Depression: open trials in Italy

19 open trials have a site in Italy. Registry data; only the trial team decides who can take part.

NCT06559306
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia · Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania, Catania · Azienda Sanitaria Locale 2 Lanciano Vasto Chieti, Chieti · IRCCS Ospedale Policlinico San Martino, Genoa · Fondazione IRCCS San Gerardo dei Tintori, Monza · Azienda Ospedaliera di Padova, Padova · Azienda Ospedaliero Universitaria Pisana, Pisa · Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome · Azienda Ospedaliero-Universitaria Sant Andre, Rome · Azienda Sanitaria Locale Di Salerno, Salerno · Azienda Ospedaliera Universitaria Senese, Siena
Registry updated 2026-11-03
NCT06966401
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Trial Treatment · Phase 3 · Neurocrine Biosciences
Ospedale San Raffaele S.r.l., Milan · Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome · Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino, Turin
Registry updated 2026-11-02
NCT06990035
Implementation of a Multiple Intervention to Promote Healthy Lifestyles in Patients With Depression
Trial Treatment · IRCCS Centro San Giovanni di Dio Fatebenefratelli
IRCCS Centro San Giovanni fi Dio Fatebenefratelli, Brescia · Comunità Fraternità società cooperativa sociale ONLUS, Ospitaletto
Registry updated 2026-10-27
2025-523346-27-00
Trazodone’s Effects on Moderation of Psilocybin Outcomes (TEMPO)
Trial Treatment · Phase 2 · Universita' Degli Studi G. D'Annunzio Di Chieti
Universita' Degli Studi G. D'Annunzio Di Chieti, Chieti Scalo
Registry updated 2026-08-14
2024-513022-29-00
A study to evaluate Samyr effectiveness and safety profile. The study is done by comparing that Samyr injection is better than placebo injection in subjects with depression which are treated regularly with antidepressant tablet treatment.
Trial Treatment · Phase 3 · Mylan Inc.
Dipartimento Salute Mentale c/o P.O.Maria SS. dello Splendore, Giulianova · Azienda Ospedaliera di Padova, Padova · Azienda Ospedaliero Universitaria Pisana, Pisa
Registry updated 2026-08-06
2024-513019-29-00
A research study to compare the antidepressant ability and safety of Samyr® tablets versus placebo tablets as an adjunct to additional antidepressant treatment in patients with major depressive disorder (MDD)
Trial Treatment · Phase 3 · Mylan Inc.
Casa di Cura Villa San Benedetto Menni, Suore Ospedaliere, Albese con Cassano - Como · Azienda Ospedaliero-Universitaria Ss.Antonio E Biagio E C.Arrigo Alessandria, Alexandria · Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo · Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania, Catania · Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan · ASST Fatebenefratelli Sacco, Milan · Ospedale San Raffaele S.r.l., Milan · Fondazione IRCCS San Gerardo dei Tintori, Monza · Azienda Socio-Sanitaria Territoriale di Pavia, Pavia · Fondazione Santa Lucia, Rome · Azienda Ospedaliero-Universitaria Sant Andre, Rome · Azienda Sanitaria Locale Di Salerno, Salerno
Registry updated 2026-07-29
NCT07649993
Non-Coding RNAs Gene Expression in Psychiatric Disorders
Research · Carmen Concerto
Psychiatry Unit, Via Santa Sofia 78, Catania · Psychiatry Unit, Contrada Ferrante SNC, Enna · Cellular and Molecular Biology Laboratory, Tower of Biological Laboratories, 5th Floor Via Consolare Valeria 1, Messina · Psychiatry Unit, Via Consolare Valeria 1, Messina · Psychiatry Unit, Via del Vespro 129, Palermo
Registry updated 2026-06-23
NCT07088380
Ketamine Augmentation of ECT in Treatment-Resistant Depression
Trial Treatment · Phase 3 · Università Vita-Salute San Raffaele
