Glioblastoma trials in United States

In United States 198 Also abroad 424

198 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Enrolling by invitation
Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma
Where
Iowa City
Age
13 years and over
People
34
Run by
Andrew P. Groves
See details and how to joinNCT06896110
Phase 2Taking people
Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype Glioblastoma
Where
Jacksonville, Rochester, Scottsdale
Age
18 years and over
People
60
Run by
Mayo Clinic
See details and how to joinNCT07708961
Phase 1/2Taking people
Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma
Where
Columbus
Age
18 years to 70 years
People
68 worldwide
Run by
Trogenix ltd
See details and how to joinNCT07346144
Phase 1Taking people
Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas
Where
Duarte
Age
18 years and over
People
24
Run by
City of Hope Medical Center
See details and how to joinNCT07544992
Phase 1Taking people
Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma
Where
Duarte
Age
18 years and over
People
27
Run by
City of Hope Medical Center
See details and how to joinNCT06815029
Early phase 1Taking people
Implantable Microdevice In Primary Brain Tumors
Where
Boston
Age
18 years and over
People
30
Run by
Oliver Jonas
See details and how to joinNCT04135807
Phase 1Taking people
Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment
Where
San Antonio
Age
18 years and over
People
40
Run by
Cerenome
See details and how to joinNCT05460507
Phase 1Taking people
D2C7-IT + 2141-V11 Combination Post-resection in rGBM
Where
Durham
Age
18 years and over
People
46
Run by
Darell Bigner
See details and how to joinNCT06455605
Phase 1/2Taking people
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
Where
Boston, Chicago, Columbus, Fairfax, Houston, Irvine, Jacksonville, Los Angeles, New York, Rochester, Salt Lake City, San Francisco, Scottsdale, Washington D.C.
Age
18 years and over
People
191
Run by
Tango Therapeutics, Inc.
See details and how to joinNCT06810544
Phase 1Taking people
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
Where
Atlanta, Charlotte, Chicago, City of Saint Peters, Columbus, Coral Gables, Coral Springs, Creve Coeur, Deerfield Beach, Doral, Duarte, Fairway, Hollywood, Irvine, Kansas City, La Jolla, Lexington, Madison, Miami, Mineola, Nashville, New Haven, New York, North Miami, Oklahoma City, Orange, Pittsburgh, Plantation, Richmond, Sacramento, Salt Lake City, Shiloh, St Louis, Trumbull, Washington D.C., Westwood, Winston-Salem
Age
18 years and over
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06860594
Phase 1Taking people
A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Clinical Activity of CBX-663 in Participants With Relapsed or Refractory Myeloid Malignancies, Advanced Solid Tumors, or Recurrent or Progressive Glioblastoma.
Where
Duarte, Fairfax, Houston, Tampa
Age
18 years and over
People
120
Run by
Crossbow Therapeutics, Inc.
See details and how to joinNCT07779798
Phase 2Not yet taking people in United States
Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent Glioblastomas
Where
Rochester, St Louis
Age
18 years and over
People
99
Run by
Washington University School of Medicine
See details and how to joinNCT07620548
Early phase 1Taking people
Window of Opportunity Study of Lixumistat in Patients With Newly Diagnosed Glioblastoma
Where
Miami
Age
18 years and over
People
10
Run by
Macarena De La Fuente, MD
See details and how to joinNCT07884344
Phase 3Taking people
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
Where
Atlanta, Aurora, Billings, Birmingham, Boston, Charlottesville, Chicago, Cleveland, Dallas, Detroit, Durham, Fairfax, Gainesville, Houston, Indianapolis, Jacksonville, Kansas City, La Jolla, Lexington, Los Angeles, Madison, Miami, Nashville, New Brunswick, New Haven, Newport Beach, New York, Orlando, Palo Alto, Philadelphia, Phoenix, Pittsburgh, Portland, Rochester, Salt Lake City, San Antonio, San Francisco, Seattle, St Louis, Winston-Salem
Age
18 years and over
People
365 worldwide
Run by
Nuvation Bio Inc.
See details and how to joinNCT05303519
Phase 1/2Taking people
D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients
Where
Durham
Age
18 years and over
People
50
Run by
Darell Bigner
See details and how to joinNCT05734560
Early phase 1Taking people
A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions
Where
Chandler, Phoenix
Age
18 years and over
People
82
Run by
St. Joseph's Hospital and Medical Center, Phoenix
See details and how to joinNCT06072586
Phase 1Taking people
Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
Where
Bethesda
Age
18 years to 120 years
People
28
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06344130
Phase 1/2Taking people
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
Where
Bethesda
Age
18 years to 99 years
People
40
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT07416188
Early phase 1Taking people
Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures
Where
Nashville
Age
18 years and over
People
30
Run by
Eben Rosenthal
See details and how to joinNCT07493447
Phase 2Not yet taking people in United States
The GLIOMAX Study: MT027 Allogeneic CAR-T for Recurrent Glioma
Where
Baltimore
Age
18 years to 70 years
People
40 worldwide
Run by
T-MAXIMUM Pharmaceutical Inc
See details and how to joinNCT07386002
Phase 2Taking people
Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.
Where
Camden
Age
18 years to 80 years
People
70
Run by
The Cooper Health System
See details and how to joinNCT07439172
Phase 1Taking people
TMZ + RT + 5-ALA + LIDU SDT System for Newly Diagnosed Butterfly Glioma
Where
Buffalo
Age
18 years to 80 years
People
30
Run by
Alpheus Medical, Inc.
See details and how to joinNCT07862647
Phase 1/2Taking people
Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells
Where
Los Angeles
Age
18 years and over
People
50
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT06059690
Phase 1/2Taking people
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
Where
Gilbert, Seattle, Tucson
Age
18 years to 99 years
People
30
Run by
University of Arizona
See details and how to joinNCT06814496
Phase 2Not yet taking people in United States
Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma
Where
Birmingham
Age
12 years to 89 years
People
55
Run by
University of Alabama at Birmingham
See details and how to joinNCT07521657