Glioblastoma: open trials in Germany

26 open trials have a site in Germany. Registry data; only the trial team decides who can take part.

2026-525397-19-00
Synergism of dendritic cell vaccination and anti-PD-L1 immune check-point blockade to sensitize recurrent glioblastoma to anti-tumoral immunity
Trial Treatment · Phase 1 · Heinrich-Heine-Universitaet Duesseldorf
Heinrich-Heine-Universitaet Duesseldorf, Duesseldorf · Sana Kliniken Duisburg GmbH, Duisburg
Registry updated 2026-11-06
NCT03970447
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
Trial Treatment · Phase 2/3 · Global Coalition for Adaptive Research
Universitaetsklinikum Bonn AöR, Bonn · University Hospital Cologne AöR, Cologne · Goethe University Frankfurt, Frankfurt Am Main · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitat Heidelberg, Mannheim · Universitaetsklinikum Regensburg AöR, Regensburg · Universitaetsklinikum Tuebingen AöR, Tuebingen
Registry updated 2026-11-02
NCT07888647
IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade Astrocytomas
Trial Treatment · Phase 2 · German Cancer Research Center
Charité - University Medicine Berlin Department of Neurosurgery, Berlin · University Hospital Bonn Department of Neurooncology, Bonn · University Hospital Cologne Department of Neurology, Cologne · University Hospital Carl Gustav Carus Dresden Department of Neurosurgery, Dresden · University Hospital Erlangen Department of Neurosurgery, Erlangen · University Hospital Essen Department of Neurology Clinical Neuro-Oncology, Essen · University Hospital Frankfurt· Clinic for Neurology - Section Neurooncology, Frankfurt · University Hospital Heidelberg Department of Neurology Division of Neuro-Oncology, Heidelberg · Heidelberg University Faculty of Medicine in Mannheim Department of Neurology, Mannheim · University Hospital Regensburg Neurology, Regensburg · University Hospital Tuebingen Department of Neurology and lnterdisciplinary Neuro-Oncology, Tübingen · University Hospital Ulm Department of Neurology /Center for NeuroOncology, Ulm · University Hospital Wuerzburg Department of Neurosurgery and Outpatient Center, Würzburg
Registry updated 2026-10-22
NCT07867886
An Optimization Study Evaluating Safety and Efficacy of the Y-90 Glioblastoma (GBM) Device in Patients With Recurrent GBM
Trial Treatment · Boston Scientific Corporation
Universitätsklinikum Tübingen, Tübingen
Registry updated 2026-10-09
2024-511264-89-00
Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy (MecMeth/ NOA-24)
Trial Treatment · Phase 2 · Rheinische Friedrich-Wilhelms-Universitaet Bonn
Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum · Universitaetsklinikum Bonn AöR, Bonn · University Hospital Cologne AöR, Cologne · Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR, Dresden · HELIOS Klinikum Erfurt GmbH, Erfurt · Universitätsklinikum Essen, Essen · Goethe University Frankfurt, Frankfurt Am Main · Medical Center- University of Freiburg, Freiburg im Breisgau · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaet Leipzig, Leipzig · Klinikum der Ludwigs-Maximilians-Universität München, Campus Großhadern, München · University Hospital Munster, Münster · Universitaetsklinikum Regensburg AöR, Regensburg · Rostock University Medical Center, Rostock · Universitätsklinikum Tübingen, Tübingen
Registry updated 2026-09-09
NCT05839379
Targeted Pediatric High-Grade Glioma Therapy
Research · Nationwide Children's Hospital
Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg
Registry updated 2026-09-08
NCT06161974
Study of Olutasidenib and Temozolomide in HGG
Trial Treatment · Phase 2 · Rigel Pharmaceuticals
Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg
Registry updated 2026-09-01
NCT07409584
Mental Health and Suicidality in Glioblastoma Patients in Germany
Research · University Hospital, Essen
Charite, Berlin · University Hospital Knappschaftskrankenhaus Bochum, Bochum · University Hospital Essen, Essen · University hospital Hamburg Eppendorf, Hamburg · University Hospital Heidelberg, Heidelberg · University hospital Muenster, Münster
Registry updated 2026-08-27
NCT06954636
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
Research · Sied Kebir
University Hospital Essen, Department of Neurology, Division of Clinical Neuro-Oncology, Essen · Department of Neurosurgery, Münster
Registry updated 2026-08-24
NCT06333899
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Trial Treatment · Early phase 1 · Nationwide Children's Hospital
Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg
Registry updated 2026-06-29
NCT05590689
Radiodynamic Therapy (RDT) With Gliolan in Patients With First Recurrence of Brain Tumor
Trial Treatment · Phase 1/2 · Universität Münster
Universitaet Muenster, Muenster
Registry updated 2026-06-23
NCT04967690
An open-label dose escalation study to estimate maximum tolerated dose (MTD), identify dose-limiting toxicities (DLTs) and study pharmacokinetics following a single dose of intracranially administered temozolomide-based SI-053 as an add-on to the current standard of care (SoC), in adult patients with newly diagnosed glioblastoma (GBM).
Trial Treatment · Phase 1 · Double Bond Pharmaceutical AB
Universitaetsklinikum Aachen AöR, Aachen · University Hospital Cologne AöR, Cologne · University Medical Center Hamburg-Eppendorf, Hamburg
Registry updated 2026-06-16
NCT05904119
Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study
Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC
Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum · University Hospital Cologne AöR, Cologne · Universitaetsklinikum Essen (AoR), Essen · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaetsklinikum Jena KöR, Jena · Klinikum der Universitaet Muenchen AöR, Munich · Universitaetsklinikum Tuebingen AöR, Tuebingen
Registry updated 2026-06-08
NCT06533163
Low-Intensity Oscillatory Magnetic Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) - An Exposure-time Escalation Pilot Trial
Trial Treatment · BioTex, Inc.
University Hospital Bonn, Bonn · University Hospital Leipzig, Leipzig · Clinical Center Lünen, Lünen · Medical Center Mannheim, Mannheim · Technical University of Munich, München · Clinical Center Stuttgart, Stuttgart
Registry updated 2026-06-02
NCT05843253
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Trial Treatment · Phase 2 · Nationwide Children's Hospital
Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg
Registry updated 2026-05-29
NCT04752280
Glioblastoma Radiotherapy Using IMRT or Proton Beams
Trial Treatment · University Hospital Heidelberg
Universitätsklinikum Heidelberg, Heidelberg · Universitätsklinikum Gießen und Marburg, Marburg · Klinikum Stuttgart, Stuttgart
Registry updated 2026-05-27
NCT03383978
Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma
Trial Treatment · Phase 1 · Johann Wolfgang Goethe University Hospital
Goethe University Frankfurt, Frankfurt Am Main · Universitaetsklinikum Heidelberg AöR, Heidelberg · Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR, Mainz · Heidelberg University, Mannheim
Registry updated 2026-04-23
NCT02394626
Surgery for Recurrent Glioblastoma
Trial Treatment · Phase 2 · Insel Gruppe AG, University Hospital Bern
Helios Klinikum Erfurt, Erfurt · Universitätsklinikum Münster, Münster
Registry updated 2026-02-02
NCT07021339
Anterior Temporal Lobectomy in Temporal Glioblastoma
Trial Treatment · Phase 3 · University Hospital, Bonn
University Hospital Bonn, Bonn
Registry updated 2025-06-13
NCT06140875
Amplitude Modulated Radiofrequency Electromagnetic Field Treatment Combined With Radiochemotherapy and Maintenance Chemotherapy in Patients With Glioblastoma (Brain-RF)
Trial Treatment · Charite University, Berlin, Germany
Charité Universitätsmedizin Berlin, Berlin
Registry updated 2025-02-13
NCT06283927
The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)
Research · Jasper Gerritsen
University Hospital Heidelberg, Heidelberg · Technical University Munich, Munich
Registry updated 2024-02-28
NCT06118723
The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)
Research · Jasper Gerritsen
Universitätsklinikum Heidelberg, Heidelberg · Technical University Munich, Munich
Registry updated 2024-02-22
NCT06273176
The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma
Research · Erasmus Medical Center
Universitätsklinikum Heidelberg, Heidelberg · Technical University Munich, Munich
Registry updated 2024-02-22
NCT06146725
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
Research · Jasper Gerritsen
University Hospital Heidelberg, Heidelberg · Technical University Munich, Munich
Registry updated 2023-11-27
NCT06146738
The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)
Research · Jasper Gerritsen
University Hospital Heidelberg, Heidelberg · Technical University Munich, Munich
Registry updated 2023-11-27

All Glioblastoma trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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