Depression: open trials in United States

• NCT07065240

  A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

  Trial Treatment · Phase 2 · Seaport Therapeutics

  Allentown · Atlanta · Boston · Brooklyn · Cedarhurst · Chino · Cromwell · Dallas · Decatur · Everett · Garden Grove · Glendale · Independence · Irving · Jacksonville · Lauderhill · Marietta · New York · North Canton · Orlando · Palm Bay · Redlands · Richardson · Russells Mills · San Jose · Staten Island · St Louis · West Palm Beach

  Registry updated 2026-10-06

• NCT07161700

  An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study)

  Trial Treatment · Phase 2 · Seaport Therapeutics

  Atlanta · Boston · Brooklyn · Cedarhurst · Chino · Cromwell · Decatur · Garden Grove · Glendale · Independence · Irving · Lauderhill · New York · North Canton · Palm Bay · Richardson · San Jose · Staten Island · St Louis · West Palm Beach

  Registry updated 2026-10-06

• NCT07369557

  Mindfulness Training During Accelerated TMS for Depression

  Trial Treatment · Medical University of South Carolina

  Medical University of South Carolina (MUSC), Brain Stimulation Laboratory Institute of Psychiatry, Charleston · IOP, Charleston

  Registry updated 2026-10-06

• NCT06511908

  Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

  Trial Treatment · Phase 2 · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-05

• NCT04877977

  Long-term Observation of Participants With Mood Disorders

  Research · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-01

• NCT05703685

  [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

  Trial Treatment · Phase 1 · National Institute of Mental Health (NIMH)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-01

• NCT06835855

  Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression

  Trial Treatment · Binghamton University

  Binghamton University, Binghamton

  Registry updated 2026-09-30

• NCT05703412

  Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness

  Trial Treatment · Butler Hospital

  Butler Hospital, Providence

  Registry updated 2026-09-29

• NCT07845604

  Precision Depression Adalimumab Trial

  Trial Treatment · Phase 2 · Daniel Moriarity

  University of Pennsylvania, Philadelphia

  Registry updated 2026-09-29

• NCT07003997

  JAK Signaling in Depression

  Trial Treatment · Phase 2 · Emory University

  Emory University, Atlanta

  Registry updated 2026-09-28

• NCT06605105

  Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)

  Trial Treatment · Phase 3 · Cybin IRL Limited

  Cenexel iResearcvh Atlanta, LLC, Atlanta · Atlanta Center for Medical Research, Atlanta · Adams Clinical Boston, Boston · Neurobehavioral Clinical Research, Canton · Uptown Research Institute, Chicago · Mountain View Clinical Research, Denver · Adams Clinical Dallas, DeSoto · Cedar Clinical Research, Draper · Institute for Integrative Therapies, Eden Prairie · Starlight Clinical Research, Evergreen · Behavioral Research Specialists, LLC, Glendale · Research Centers of America, Hollywood · Zillan Clinical Research, Houston · Clinical Neuroscience Solutions, Jacksonville · K2 Medical Research, Lady Lake · Kadima Neuropsychiatry Institute, La Jolla · Redbird Research, Las Vegas · Segal Trials Center for Psychedelic Research, Lauderhill · TRIP Clinic and Psychedelic Science Institute, Los Angeles · CalNeuro Research Group, Los Angeles · Lipov Medical Group, Los Angeles · K2 Medical Research, Maitland · Accel Research Sites - Maitland, Maitland · Clinical Neuroscience Solutions, CNS Healthcare, Memphis · Adams Clinical Harlem, New York · Excell Research, Inc., Oceanside · Charter Research, Orlando · Clinical Neuroscience Solutions, Inc., Orlando · Combined Research Orlando Phase I-IV, Orlando · Adams Clinical Philadelphia, Philadelphia · Scottsdale Research Institute, Phoenix · Global Medical Institutes Princeton Medical Institute, Princeton · Sunstone Medical, PC, Rockville · Open Mind Collective / UCSF Medical Center - Mount Zion, San Francisco · Inland Psychiatric Medical Group Inc (IPMG Research), San Juan Capistrano · CenExel iResearch, Savannah · Psychiatric Medicine Associates, LLC, Skokie · Psychiatric Medicine Associates, Skokie · Elixia Health, Springfield · Adams Clinical Bronx, The Bronx · Bio Behavioral Health, Toms River · Adams Clinical, Watertown

