Gastric and oesophageal cancer trials in United States

In United States 272 Also abroad 1285

272 trials · From ClinicalTrials.gov, checked 14 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy
Where
Salt Lake City
Age
18 years and over
People
16
Run by
University of Utah
See details and how to joinNCT04846309
Phase 1/2Taking people
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
Where
East Syracuse, Grand Rapids, Houston, Los Angeles, Louisville, New York, Pittsburgh, Tucson
Age
18 years and over
People
160 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06469944 · EU 2023-509307-33-00
Phase 1/2Taking people
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
Where
Pittsburgh
Age
18 years and over
People
298 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06780111 · EU 2024-514273-22-00
Phase 2/3Taking people
Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity
Where
Albuquerque, Ann Arbor, Atlanta, Aurora, Baltimore, Basking Ridge, Chapel Hill, Chicago, City of Saint Peters, Columbus, Commack, Creve Coeur, Dallas, DeKalb, Derby, Detroit, East White Plains, Fairfield, Fargo, Fort Worth, Gainesville, Geneva, Grand Rapids, Greenwich, Guilford, Hillsborough, Irvine, Kalamazoo, Lexington, Los Angeles, Madison, Marshfield, Menomonee Falls, Middletown, Milwaukee, Mineola, Montvale, Nashville, New Berlin, New Brunswick, New Haven, New Orleans, New York, North Haven, Oak Brook, Oak Creek, Orange, Palo Alto, Philadelphia, Pittsburgh, Portland, Richardson, Rochester, Salt Lake City, Shiloh, Stamford, St Louis, Torrington, Trumbull, Uniondale, Warrenville, Waterbury, Waterford, West Bend, Westerly, Weston, Winston-Salem
Age
18 years and over
People
148
Run by
ECOG-ACRIN Cancer Research Group
See details and how to joinNCT07001748
Phase 1Taking people
Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors
Where
Galveston, Huntersville, New Haven, San Antonio
Age
18 years and over
People
138 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07360314 · EU 2025-523232-39-00
No phaseTaking people
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Where
Bethesda
Age
2 years to 100 years
People
1,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01950572
No phaseTaking people
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Where
Los Angeles
Age
18 years to 99 years
People
360
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT04907643
Phase 2/3Taking people
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
Where
‘Aiea, Albuquerque, Allentown, Anaconda, Anaheim, Ankeny, Ann Arbor, Antigo, Asheboro, Ashland, Atlanta, Aurora, Baldwin Park, Barrington, Bay Shore, Beaver, Bellevue, Bellflower, Bemidji, Berlin Corners, Bethlehem, Beverly Hills, Billings, Bismarck, Bloomington, Boise, Bozeman, Brainerd, Brighton, Brownstown, Buffalo, Burlington, Caldwell, Canton, Cape Girardeau, Carroll, Carthage, Cedar Rapids, Centerville, Charleston, Chelsea, Cherry Hill, Chicago, Cincinnati, City of Saint Peters, Clinton, Clinton Township, Clive, Coeur d'Alene, Colorado Springs, Coon Rapids, Covington, Creve Coeur, Crown Point, Crystal Lake, Cudahy, Cumberland, Danville, Dayton, Dearborn, Decatur, Deer River, DeKalb, Derby, Des Moines, Detroit, Dickson City, Dixon, Downers Grove, Dublin, Duluth, Dyer, East Stroudsburg, Eau Claire, Edina, Effingham, Elgin, Englewood, Erie, Escanaba, Eureka, Evanston, ‘Ewa Beach, Fairfield, Fargo, Farmington, Flint, Fontana, Fort Collins, Fort Dodge, Franklin, Fremont, Fresno, Galesburg, Geneva, Germantown, Glastonbury, Glens Falls, Glenview, Goldsboro, Grafton, Grayslake, Great Falls, Greeley, Green Bay, Greenlawn, Greensboro, Greensburg, Greenville, Greenwich, Guilford, Harbor City, Harrisburg, Hartford, Harvey, Hays, Hazel Crest, Hazleton, Hibbing, Highland Park, Hobart, Honolulu, Houston, Indianapolis, Irvine, Jackson, Jacksonville, Johns Creek, Johnstown, Kalispell, Kansas