Depression trials in Canada

In Canada 75 Also abroad 685

65 of 75 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Integrated Suicide & Trauma Therapy for Suicide Risk
Where
Toronto
Age
18 years and over
People
20
Run by
Unity Health Toronto
See details and how to joinNCT05613972
No phaseTaking people
RCT of At-Home tDCS for Depression in Pregnancy
Where
Toronto
Age
18 years and over
People
156
Run by
Women's College Hospital
See details and how to joinNCT05097586
Phase 3Taking people
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Toronto, Verdun
Age
18 years and over
People
200 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06963021 · EU 2024-519421-37-00
No phaseEnrolling by invitation
Psilocybin-Assisted Group Integration Psychotherapy for Treatment-Resistant Depression
Where
Toronto
Age
18 years and over
People
65
Run by
Joshua Rosenblat
See details and how to joinNCT07737990
Phase 2Taking people
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
Where
Toronto
Age
18 years to 70 years
People
120
Run by
Joshua Rosenblat
See details and how to joinNCT07569198
No phaseTaking people
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
Where
Hamilton
Age
18 years to 65 years
People
50
Run by
St. Joseph's Healthcare Hamilton
See details and how to joinNCT07250893
Phase 4Taking people
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
Where
Calgary, Halifax, Hamilton, Kingston, Ottawa, Saskatoon, Toronto, Vancouver, Whitby
Age
18 years to 65 years
People
400
Run by
Nova Scotia Health Authority
See details and how to joinNCT05017311
No phaseNot yet taking people in Canada
Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging
Where
Ottawa
Age
18 years to 55 years
People
20
Run by
The Royal Ottawa Mental Health Centre
See details and how to joinNCT07620288
No phaseTaking people
Home-Based tDCS for Depression in BPD
Where
Montreal
Age
18 years to 65 years
People
60
Run by
Ciusss de L'Est de l'Île de Montréal
See details and how to joinNCT06972368
Phase 1Not yet taking people in Canada
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
Where
Calgary
Age
18 years to 65 years
People
20
Run by
University of Calgary
See details and how to joinNCT07562074
Phase 2Not yet taking people in Canada
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy
Where
Montreal
Age
21 years and over
People
16
Run by
Kyle Greenway
See details and how to joinNCT07373535
Phase 2Taking people
Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
Where
Toronto
Age
18 years to 65 years
People
30
Run by
Roger McIntyre
See details and how to joinNCT07523048
Phase 2Taking people
A Randomized Neuroimaging Trial of Psilocybin in Depression
Where
Toronto
Age
18 years to 64 years
People
50
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT06072898
No phaseTaking people
rTMS for Depression in Young Adults With Autism
Where
Toronto
Age
16 years to 35 years
People
80
Run by
Centre for Addiction and Mental Health
See details and how to joinNCT04972136
No phaseTaking people
ACT_for Alcohol Use Disorder and Depression
Where
Montreal
Age
18 years to 70 years
People
30
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT06620276
No phaseNot yet taking people in Canada
Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT)
Where
Toronto
Age
40 years to 60 years
People
30
Run by
Baycrest
See details and how to joinNCT07091643
Phase 3Not yet taking people in Canada
Sustained Mood Improvement With Laughing Gas Exposure
Where
Toronto
Age
18 years to 65 years
People
120
Run by
Women's College Hospital
See details and how to joinNCT07262008
No phaseTaking people
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
Where
Toronto
Age
60 years to 85 years
People
24
Run by
Rotman Research Institute at Baycrest
See details and how to joinNCT07212465
No phaseTaking people
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
Where
Toronto
Age
60 years and over
People
28
Run by
Rotman Research Institute at Baycrest
See details and how to joinNCT03665831
No phaseTaking people
The Impact of Coach-guided Risk Communication on the Risk of Major Depression
Where
Halifax
Age
18 years to 65 years
People
1,000
Run by
Dalhousie University
See details and how to joinNCT06619366
No phaseTaking people
rTMS for Youth Inpatients With Depression
Where
Toronto
Age
14 years to 19 years
People
30
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT07140575
Phase 1Taking people
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for Refractory Anorexia Nervosa With Comorbid Obsessive Compulsive Disorder or Major Depressive Disorder
Where
Toronto
Age
18 years to 65 years
People
10
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT07113665
No phaseTaking people
Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
Where
Toronto
Age
18 years to 65 years
People
20
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT07094789
No phaseTaking people
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
Where
Toronto
Age
18 years to 65 years
People
10
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT07108257
Phase 1Taking people
Theta-Burst Stimulation to Treat Depression
Where
Toronto
Age
18 years to 50 years
People
84
Run by
Centre for Addiction and Mental Health
See details and how to joinNCT07033780