IRCCS Ospedale San Raffaele Turro, Milan
Registry updated 2026-05-11
NCT07146503
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
Research · Riccardo Guglielmo
Università di Chieti, Chieti · Csm Dds 8, Genova · Ospedale Policlinico San Martino, Genova · ASST Fatebenefratelli Sacco, Milan · ASST Pavia, Pavia
Registry updated 2026-03-31
2024-512559-20-01
The additive effect of ketamine in combination with electroconvulsive stimulation (ECS) in major depressive disorder (MDD): a translational study
Trial Treatment · Phase 3 · Universita' Vita-salute S. Raffaele
Ospedale San Raffaele S.r.l., Milan
Registry updated 2026-03-02
NCT07009223
Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice
Trial Treatment · IRCCS Centro San Giovanni di Dio Fatebenefratelli
IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia
Registry updated 2026-02-11
NCT06207760
Effect of Minocycline on Inflammation in Depressed Patients
Trial Treatment · Phase 2 · Provincia Lombardo Veneta Dell’Ordine Ospedaliero Di San Giovanni Di Dio Fatebenefratelli
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia · Provincia Lombardo Veneta Dell’Ordine Ospedaliero Di San Giovanni Di Dio Fatebenefratelli, Brescia
Registry updated 2026-02-04
NCT04975724
A randomized, double-blind, placebo-controlled, multicenter clinical trial to assess safety and effectiveness of Liposom in enhance and speed up response to antidepressant therapy with citalopram in elderly patients suffering from Major Depressive Disorder (MDD)
Trial Treatment · Phase 4 · Fidia Farmaceutici S.p.A.
PO San Filippo e Nicola di Avezzano - ASL1 Avezzano Sulmona L'Aquila, Avezzano · ASST Fatebenefratelli Sacco, Milan · Azienda Ospedaliero-Universitaria Sant Andre, Rome
Registry updated 2025-12-23
2024-519844-34-03
Psilocybin versus Personalized Neuromodulation for Resistant Depression (PSILO-MODULATION)
Trial Treatment · Phase 2 · Universita' Degli Studi G. D'Annunzio Di Chieti
Universita' Degli Studi G. D'Annunzio Di Chieti, Chieti Scalo · ASL Roma 5, Colleferro (RM) · Azienda Ospedaliero Universitaria - Policlinico Riuniti Foggia, Foggia
Registry updated 2025-11-19
NCT05973786
The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Trial Treatment · Phase 3 · Dr. Inge Winter
University of Brescia, Brescia · Clinica Psichiatrica, 1st floor, Cagliari · Universita degli Studi della Campania Luigi Vanvitelli, Naples · Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino, Turin
Registry updated 2025-09-26
NCT05973851
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Trial Treatment · Phase 3 · Dr. Inge Winter
University of Brescia, Brescia · Clinica Psichiatrica, 1st floor, Cagliari · Universita degli Studi della Campania Luigi Vanvitelli, Naples · Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino, Turin
Registry updated 2025-09-26
2025-520899-25-00
PILOT STUDY ON THE EFFECTIVENESS OF CHOLINE ALFOSCERATE IN THE UNDER THRESHOLD DEPRESSION OF THE ELDERLY
Trial Treatment · Phase 4 · Azienda Socio Sanitaria Territoriale Di Lodi
Azienda Socio Sanitaria Territoriale di Lodi, Lodi
Registry updated 2025-08-22
2023-508303-20-01
Evaluation of p-glycoprotein alterations in treatment-resistant depression: a [18F]MC225 PET study
Trial Treatment · Phase 2 · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome
Registry updated 2025-04-16
NCT05798143
Translational Biomarkers in Accelerated Neuromodulation for Treatment-resistant Depression
Trial Treatment · ITAB - Institute for Advanced Biomedical Technologies
ITAB, Chieti
Registry updated 2023-04-04

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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