Head and neck cancer: open trials in Canada

58 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT07090499
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Trial Treatment · Phase 1 · Pfizer
McGill University Health Centre, Montreal · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-11-05
NCT04892173
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
Trial Treatment · Phase 3 · Johnson & Johnson Enterprise Innovation Inc.
Sunnybrook Health Sciences Center, Toronto
Registry updated 2026-11-03
NCT06487403
HN-BIO 02: A Phase II Randomized Study of the Effects of Delayed Elective Radiotherapy on Head and Neck MRI and Immune Response Biomarkers
Trial Treatment · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-11-02
NCT06788990
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Trial Treatment · Phase 2/3 · Bicara Therapeutics
Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopital Notre-Dame (Site #0203), Montreal · Sunnybrook Health Sciences Centre (Site # 0204), Toronto · BC Cancer - Vancouver (Site #0202), Vancouver
Registry updated 2026-10-29
NCT06172478
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 2 · Daiichi Sankyo
Cross Cancer Institute, Edmonton · Sunnybrook Research Institute, Toronto · Princess Margaret Cancer Centre, Toronto · BC Cancer - Vancouver, Vancouver
Registry updated 2026-10-26
NCT07888816
Optimizing Response to Immunotherapy With Online Adaptive Pulsed Radiotherapy in Incurable Head and Neck Cancers
Trial Treatment · Phase 2 · University Health Network, Toronto
Princess Margaret Cancer Center, Toronto
Registry updated 2026-10-22
NCT07360314
Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors
Trial Treatment · Phase 1 · EMD Serono Research & Development Institute, Inc.
Princess Margaret Cancer Centre, Toronto · BC Cancer - Vancouver - BC Cancer Agency, Vancouver
Registry updated 2026-10-20
NCT07883005
SALI-10 Probiotic to Reduce Osteoradionecrosis and Dental Toxicity Following Radiation Therapy for Head and Neck Cancer
Trial Treatment · Phase 3 · University Health Network, Toronto
University Health Network, Princess Margaret Hospital, Toronto
Registry updated 2026-10-20
NCT06641791
Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer
Trial Treatment · Phase 3 · Canadian Cancer Trials Group
Arthur J.E. Child Comprehensive Cancer Centre, Calgary · Cross Cancer Institute, Edmonton · Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton · CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal · Ottawa Hospital Research Institute, Ottawa · Hotel-Dieu de Quebec, Québec · University Health Network, Toronto · Odette Cancer Centre, Toronto · BCCA - Vancouver, Vancouver · CancerCare Manitoba, Winnipeg
Registry updated 2026-10-14
NCT07768189
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
Trial Treatment · Phase 3 · Corbus Pharmaceuticals Inc.
Cross Cancer Institute, Edmonton · Verspeeten Family Cancer Centre, London · Jewish General Hospital, Montreal · The Ottawa Hospital Cancer Centre, Ottawa · Allan Blair Cancer Centre, Regina
Registry updated 2026-10-08
NCT04429542
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Trial Treatment · Phase 1 · Bicara Therapeutics
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal · Princess Margaret Cancer Centre, Toronto
Registry updated 2026-10-06
NCT05414032
Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC
Trial Treatment · Phase 2 · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-10-05
NCT07408063
A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)
Trial Treatment · Phase 2 · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-10-01
NCT06129864
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
Trial Treatment · Phase 3 · AstraZeneca
Calgary · Chicoutimi · Edmonton · Kelowna · Kingston · London · Montreal · Regina · Toronto
Registry updated 2026-09-30
NCT03702309
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
Research · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-09-25
NCT05898789
Virtual Rehabilitation for Cancer Survivors
Trial Treatment · University Health Network, Toronto
Princess Margaret Cancer Centre, Toronto
Registry updated 2026-09-24
NCT05172245
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
Trial Treatment · Phase 1 · National Cancer Institute (NCI)
University Health Network, Princess Margaret Hospital, Toronto
Registry updated 2026-09-22
NCT04273061
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
Trial Treatment · Phase 2 · British Columbia Cancer Agency
University Health Network - Princess Margaret Cancer Centre, Toronto · BC Cancer, Vancouver
Registry updated 2026-09-16
NCT06535607
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Trial Treatment · Phase 2 · AstraZeneca
Edmonton · Montreal
Registry updated 2026-09-11
NCT06657222
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Gilead Sciences
Princess Margaret, Toronto
Registry updated 2026-09-11
NCT07090070
Evaluating Treatment Strategies for p53 Mutant Oral Cancer and Oral Cancer Precursors
Trial Treatment · University of British Columbia
Vancouver General Hospital, Vancouver
Registry updated 2026-09-08
NCT04178174
Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer
Trial Treatment · Phase 3 · Centre hospitalier de l'Université de Montréal (CHUM)
London Health Sciences Center, London · Centre Hospitalier de l'Université de Montréal, Montreal
Registry updated 2026-08-24
NCT04901234
Adaptive RadioTherapy for OroPharynx Cancer
Trial Treatment · Phase 2 · Centre hospitalier de l'Université de Montréal (CHUM)
Centre Hospitalier de l'Université de Montréal, Montreal
Registry updated 2026-08-24
NCT07524114
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
Research · University Health Network, Toronto
Princess Margaret Hospital, Toronto
Registry updated 2026-08-21
NCT07241039
A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors
Trial Treatment · Phase 1 · AbbVie
CHUM - Centre hospitalier de l Universite de Montreal /ID# 277586, Montreal · Princess Margaret Cancer Centre /ID# 276852, Toronto
Registry updated 2026-08-19

All Head and neck cancer trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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