Head and neck cancer trials in Canada

In Canada 58 Also abroad 942

58 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
Where
Toronto
Age
18 years and over
People
686 worldwide
Run by
NRG Oncology
See details and how to joinNCT04333537
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Edmonton, Hamilton, Montreal, Ottawa, Toronto, Vancouver
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709
No phaseTaking people
Feasibility of Prospective Surveillance and Early Physical Therapy for Trismus
Where
Edmonton
Age
18 years and over
People
30
Run by
University of Alberta
See details and how to joinNCT06531083
Phase 1/2Taking people
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Where
Toronto
Age
18 years and over
People
366 worldwide
Run by
Marengo Therapeutics, Inc.
See details and how to joinNCT05592626 · EU 2023-505334-10-01
No phaseTaking people
A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers
Where
Toronto
Age
18 years and over
People
60
Run by
University Health Network, Toronto
See details and how to joinNCT06085781
Phase 1Taking people
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Where
Montreal, Toronto
Age
18 years and over
People
714 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05208762 · EU 2023-506604-18-00
Phase 3Taking people
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
Where
Greater Sudbury, Hamilton, Montreal, Sherbrooke, Toronto, Vancouver, Winnipeg
Age
18 years and over
People
510 worldwide
Run by
Canadian Cancer Trials Group
See details and how to joinNCT05451004
Phase 1Taking people
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
Where
Calgary, Montreal, Toronto
Age
18 years and over
People
694 worldwide
Run by
AbbVie
See details and how to joinNCT05005403
No phaseTaking people
Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)
Where
Kingston, Ottawa, Toronto
Age
18 years and over
People
500
Run by
University Health Network, Toronto
See details and how to joinNCT05403177
No phaseTaking people
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
Where
Hamilton, Kingston, London, Ottawa, Toronto
Age
18 years and over
People
10,000
Run by
University Health Network, Toronto
See details and how to joinNCT02906943
No phaseTaking people
Feasibility of Early Swallowing and Speech Intervention for Head and Neck Cancer Patients Treated SURGically
Where
Toronto
Age
18 years and over
People
40
Run by
University Health Network, Toronto
See details and how to joinNCT06192771
Phase 3Taking people
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
Where
Greater Sudbury, Hamilton, Montreal, Toronto
Age
18 years and over
People
864 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06256588 · EU 2023-508613-17-00
Phase 2Not yet taking people in Canada
Staph Nasal Decolonization to Improve Function and Feeding
Where
London
Age
18 years and over
People
126
Run by
David Palma
See details and how to joinNCT07524894
Phase 3Taking people
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Where
Calgary, Edmonton, Montreal, Ottawa, Toronto
Age
18 years and over
People
410 worldwide
Run by
AVEO Pharmaceuticals, Inc.
See details and how to joinNCT06064877 · EU 2023-505606-42-00
No phaseTaking people
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Where
Toronto
Age
18 years and over
People
8,000 worldwide
Run by
UMC Utrecht
See details and how to joinNCT04075305
No phaseTaking people
HN-QUEST: A Study of Head and Neck Imaging Biomarkers
Where
Toronto
Age
18 years and over
People
173
Run by
University Health Network, Toronto
See details and how to joinNCT05919290
No phaseTaking people
Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer
Where
Toronto
Age
18 years and over
People
50
Run by
University Health Network, Toronto
See details and how to joinNCT07348887
No phaseTaking people
Stereotactic Post-operative Radiotherapy for Intraparotid Metastatic Cutaneous Squamous Cell Carcinoma
Where
London
Age
18 years and over
People
90
Run by
David Palma
See details and how to joinNCT07337161
No phaseTaking people
Survivorship After HNC: A Randomized Controlled Trial Evaluating Patient Care and Adherence to Follow-up
Where
London
Age
18 years and over
People
176
Run by
Western University, Canada
See details and how to joinNCT06127784
Phase 1/2Taking people
A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
Where
Toronto
Age
18 years and over
People
300 worldwide
Run by
LigaChem Biosciences, Inc.
See details and how to joinNCT05941507
No phaseTaking people
Proactive Risk-based Optimization & Notifications for Treatment & Outcomes in Head & Neck Cancer
Where
Montreal
Age
18 years and over
People
85
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT07180901
Phase 3Taking people
Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible
Where
Toronto
People
24
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT06055257
No phaseNot yet taking people in Canada
Assessing Spinal Accessory Nerve Recovery After Post-operative Electrical Stimulation
Where
Hamilton
People
38
Run by
McMaster University
See details and how to joinNCT07074392
No phaseTaking people
Low-Dose Weekly vs High-Dose Cisplatin
Where
Hamilton, London, Toronto
Age
18 years and over
People
100
Run by
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
See details and how to joinNCT03649048
Phase 1/2Taking people
Innovative Patient-partner-guided Virtual Group Speech Pathology Intervention Model in Head and Neck Cancer
Where
Montreal
Age
18 years and over
People
76
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT05621889