Diffuse large B-cell lymphoma: open trials in United Kingdom

13 open trials have a site in United Kingdom. Registry data; only the trial team decides who can take part.

NCT06091865
A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma
Trial Treatment · Phase 3 · Regeneron Pharmaceuticals
NHS Grampian - Aberdeen Royal Infirmary, Aberdeen · The Hillingdon Hospitals Nhs Foundation Trust, Uxbridge
Registry updated 2026-11-04
NCT07226843
A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers
Trial Treatment · Phase 1 · Eli Lilly and Company
The Royal Marsden NHS Foundation Trust, London · King's College Hospital, London · Nottingham City Hospital, Nottingham · Derriford Hospital, Plymouth · University Hospital Southampton NHS Foundation Trust, Southampton
Registry updated 2026-11-04
NCT05139017
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
Trial Treatment · Phase 2/3 · Merck Sharp & Dohme LLC
Aberdeen Royal Infirmary ( Site 2104), Aberdeen · University College London Hospital-Cancer Clinical Trials Unit ( Site 2100), London-Camden · The Royal Cornwall Hospital ( Site 2103), Truro
Registry updated 2026-11-03
NCT06890884
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
Stoke Mandeville Hospital ( Site 0917), Aylesbury · Queen Elizabeth Hospital Birmingham ( Site 0912), Birmingham · Bristol Haematology and Oncology Centre ( Site 0908), Bristol · Royal Devon & Exeter Hospital ( Site 0910), Exeter · Lincoln County Hospital ( Site 0906), Lincoln · Clatterbridge Cancer Centre - Liverpool ( Site 0911), Liverpool · Guy s & St Thomas NHS Foundation Trust ( Site 0904), London · Hammersmith Hospital ( Site 0915), London · Christie Hospital NHS Trust ( Site 0901), Manchester · The James Cook University Hospital ( Site 0909), Middlesbrough · Churchill Hospital ( Site 0903), Oxford · University Hospitals Plymouth NHS Trust ( Site 0905), Plymouth
Registry updated 2026-11-03
NCT06395103
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC
Birmingham Children's Hospital-Oncology/Haematology ( Site 1349), Birmingham · University Hospital of Wales ( Site 1346), Cardiff · University College London Hospital ( Site 1350), London · Royal Victoria Infirmary-Great North Children's Hospital ( Site 1348), Newcastle upon Tyne · Royal Marsden Hospital (Sutton)-Drug Development Unit ( Site 1347), Sutton
Registry updated 2026-10-30
NCT05006716
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Trial Treatment · Phase 1/2 · BeOne Medicines
Edinburgh Cancer Centre, Edinburgh · St Jamess University Hospital, Leeds · Freeman Hospital, Newcastle upon Tyne · Genesiscare Cambridge, Newmarket · Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich · Nottingham University Hospitals NHS Trust, Nottingham · Derriford Hospital, Plymouth
Registry updated 2026-10-05
NCT04104776
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
Trial Treatment · Phase 1/2 · Novartis Pharmaceuticals
Royal United Hospital, Department of Oncology/Hematology, Bath · Leicester Royal Infirmary, Leicester · Imperial College Healthcare NHS Trust, London · Royal Marsden Hospital - London, London · The Christie NHS Foundation Trust, Department of Medical Oncology, Manchester · Churchill Hospital, Oxford · University Hospital Southampton NHS Foundation Trust, Southampton · Royal Marsden Hospital (Sutton), Sutton · Musgrove Park Hospital, Taunton
Registry updated 2026-08-19
NCT06980116
Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell Malignancies
Trial Treatment · Phase 1 · Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.
St James's University Hospital, Leeds · University Hospitals Plymouth NHS Trust, Derriford Hospital, Plymouth
Registry updated 2026-08-13
NCT05131022
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
Trial Treatment · Phase 1 · Nurix Therapeutics, Inc.
The Beatson WOS Cancer Center, Glasgow · St James Hospital, Leeds · Clatterbridge Cancer Center NHS Foundation Trust, Liverpool · Sarah Cannon Research Institute UK, London · St. Bartholomew's Hospital, Barts NHS Trust, London · The Christie NHS Foundation Trust, Manchester · Oxford University Hospitals NHS Foundation Trust, Oxford · University Hospitals Plymouth NHS Trust, Plymouth · University Hospital Southampton NHS Foundation Trust, Southampton · Royal Marsden NHS Foundation Trust, Sutton
Registry updated 2026-07-02
NCT06830759
Real-World Study to Assess Subcutaneous Epcoritamab in Adult Participants With Diffuse Large B-Cell and Follicular Lymphoma
Research · AbbVie
NHS Lanarkshire /ID# 276471, Airdrie · Cheltenham General Hospital /ID# 272746, Cheltenham · The Christie /ID# 272745, Manchester · Milton Keynes Hospital /ID# 272817, Milton Keynes · The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 272748, Newcastle upon Tyne · Nottingham City Hospital /ID# 272753, Nottingham · Queen Alexandra Hospital /ID# 272744, Portsmouth · Royal Cornwall Hospital /ID# 272747, Truro
Registry updated 2026-02-17
NCT05107674
A Study of NX-1607 in Adults With Advanced Malignancies
Trial Treatment · Phase 1 · Nurix Therapeutics, Inc.
Addenbrookes Cambridge University Hospital, Cambridge · Beatson West of Scotland Cancer Centre, Glasgow · Sarah Cannon Research Institute, London · The Christie NHS Foundation Trust, Manchester · Northern Centre for Cancer Care, Newcastle · Churchill Hospital, Oxford · Royal Marsden Hospital NHS Foundation Trust, Sutton
Registry updated 2025-09-09
NCT06734624
The Microbiome in Blood Cancer and HLH
Research · University of Nottingham
University of Nottingham, Nottingham
Registry updated 2024-12-16
NCT04502394
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
Trial Treatment · Phase 1/2 · Kartos Therapeutics, Inc.
St James's University Hospital, Leeds · King's College Hospital, London · Royal Marsden Foundation Trust, London · University Hospital Southampton NHS Foundation Trust, Southampton
Registry updated 2022-08-04

All Diffuse large B-cell lymphoma trials and the map

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