04972136
rTMS for Depression in Young Adults With Autism
Trial Treatment · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health, Toronto
Registry updated 2026-03-19
NCT06620276
ACT_for Alcohol Use Disorder and Depression
Trial Treatment · Centre hospitalier de l'Université de Montréal (CHUM)
Centre Hospitalier de l'Université de Montréal, Montreal
Registry updated 2026-03-05
NCT06856161
A Novel Blood Test as a Biomarker in Mental Health
Research · Fraser Health
Royal Columbian Hospital, New Westminster
Registry updated 2026-03-05
NCT07091643
Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT)
Trial Treatment · Baycrest
Baycrest Hospital, Toronto
Registry updated 2026-02-27
NCT07262008
Sustained Mood Improvement With Laughing Gas Exposure
Trial Treatment · Phase 3 · Women's College Hospital
Toronto Western Hospital (UHN), Toronto · St. Michael's Hospital (Unity Health), Toronto · Sunnybrook Health Sciences Centre, Toronto · Toronto General Hospital, UHN, Toronto · Women's College Hospital, Toronto
Registry updated 2025-12-10
NCT07212465
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
Trial Treatment · Rotman Research Institute at Baycrest
Rotman Research Institute at Baycrest, Toronto
Registry updated 2025-10-28
NCT03665831
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
Trial Treatment · Rotman Research Institute at Baycrest
Rotman Research Institute at Baycrest, Toronto
Registry updated 2025-10-27
NCT06763081
Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation
Research · University of Manitoba
Shared Health Facilities, Winnipeg · University of Manitoba College of Pharmacy, Winnipeg
Registry updated 2025-09-08
NCT06619366
The Impact of Coach-guided Risk Communication on the Risk of Major Depression
Trial Treatment · Dalhousie University
Faculty of Medicine, Halifax
Registry updated 2025-09-02
NCT07140575
rTMS for Youth Inpatients With Depression
Trial Treatment · Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre, Toronto
Registry updated 2025-08-24
NCT07094789
Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
Trial Treatment · Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre, Toronto
Registry updated 2025-08-11
NCT07108257
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
Trial Treatment · Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre, Toronto
Registry updated 2025-08-06
NCT07033780
Theta-Burst Stimulation to Treat Depression
Trial Treatment · Phase 1 · Centre for Addiction and Mental Health
Centre for Addiction and Mental Health, Toronto
Registry updated 2025-06-24

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error