Head and neck cancer: open trials in Belgium

37 open trials have a site in Belgium. Registry data; only the trial team decides who can take part.

2022-501315-13-00
LYSARI – LYmphocyte-Sparing And Radio-Immunotherapy in Head and neck carcinoma - A multicenter, randomised 2*2 factorial design comparing standard to reduced-target volume radiotherapy with or without all-trans retinoic acid (ATRA) in patients with lateralised oropharyngeal, laryngeal and hypopharyngeal squamous cell carcinoma.
Trial Treatment · Phase 3 · Centre Leon Berard
Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe
Registry updated 2026-11-05
NCT04892173
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
Trial Treatment · Phase 3 · Johnson & Johnson Enterprise Innovation Inc.
Cliniques universitaires Saint-Luc, Brussels · Grand Hopital De Charleroi Site Les Viviers, Charleroi · Universitair Ziekenhuis Leuven, Leuven
Registry updated 2026-11-03
NCT07276399
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Universitair Ziekenhuis Antwerpen, Edegem · Chu Helora, La Louvière · UZ Leuven, Leuven · Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe · Vitaz, Sint-Niklaas
Registry updated 2026-11-03
NCT03526835
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Genmab
Institut Jules Bordet, Anderlecht · Universitair Ziekenhuis Gent, Gent · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Namur · Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe
Registry updated 2026-11-02
NCT06788990
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Trial Treatment · Phase 2/3 · Bicara Therapeutics
Ziekenhuis Aan De Stroom, Antwerp · Az St-Jan Brugge-Oostende A.V., Brugge · CHU Helora, Mons · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Namur · Vitaz, Sint-Niklaas · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Yvoir
Registry updated 2026-10-29
NCT06295731
Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
Trial Treatment · Phase 2/3 · Inhibrx Biosciences, Inc
Antwerp University Hospital, Edegem · University Hospital Brussels, Jette · CHU UCL Namur - Site De Sainte-Elisabeth, Namur · Vitaz, Sint-Niklaas
Registry updated 2026-10-28
NCT06172478
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 2 · Daiichi Sankyo
Cliniques universitaires Saint-Luc, Brussels · UZA, Edegem · Universitair Ziekenhuis Gent, Ghent · Universitair Ziekenhuis Brussel, Jette · UZ Leuven, Leuven
Registry updated 2026-10-26
NCT06330064
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Trial Treatment · Phase 1/2 · Daiichi Sankyo
Grand Hopital de Charleroi, Charleroi · Universitair Ziekenhuis Gent, Gent · UZ Leuven, Leuven · Centre Hospitalier Universitaire de Liège, Liège · Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe
Registry updated 2026-10-26
2025-523575-36-00
Phase II study of ezabenlimab in patients with PD-L1-positive head and neck cancer with residual disease detected by ctDNA after chemoradiotherapy
Trial Treatment · Phase 2 · Cliniques Universitaires Saint-Luc
Institut Jules Bordet, Anderlecht · Grand Hopital de Charleroi, Charleroi · Universitair Ziekenhuis Gent, Gent · UZ Brussel, Jette · Chu Helora, La Louvière · UZ Leuven, Leuven · Centre Hospitalier Universitaire de Liège, Liège · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Namur · Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe · Vitaz, Sint-Niklaas
Registry updated 2026-10-14
NCT07807163
A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC
Trial Treatment · Phase 2 · Bicara Therapeutics
AZ Sint-Lucas & Volkskliniek, Gent · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Namur · Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe
Registry updated 2026-10-13
NCT07768189
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
Trial Treatment · Phase 3 · Corbus Pharmaceuticals Inc.
Universitair Ziekenhuis Antwerpen (Uza), Edegem · UZ Gent, Ghent · UZ Leuven - Gasthuisberg Campus, Leuven · Vitaz - Sint-Niklaas Moerland, Sint-Niklaas · Cliniques Universitaires Saint-Luc - Centre du Cancer, Woluwe-Saint-Lambert
Registry updated 2026-10-08
NCT07857096
Rehabilitation Through Individualized Support and Exercise
Trial Treatment · Universitaire Ziekenhuizen KU Leuven
UZ Leuven, Leuven
Registry updated 2026-10-05
NCT05176483
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Trial Treatment · Phase 1 · Exelixis
Algemeen Ziekenhuis Groeninge, Kortrijk
Registry updated 2026-10-01
NCT06129864
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
Trial Treatment · Phase 3 · AstraZeneca
Charleroi · Edegem · Jette · La Louvière · Namur
Registry updated 2026-09-30
NCT05007782
A Phase 1 Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Denikitug (GS-1811), an Afucosylated Anti-CCR8 Monoclonal Antibody, as Monotherapy and in Combination With an Anti–PD-1 Monoclonal Antibody in Adults With Advanced Solid Tumors
Trial Treatment · Phase 1 · Gilead Sciences Inc.
Antwerp University Hospital, Edegem · JESSA Ziekenhuis, Hasselt · UZ Leuven, Leuven
Registry updated 2026-09-21
NCT06970275
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
Research · XEOS Medical
AZORG, Aalst · AZ Maria Middelares, Ghent
Registry updated 2026-09-15
NCT05985655
Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.
GZA Ziekenhuizen - Campus Sint-Augustinus, Antwerp · Clinique Universitaires Saint-Luc, Brussels · Institute Jules Bordet, Brussels · CHU Sart-Tilman, Liège
Registry updated 2026-08-13
NCT05706129
A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 1/2 · Lumara Bio Oncologics GmbH
Institut Jules Bordet, Anderlecht · UZ Leuven, Leuven
Registry updated 2026-08-11
NCT05208762
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Trial Treatment · Phase 1 · Seagen, a wholly owned subsidiary of Pfizer
Institut Jules Bordet, Anderlecht
Registry updated 2026-07-22
NCT05768139
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Eli Lilly and Company
Institut Jules Bordet, Anderlecht · UZ Leuven, Leuven
Registry updated 2026-07-07
NCT05815927
Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer
Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC
Ziekenhuis Aan De Stroom, Antwerp · Ziekenhuis Oost-Limburg, Genk · JESSA Ziekenhuis, Hasselt · Algemeen Ziekenhuis Groeninge, Kortrijk · Chu Helora, La Louvière · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Namur · Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe · Vitaz, Sint-Niklaas
Registry updated 2026-05-28
NCT06256588
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
Trial Treatment · Phase 3 · GlaxoSmithKline
Grand Hopital de Charleroi, Charleroi · Antwerp University Hospital, Edegem · Universitair Ziekenhuis Gent, Gent · Centre Hospitalier Universitaire de Liège, Liège · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Namur · Cliniques Universitaires Saint-Luc, Sint-Lambrechts-Woluwe
Registry updated 2026-05-26
NCT07264075
Study Comparing Ivonescimab Alone or Ivonescimab in Combination With Ligufalimab Versus Pembrolizumab for the Treatment of SCCHN
Trial Treatment · Phase 3 · Groupe Oncologie Radiotherapie Tete et Cou
Grand Hopital De Charleroi Site Les Viviers, Charleroi
Registry updated 2026-05-20
NCT07596355
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
Research · Istituto Italiano di Tecnologia
UZ Leuven, Leuven
Registry updated 2026-05-19
NCT06064877
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Trial Treatment · Phase 3 · AVEO Pharmaceuticals, Inc.
CHU de Liège, Liège · Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur, Namur · Vitaz, Sint-Niklaas
Registry updated 2026-04-09

All Head and neck cancer trials and the map

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