Gastric and oesophageal cancer trials in Brazil

In Brazil 22 Also abroad 1285

22 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
Where
Natal, Porto Alegre, São Paulo
Age
18 years and over
People
160 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06469944 · EU 2023-509307-33-00
Phase 1/2Taking people
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
Where
Natal, Porto Alegre, São Paulo
Age
18 years and over
People
298 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06780111 · EU 2024-514273-22-00
Phase 1/2Taking people
A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)
Where
Natal, Porto Alegre
Age
18 years and over
People
60 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07405151 · EU 2026-525213-31-00
Phase 3Taking people
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer
Where
Belo Horizonte, Blumenau, Fortaleza, Jaú, Lages, Porto Alegre, São Caetano do Sul, São José do Rio Preto, São Paulo
Age
18 years and over
People
500 worldwide
Run by
Astellas Pharma Global Development, Inc.
See details and how to joinNCT06901531 · EU 2024-519773-19-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
Where
Belo Horizonte, Fortaleza, Natal, Porto Alegre, Santa Maria, São José do Rio Preto
Age
18 years and over
People
690 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221149 · EU 2025-523263-37-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Barretos, Florianópolis, Jaú, Porto Alegre
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 3Taking people
A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
Where
Barretos, Brasília, Campo Grande, Natal, Porto Alegre, Recife, Salvador, São Paulo, Vitória
Age
18 years and over
People
840 worldwide
Run by
AstraZeneca
See details and how to joinNCT06764875 · EU 2024-512583-57-00
Phase 3Taking people
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
Where
Barretos, Fortaleza, Natal, Porto Alegre, Salvador, Santa Maria, São Paulo, Vitória
Age
18 years and over
People
2,130 worldwide
Run by
AstraZeneca
See details and how to joinNCT07431281 · EU 2024-519787-40-00
Phase 3Taking people
A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
Where
Barretos, Blumenau, Brasília, Natal, Porto Alegre, Recife, Rio de Janeiro, São José do Rio Preto, São Paulo, Vitória
Age
18 years and over
People
351 worldwide
Run by
BeOne Medicines
See details and how to joinNCT07043400 · EU 2025-522862-58-00
Phase 1/2Taking people
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
Where
Natal, Porto Alegre, São Paulo
Age
18 years and over
People
230 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT05319730 · EU 2023-505189-26-00
Phase 1/2Taking people
A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
Where
Barretos, Porto Alegre, Salvador, São José do Rio Preto, São Paulo
Age
18 years and over
People
630 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06427941 · EU 2025-524136-19-00
Phase 2Taking people
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Where
Ijuí, Londrina, Natal, Porto Alegre, Santo André, São Caetano do Sul, Vitória
Age
18 years to 64 years
People
257 worldwide
Run by
AstraZeneca
See details and how to joinNCT06535607 · EU 2025-523947-36-00
Phase 1/2Taking people
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
Where
Natal, Porto Alegre, São Paulo
Age
18 years and over
People
210 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06445972 · EU 2023-509306-29-00
Phase 3Taking people
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
Where
Brasília, Brazil, Florianópolis, Jaú, Natal, Porto Alegre, Recife, Ribeirão Preto, Rio de Janeiro, Salvador, Sao Jose Rio Preto
Age
18 years and over
People
726 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06731478
No phaseTaking people
Comparative Study Between (FC-SEMS) and (PC-SEMS) in the Palliation of Dysphagia Due to Malignant Neoplasm of Esophagus.
Where
São Paulo
Age
18 years and over
People
34
Run by
Instituto do Cancer do Estado de São Paulo
See details and how to joinNCT06070376
No phaseTaking people
Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections
Where
São Paulo
Age
18 years and over
People
30
Run by
Instituto do Cancer do Estado de São Paulo
See details and how to joinNCT06077981
Phase 2Taking people
Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States
Where
Barretos, São Paulo
Age
18 years and over
People
200 worldwide
Run by
Baylor College of Medicine
See details and how to joinNCT06435286
Phase 3Taking people
A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer
Where
Belo Horizonte, Curitiba, Lages, Porto Alegre, Recife, Santa Maria, São Paulo, Vila Mariana
Age
18 years and over
People
550 worldwide
Run by
Shanghai Henlius Biotech
See details and how to joinNCT06532006 · EU 2024-516633-12-00
No phaseNot yet taking people in Brazil
Proteomic Analysis of Patients Undergoing Bariatric Surgery
Where
Recife
Age
18 years and over
People
103
Run by
Universidade Federal de Pernambuco
See details and how to joinNCT06787807
No phaseTaking people
Distribution of Lymph Node Metastases in Esophageal Carcinoma
Where
Rio de Janeiro
Age
18 years and over
People
5,000 worldwide
Run by
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
See details and how to joinNCT03222895
No phaseTaking people
Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach
Where
São Paulo
Age
18 years and over
People
5,000 worldwide
Run by
University of Latvia
See details and how to joinNCT04022109
Phase 2Taking people
Neoadjuvant FOLFIRINOX in the Treatment of Locally Advanced Gastric Cancer
Where
São Paulo
Age
18 years to 75 years
People
27
Run by
Instituto do Cancer do Estado de São Paulo
See details and how to joinNCT03825861