  Registry updated 2026-09-25

• NCT07657234

  tDCS for Late-Life Depression

  Trial Treatment · Phase 1/2 · Andre Russowsky Brunoni

  University of Texas Southwestern Medical Center, Dallas

  Registry updated 2026-09-25

• NCT07842601

  Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation

  Trial Treatment · University of Kentucky

  University of Kentucky, Lexington

  Registry updated 2026-09-25

• NCT06572683

  Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder

  Trial Treatment · University of California, Los Angeles

  University of California, Los Angeles

  Registry updated 2026-09-24

• NCT06830044

  Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

  Trial Treatment · Phase 3 · Vanda Pharmaceuticals

  Bellevue · Boston · Carmel · Charlotte · Chicago · Cincinnati · Colorado Springs · Fort Myers · Garden Grove · Houston · Las Vegas · Little Rock · Media · Miami · New York · Orange · Phoenix · Plano · Redlands · Richardson · Saint Charles · San Jose · Snellville · Staten Island · Tampa · Walnut Creek · Witchita Falls

  Registry updated 2026-09-24

• NCT07247006

  Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression

  Trial Treatment · Phase 2 · University of Rochester

  University of Rochester Medical Center, Rochester

  Registry updated 2026-09-24

• NCT07639606

  Mobile Cognitive Behavioral Therapy in Early Stroke Recovery

  Trial Treatment · Weill Medical College of Cornell University

  Weill Cornell Medicine, New York

  Registry updated 2026-09-23

• NCT05773755

  DBS for TRD With the Medtronic Percept PC

  Trial Treatment · Helen Mayberg, MD

  Icahn School of Medicine at Mount Sinai/Mount Sinai West, New York

  Registry updated 2026-09-22

• NCT07779707

  The Medically Tailored Groceries and Mental Health Study

  Trial Treatment · University of Massachusetts, Worcester

  UMASS Memorial Health, Worcester · UMass Chan Medical School, Worcester · Community Care Cooperative (C3), Worcester

  Registry updated 2026-09-22

• NCT07834684

  Singula Phase 0.1 Primary Care Pilot

  Research · Singula Health, Inc.

  Morris Medical Office, Brentwood · WestDocs Concierge, Mount Kisco

  Registry updated 2026-09-22

• NCT07834762

  Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression

  Trial Treatment · University of California, San Diego

  UCSD Interventional Psychiatry, San Diego

  Registry updated 2026-09-22

• NCT06968390

  Accelerated TMS for Perinatal Depression

  Trial Treatment · Brigham and Women's Hospital

  Brigham and Women's Hospital, Boston

  Registry updated 2026-09-18

• NCT07105111

  A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

  Trial Treatment · Phase 4 · Neurocrine Biosciences

  Augusta · Austin · Bonita Springs · Bryant · Chino · Fresno · Hialeah · Independence · Long Beach · Miami · Naperville · Omaha · Orange · Orange City · Port Charlotte · Redlands · Richmond · San Diego · Tampa

  Registry updated 2026-09-18

• NCT07824206

  Lumateperone Added to Antidepressant Therapy in Adults With Major Depressive Disorder Experiencing Emotional Blunting

  Trial Treatment · Phase 4 · Future Options Research, LLC

  Future Options Research, State College

  Registry updated 2026-09-17

• NCT07623135

  Lumateperone for Late-Life Depression

  Trial Treatment · Phase 3 · Eric Lenze

  Washington University School of Medicine, St Louis · University of Arizona, Tucson

  Registry updated 2026-09-16

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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