City, Kenosha, Kewanee, Knoxville, La Jolla, Lake Forest, Lake Success, Lancaster, Lansing, Las Vegas, Lawrence, Lawton, Lewisburg, Lexington, Libertyville, Little Rock, Livonia, Los Angeles, Loveland, Macomb, Madison, Maplewood, Marinette, Marshfield, Mattoon, Mechanicsburg, Medford, Miami Beach, Millville, Milwaukee, Mineola, Minneapolis, Minocqua, Missoula, Modesto, Monroeville, Mount Kisco, Mukwonago, Munster, Nampa, Nashville, Newark, Newberg, New Castle, New Haven, New Lenox, New Orleans, Newport Beach, New York, N. Huntingdon, North Haven, Novi, Oak Brook, Oakland, Oak Lawn, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Olathe, Omaha, Ontario, Oregon City, Orlando, Orland Park, Oshkosh, Ottawa, Panorama City, Park Ridge, Pekin, Peoria, Peru, Philadelphia, Pinehurst, Pittsburgh, Pontiac, Portland, Post Falls, Princeton, Racine, Rapid City, Rehoboth Beach, Reidsville, Reno, Rhinelander, Rice Lake, Richmond, Riverside, Rochester, Rockford, Roseville, Sacramento, Saint Louis Park, Saint Paul, Salina, Salt Lake City, San Diego, Sandpoint, Sandstone, San Francisco, San Jose, San Leandro, San Marcos, San Rafael, Santa Clara, Santa Rosa, Scranton, Seneca, Sewell, Sheboygan, Shiloh, Sioux Falls, Sleepy Hollow, Southfield, South San Francisco, Springfield, Stamford, Stevens Point, St Louis, Sturgeon Bay, Summit, Topeka, Torrington, Troy, Trumbull, Tulsa, Two Rivers, Uniontown, Urbana, Vallejo, Valparaiso, Virginia, Walnut Creek, Warrenville, Washington, Washington D.C., Waterbury, Waterford, Waukee, Waukesha, Wausau, Wauwatosa, West Allis, West Bloomfield, Westerly, Weston, Wilkes-Barre, Williamsville, Willow Grove, Wisconsin Rapids, Woodbury, Woodland Hills, Wyandotte, Ypsilanti
Age
18 years and over
People
224
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06203600
Phase 1Taking people
18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer
Where
Houston
Age
18 years and over
People
60
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06414902
Phase 1Taking people
Nab-Paclitaxel PIPAC in Combination With Paclitaxel and Ramucirumab for the Treatment of Stomach Cancer With Peritoneal Metastases
Where
Duarte
Age
18 years and over
People
30
Run by
City of Hope Medical Center
See details and how to joinNCT06675136
Phase 1/2Taking people
A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)
Where
Pittsburgh
Age
18 years and over
People
60 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07405151 · EU 2026-525213-31-00
Phase 1Taking people
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Where
Austin, Celebration, Denver, Detroit, Duarte, East Brunswick, Fairfax, Fort Worth, Houston, Irvine, Irving, Lake Success, Nashville, New Haven, New York, Plantation, San Antonio, Sarasota, Spokane, West Valley City
Age
18 years and over
People
150 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07503808 · EU 2026-526299-21-00
Phase 1Not yet taking people in United States
A Study of LY4336619 in Adult Participants With Advanced Solid Tumors
Where
Boston, Chicago, Columbus, Duarte, Houston, La Jolla, Lake Success, New York, Scottsdale, West Valley City
Age
18 years and over
People
370 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07928258 · EU 2026-526553-33-00
No phaseTaking people
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis
Where
Bethesda
Age
6 years and over
People
400
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04557969
Phase 2Taking people
GI-05: The Impact of Olanzapine Among Patients Receiving Neoadjuvant Chemotherapy for Gastric Cancer
Where
Chicago
Age
18 years and over
People
26
Run by
University of Illinois Chicago
See details and how to joinNCT07581405
Phase 3Taking people
A Study of ASP2138 Together With Chemotherapy and Pembrolizumab in Adults With Gastric Cancer
Where
Saint Louis Park
Age
18 years and over
People
570 worldwide
Run by
Astellas Pharma Global Development, Inc.
