Depression: open trials in United States

270 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT06480201
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Trial Treatment · Phase 1 · Texas A&M University
Texas A&M (Houston Methodist Hospital Location), Houston · Wells Medicine, Houston
Registry updated 2026-09-15
NCT07139834
Pattern Separation in Major Depressive Disorder
Trial Treatment · Phase 1 · Jeffrey Miller
New York State Psychiatric Institute (NYSPI), New York
Registry updated 2026-09-15
NCT07217223
Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
Trial Treatment · University of California, San Diego
UCSD Interventional Psychiatry, San Diego
Registry updated 2026-09-15
NCT06096207
DBS for Depression
Trial Treatment · Phase 1 · Northwell Health
Zucker Hillside Hospital, Queens
Registry updated 2026-09-14
NCT07373470
An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.
Trial Treatment · University of Pittsburgh
University of Pittsburgh, Pittsburgh
Registry updated 2026-09-14
NCT04061148
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
Trial Treatment · University of California, San Francisco
San Francisco Veterans Affairs Medical Center, San Francisco
Registry updated 2026-09-11
NCT06580145
Leucine in Midlife Depression
Trial Treatment · Phase 2 · Emory University
Emory University Hospital, Atlanta
Registry updated 2026-09-11
NCT07758010
One-Day cTBS Over the Precuneus
Trial Treatment · Mclean Hospital
McLean Hospital, Belmont
Registry updated 2026-09-11
NCT07105397
Evaluating Conversational Artificial Intelligence for Depression Management
Trial Treatment · George Mason University
George Mason University, Fairfax
Registry updated 2026-09-09
NCT07792252
REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness
Research · Yale University
Yale Greenwich Hospital Interventional Psychiatry Services, Greenwich · Yale New Haven Hospital Interventional Psychiatry Services, New Haven
Registry updated 2026-09-09
NCT07804459
Individualized fMRI-guided TMS for Depression
Trial Treatment · Early phase 1 · University of Pennsylvania
University of Pennsylvania, Philadelphia
Registry updated 2026-09-09
NCT07810023
Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress
Trial Treatment · Endeavor Health
Endeavor Health - Evanston Hospital, Evanston
Registry updated 2026-09-09
NCT07807735
Evaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD)
Trial Treatment · Edward Via Virginia College of Osteopathic Medicine
Auroura Counseling, Washington
Registry updated 2026-09-08
NCT07561307
Optimizing Stimulation Parameters for Electroconvulsive Therapy
Trial Treatment · University of Pennsylvania
Pennsylvania Hospital, Philadelphia
Registry updated 2026-09-04
NCT07772531
A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder
Trial Treatment · Phase 2 · Bristol-Myers Squibb
Atlanta · Boston · Cedarhurst · Cincinnati · Columbus · Dallas · Everett · Gaithersburg · Garden Grove · Glendale · Jacksonville · Lemon Grove · Little Rock · Mount Kisco · Oakland · Oklahoma City · Orlando · Phoenix · Rogers · Staten Island · Upland
Registry updated 2026-09-04
NCT05437705
Decoding and Modulating Affective Brain States
Trial Treatment · University of Pennsylvania
University of Pennsylvania, Philadelphia
Registry updated 2026-09-03
NCT06725277
The OBSERVE Protocol
Research · Yale University
University of Michigan, Ann Arbor · Emory University, Atlanta · Houston Center for Advanced Psychiatric Treatment, Bellaire · Mood Institute, Milford · LifeStance Health, Moore · Athena Care, Nashville · Yale School of Medicine, New Haven · Seattle NTC, Seattle
Registry updated 2026-09-03
NCT07568054
Neural Correlates of Suicidal Behavior in Youth
Trial Treatment · The Cleveland Clinic
The Cleveland Clinic, Cleveland
Registry updated 2026-09-03
NCT04124341
PCS in Severe Treatment Resistant Depression
Trial Treatment · University of Minnesota
University of Minnesota, Minneapolis
Registry updated 2026-09-01
NCT06132581
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Trial Treatment · Florida State University
Florida State University, Tallahassee
Registry updated 2026-08-31
NCT05895747
5-HTP and Creatine for Depression R33 Phase
Trial Treatment · Phase 2 · University of Utah
University of Utah Department of Psychiatry, Salt Lake City
Registry updated 2026-08-27
NCT07544966
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Trial Treatment · Phase 4 · University of North Carolina, Chapel Hill
Carolina Crossing, Chapel Hill · Biomedical Research Imaging Center (BRIC) at UNC, Chapel Hill
Registry updated 2026-08-24
NCT07734701
Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder
Trial Treatment · Phase 2 · Sherwood Brown, MD, PhD
UT Southwestern Medical Center, Dallas · University of Texas at Dallas, Richardson
Registry updated 2026-08-24
NCT07188623
Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression
Trial Treatment · Stanford University
Stanford University, Stanford
Registry updated 2026-08-21
NCT06093906
Positive Processes and Transition to Health (PATH)
Trial Treatment · Case Western Reserve University
Case Western Reserve University, Cleveland · University of Delaware, Newark · University of Washington, Seattle
Registry updated 2026-08-19

All Depression trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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