Familial hypercholesterolaemia: open trials in South Africa

• NCT06451770

  Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

  Trial Treatment · Phase 1 · Verve Therapeutics, Inc.

  Clinical Study Center, Cape Town · Clinical Study Center, Johannesburg

  Registry updated 2026-10-23

• NCT05682378

  Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies

  Trial Treatment · Phase 3 · Novartis Pharmaceuticals

  Bloemfontein · Cape Town

  Registry updated 2026-09-18

• NCT07775339

  Long-Term Efficacy and Safety of Lerodalcibep in Children and Adolescents With Familial Hypercholesterolemia

  Trial Treatment · Phase 3 · LIB Therapeutics LLC

  IATROS International, Bloemfontein

  Registry updated 2026-08-25

• NCT07102511

  Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children 6 to 17 Years, With Heterozygous FH

  Trial Treatment · Phase 3 · LIB Therapeutics LLC

  IATROS International, Bloemfontein · Lipid Clinic Wits University, Johannesburg

  Registry updated 2026-07-28

• NCT06597006

  Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia

  Trial Treatment · Phase 3 · Novartis Pharmaceuticals

  Bloemfontein · Johannesburg

  Registry updated 2026-07-24

• NCT06597019

  Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia

  Trial Treatment · Phase 3 · Novartis Pharmaceuticals

  Bloemfontein

  Registry updated 2026-05-15

• NCT04815005

  HoFH, the International Clinical Collaborators Registry

  Research · University of Pennsylvania

  Department of Medicine, Division of Lipidology and Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town · c. Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg

  Registry updated 2025-12-18

All Familial hypercholesterolaemia trials and the map

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