Gastric and oesophageal cancer trials in Canada

In Canada 36 Also abroad 1283

36 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Where
Montreal, Toronto
Age
18 years and over
People
540 worldwide
Run by
Pfizer
See details and how to joinNCT07090499 · EU 2025-521729-33-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
Where
Calgary, Halifax, Sherbrooke, Toronto
Age
18 years and over
People
690 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221149 · EU 2025-523263-37-00
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Halifax, Montreal, Toronto
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
Phase 1Taking people
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Where
Hamilton, Montreal, Toronto
Age
18 years and over
People
421 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07114601 · EU 2025-522367-15-00
Phase 2Taking people
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
Where
Montreal, Toronto
Age
18 years and over
People
100 worldwide
Run by
AstraZeneca
See details and how to joinNCT07069712 · EU 2024-516909-23-00
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Edmonton, Hamilton, Montreal, Ottawa, Toronto
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
No phaseNot yet taking people in Canada
Zolbetuximab and Other Cancer Treatments in People With Advanced Gastric or GEJ Cancer in Clinical Practice (RADIANCE)
Where
Alberta
Age
18 years and over
People
1,000
Run by
Astellas Pharma Europe Ltd.
See details and how to joinNCT07858500
Phase 2Taking people
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Where
Edmonton, Toronto, Vancouver
Age
18 years and over
People
740 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06172478 · EU 2023-507641-29-00
Phase 1Taking people
Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors
Where
Toronto, Vancouver
Age
18 years and over
People
138 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07360314 · EU 2025-523232-39-00
Phase 3Taking people
A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
Where
Barrie, Brampton, Calgary, Chicoutimi, Edmonton, Hamilton, Lévis, Montreal, Toronto, Winnipeg
Age
18 years and over
People
840 worldwide
Run by
AstraZeneca
See details and how to joinNCT06764875 · EU 2024-512583-57-00
Phase 3Taking people
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
Where
Abbotsford British Columbia, Barrie, Brampton, Edmonton, Moncton, Montreal, Ottawa, Québec, Sault Ste. Marie, Toronto, Vancouver, Winnipeg
Age
18 years and over
People
2,130 worldwide
Run by
AstraZeneca
See details and how to joinNCT07431281 · EU 2024-519787-40-00
Phase 2/3Taking people
Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer
Where
London
Age
18 years and over
People
840 worldwide
Run by
Pfizer
See details and how to joinNCT07392892 · EU 2025-524717-86-00
No phaseTaking people
CfDNA in Hereditary And High-risk Malignancies 2
Where
Halifax, Montreal, St. John's, Toronto, Vancouver
Age
Up to 90 years
People
1,000
Run by
University Health Network, Toronto
See details and how to joinNCT06726642
Phase 2Taking people
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
Where
Kingston, Montreal, Sherbrooke, Toronto
Age
18 years and over
People
226 worldwide
Run by
AstraZeneca
See details and how to joinNCT06219941 · EU 2023-508275-37-00
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Montreal, Québec, Toronto
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
Phase 2Taking people
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Where
Edmonton, Montreal
Age
18 years to 64 years
People
257 worldwide
Run by
AstraZeneca
See details and how to joinNCT06535607 · EU 2025-523947-36-00
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Edmonton, Hamilton, Montreal, Ottawa, Toronto, Vancouver
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709
Phase 1/2Taking people
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Where
Toronto
Age
18 years and over
People
366 worldwide
Run by
Marengo Therapeutics, Inc.
See details and how to joinNCT05592626 · EU 2023-505334-10-01
Phase 3Taking people
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
Where
Laval, Mississauga, Montreal, Sherbrooke, Toronto
Age
18 years and over
People
726 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06731478
Phase 1Taking people
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Where
Montreal, Toronto
Age
18 years and over
People
714 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05208762 · EU 2023-506604-18-00
Phase 1Taking people
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Where
Montreal, Ottawa, Toronto
Age
18 years and over
People
914 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT06131840 · EU 2023-505858-18-00
Phase 2Not yet taking people in Canada
RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial
Where
Montreal
Age
18 years and over
People
184
Run by
McGill University Health Centre/Research Institute of the McGill University Health Centre
See details and how to joinNCT07625930
Phase 1Taking people
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
Where
Calgary, Montreal, Toronto
Age
18 years and over
People
694 worldwide
Run by
AbbVie
See details and how to joinNCT05005403
No phaseTaking people
FAZA PETMRI Gastro-Oesophageal Study
Where
Toronto
Age
18 years and over
People
40
Run by
University Health Network, Toronto
See details and how to joinNCT04560036
Phase 1Not yet taking people in Canada
Outside the Cage (OTC) Robotic Esophagectomy
Where
Montreal
Age
18 years and over
People
31
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT06735638