Familial hypercholesterolaemia: open trials in Netherlands

10 open trials have a site in Netherlands. Registry data; only the trial team decides who can take part.

2024-514595-41-00
Study to evaluate efficacy and safety of inclisiran in children aged 2 to under 12 years of age with homozygous familial hypercholesterolemia
Trial Treatment · Phase 3 · Novartis Pharma AG
Amsterdam UMC Stichting, Amsterdam
Registry updated 2026-10-26
NCT07473843
Study of Zodasiran in Adolescent Participants With Homozygous Familial Hypercholesterolemia
Trial Treatment · Phase 3 · Arrowhead Pharmaceuticals
Amsterdam UMC Research B.V., Amsterdam
Registry updated 2026-10-26
NCT06451770
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
Trial Treatment · Phase 1 · Verve Therapeutics, Inc.
Clinical Study Center, Amsterdam · Clinical Study Center, Rotterdam
Registry updated 2026-10-23
NCT07058077
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
Trial Treatment · Phase 2/3 · Merck Sharp & Dohme LLC
Amsterdam UMC Stichting, Amsterdam
Registry updated 2026-10-07
NCT05682378
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Amsterdam · Rotterdam
Registry updated 2026-09-18
2023-507489-20-00
Optimizing therapy with n=1-studies: negating the 'nocebo' effect in statin-intolerance
Trial Treatment · Phase 4 · Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Meander Medisch Centrum, Amersfoort · Rijnstate Ziekenhuis Stichting, Arnhem · Albert Schweitzer Ziekenhuis, Dordrecht · Ziekenhuis Gelderse Vallei Stichting, Ede Gld · Radboud Universitair Medisch Centrum (Radboudumc), Nijmegen · Sint Franciscus Vlietland Groep Stichting, Rotterdam · Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), Rotterdam · Maasstad Ziekenhuis Stichting, Rotterdam · Stichting Elisabeth-TweeSteden Ziekenhuis, Tilburg · Universitair Medisch Centrum Utrecht, Utrecht · Isala Klinieken Stichting, Zwolle
Registry updated 2026-08-27
NCT07447648
Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
Research · Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)
Amsterdam University Medical Center, Amsterdam UMC, locatie AMC, Amsterdam · Erasmus University Medical Center, Dr. Molewaterplein 40, Rotterdam
Registry updated 2026-08-21
NCT06597006
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Amsterdam
Registry updated 2026-07-24
NCT06597019
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Amsterdam
Registry updated 2026-05-15
NCT04815005
HoFH, the International Clinical Collaborators Registry
Research · University of Pennsylvania
Department of Vascular Medicine, Amsterdam UMC, Amsterdam
Registry updated 2025-12-18

All Familial hypercholesterolaemia trials and the map

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