See details and how to joinNCT07673887 · EU 2025-524557-14-00
Phase 1/2Taking people
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
Where
Allentown, Atlanta, Billings, Camden, Chicago, Clermont, Cleveland, Dallas, Detroit, Duarte, El Paso, Fairfax, Glendale, Grand Island, Grand Rapids, Iowa City, Knoxville, La Jolla, Lakewood, Los Angeles, Louisville, Milwaukee, Murrieta, Nashville, Omaha, Orange City, Portland, Saint Louis Park, Saint Paul, San Antonio, Santa Rosa, St Louis, The Bronx, The Woodlands, Tyler
Age
18 years and over
People
340 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT04198766
Phase 2Taking people
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Where
Grand Forks, Jacksonville
Age
18 years and over
People
220
Run by
Mayo Clinic
See details and how to joinNCT05969860
Phase 2Taking people
Avutometinib and Defactinib in Diffuse Gastric Cancer
Where
New York
Age
18 years and over
People
27
Run by
Ryan H. Moy, MD, PhD
See details and how to joinNCT06487221
No phaseTaking people
The Vanguard Study: Testing a New Way to Screen for Cancer
Where
Bethesda, Brownstown, Chapel Hill, Charlottesville, Chesterfield, Cheyenne Wells, Cleveland, Clinton Township, Dearborn, Denver, Detroit, Durham, Fairfax, Fort Collins, Greeley, Grosse Pointe Farms, Honolulu, Kansas City, Lafayette, Livonia, Lone Tree, Loveland, Milwaukee, Minneapolis, Norfolk, Novi, Oklahoma City, Pleasanton, Plymouth, Portsmouth, Richmond, Royal Oak, San Diego, South Hill, Springfield, Sterling Heights, St Louis, Tacoma, Troy, West Bloomfield, Wyandotte
Age
45 years to 75 years
People
24,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06995898
Phase 1/2Taking people
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Where
Ann Arbor, Boston, Cerritos, Fairfax, Hershey, Houston, Indianapolis, Iowa City, Lakeland, Los Angeles, Memphis, Nashville, New Haven, New York, Orange, San Diego, Seattle, Shirley, Sioux Falls, Skokie, Tampa
Age
18 years and over
People
910 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06324357
Phase 1Taking people
A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
Where
Atlanta, Augusta, Austin, Boston, Charlottesville, Dallas, Denver, Fairfax, Fairway, Hackensack, Lake Mary, Little Rock, Los Angeles, Nashville, Orlando, Philadelphia, Pittsburgh, Salt Lake City, San Francisco
Age
19 years and over
People
238 worldwide
Run by
NiKang Therapeutics, Inc.
See details and how to joinNCT06586957
Phase 1Taking people
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
Where
Bethesda
Age
18 years to 120 years
People
120
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06885697
Phase 3Taking people
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer
Where
Ann Arbor, Atlanta, Bakersfield, Baltimore, Birmingham, Boston, Cerritos, Chapel Hill, Chicago, Dallas, Detroit, Durham, Edgewood, Fairfax, Fort Worth, Hartford, Houston, Indianapolis, Iowa City, Knoxville, La Jolla, Los Angeles, Nashville, New Haven, New York, Omaha, Pennington, Pittsburgh, Providence, Saint Louis Park, Salt Lake City, Stony Brook, The Bronx, Washington D.C., Westwood, Worcester
Age
18 years and over
People
500 worldwide
Run by
Astellas Pharma Global Development, Inc.
See details and how to joinNCT06901531 · EU 2024-519773-19-00
Phase 1Taking people
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Where
Boston, Conroe, Duarte, Houston, Irvine, League City, Los Angeles, Nashville, New Haven, Newton, San Antonio, Santa Monica, Sugar Land, Trumbull
Age
18 years and over
People
540 worldwide
Run by
Pfizer
See details and how to joinNCT07090499 · EU 2025-521729-33-00