Head and neck cancer: open trials in Italy

72 open trials have a site in Italy. Registry data; only the trial team decides who can take part.

2022-501315-13-00
LYSARI – LYmphocyte-Sparing And Radio-Immunotherapy in Head and neck carcinoma - A multicenter, randomised 2*2 factorial design comparing standard to reduced-target volume radiotherapy with or without all-trans retinoic acid (ATRA) in patients with lateralised oropharyngeal, laryngeal and hypopharyngeal squamous cell carcinoma.
Trial Treatment · Phase 3 · Centre Leon Berard
Careggi University Hospital, Florence · Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome · Humanitas Mirasole S.p.A., Rozzano · Azienda Ulss 3 Serenissima, Venice
Registry updated 2026-11-05
NCT07276399
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Trial Treatment · Phase 3 · Janssen Research & Development, LLC
Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan · Istituto Europeo di Oncologia s.r.l, Milan · IRCCS Istituto Nazionale Tumori Fondazione Pascale, Naples · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo · Fondazione IRCCS Policlinico San Matteo, Pavia · Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome · Humanitas Mirasole S.p.A., Rozzano
Registry updated 2026-11-03
NCT03526835
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Genmab
ASST Grande Ospedale Metropolitano Niguarda, Milan
Registry updated 2026-11-02
NCT06788990
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Trial Treatment · Phase 2/3 · Bicara Therapeutics
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico, Bologna · ARNAS G. Brotzu, Cagliari · Azienda Ospedaliero-Universitaria Careggi, Florence · Ospedale Vito Fazzi Lecce, Lecce · Azienda Socio Sanitaria Territoriale Santi Paolo E Carlo, Milan · Ospedale San Raffaele S.r.l., Milan · ASST Grande Ospedale Metropolitano Niguarda, Milan · Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan · Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli, Naples · IRCCS Istituto Nazionale Tumori Fondazione Pascale, Naples · Istituto Oncologico Veneto, Padova · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo · Fondazione IRCCS Policlinico San Matteo, Pavia · Azienda Ospedaliero Universitaria Pisana, Pisa · Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome · Ospedale Isola Tiberina - Gemelli Isola, Rome · Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome · Humanitas Mirasole S.p.A., Rozzano · Azienda Ospedaliero Universitaria Senese, Siena
Registry updated 2026-10-29
NCT06953089
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Trial Treatment · Phase 2 · DualityBio Inc.
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia · University Hospital Of Ferrara, Ferrara · Azienda Ospedaliero-Universitaria Careggi, Florence · Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan · Azienda Ospedaliero - Universitaria di Modena, Modena · Fondazione IRCCS Policlinico San Matteo, Pavia · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-10-29
NCT06295731
Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
Trial Treatment · Phase 2/3 · Inhibrx Biosciences, Inc
European Institute of Oncology, Milan · Istituto Nazionale Tumori IRCCS - (National Cancer Institute), Milan · Istituto Nazionale Tumori IRCCS - Fondazione Giovanni Pascale (National Cancer Institute), Naples · Fondazione IRCCS Policlinico San Matteo, Pavia
Registry updated 2026-10-28
NCT06747585
A Study to Investigate ALE.P02 as a Monotherapy or in Combination With Pembrolizumab in Adult Patients With Selected CLDN1+ Solid Tumors
Trial Treatment · Phase 1/2 · Alentis Therapeutics AG
Istituto Clinico Humanitas, Milan · Ospedale San Raffaele, IRCCS, Milan · Istituto Nazionale del Tumori, Fondazione IRCCS, Milan · IEO - Istituto Europeo di Oncologia, IRCCS, Milan · Ospedale Santa Maria delle Croci di Ravenna Oncologia, Ravenna · PU A. Gemelli, Universita Cattolica del Sacro Cuore, Roma · Centro Ricerche Cliniche Verona, Verona
Registry updated 2026-10-28
NCT06172478
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 2 · Daiichi Sankyo
Humanitas Gavazzeni, Bergamo · IRCCS Ospedale Policlinico San Martino, Genova · AOU Federico II - Oncologia Clinica, Naples · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-10-26
NCT06330064
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Trial Treatment · Phase 1/2 · Daiichi Sankyo
Istituto di Candiolo Fondazione del Piemonte per l'oncologia IRCCS, Candiolo · ASST Grande Ospedale Metropolitano Niguarda, Milan · Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan · IRCCS Istituto Nazionale Tumori Fondazione Pascale, Naples · Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome · Humanitas Mirasole S.p.A., Rozzano
Registry updated 2026-10-26
NCT06769698
A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Trial Treatment · Phase 2 · Regeneron Pharmaceuticals
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan · Istituto Europeo di Oncologia, Milan · IRCCS Ospedale San Raffaele, Milan · Humanitas Cancer Center, Pieve Emanuele
Registry updated 2026-10-22
NCT06385132
Psychological and Psychiatric prOfile in Glioblastoma and Head and Neck Cancer
Research · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma
Registry updated 2026-10-14
NCT07129525
Health Oriented Protocol for Epidermal Radiodermatitis
Research · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fondazione Policlinico Universitario Gemelli-IRCCS, Roma
Registry updated 2026-10-14
NCT07807163
A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC
Trial Treatment · Phase 2 · Bicara Therapeutics
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l, Meldola · Ospedale San Raffaele S.r.l., Milan · IRCCS Istituto Nazionale Tumori Fondazione Pascale, Naples
Registry updated 2026-10-13
NCT07768189
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
Trial Treatment · Phase 3 · Corbus Pharmaceuticals Inc.
Ospedali riuniti di Ancona - Clinica di Oncologia Medica, Ancona · Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan · Azienda Ospedaliero-Universitaria di Modena-Policlinico di Modena, Modena · Azienda Ospedaliero Universitaria Pisana - Stabilimento di Santa Chiara, Pisa · Prato Santo Stefano, Prato · Gruppo Humanitas Humanitas Research Hospital Rozzano Cancer Center, Rozzano · Azienda Ospedaliera Universitaria Integrata Verona (AOUI) - Ospedale Borgo Trento, Verona
Registry updated 2026-10-08
NCT04585750
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Trial Treatment · Phase 1/2 · PMV Pharmaceuticals, Inc
Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo · Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan · Humanitas San Pio X, Milan · Istituto Europeo di Oncologia, Milan · ASST Grande Ospedale Metropolitano Niguarda, Milan · IRCCS - lstituto Nazionale Tumori - Fondazione G. Pascale, Naples · Istituti Fisioterapici Ospitalieri - Istituto Nazionale Tumori Regina Elena, Rome · Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome · Istituto Clinico Humanitas, Rozzano
Registry updated 2026-10-02
NCT05176483
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Trial Treatment · Phase 1 · Exelixis
Azienda Ospedaliero-Universitaria delle Marche, Ancona · Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico, Bologna · Careggi University Hospital, Florence · European Institute Of Oncology S.r.l., Milan · IRCCS Istituto Nazionale Tumori Fondazione Pascale, Naples · Azienda Unità Sanitaria Locale della Romagna, Ravenna
Registry updated 2026-10-01
NCT06129864
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
Trial Treatment · Phase 3 · AstraZeneca
Aviano · Florence · Milan · Modena · Naples · Padova · Pavia · Rozzano
Registry updated 2026-09-30
NCT07848061
A Master Regulator of Lipid-Associated Macrophage Function in Cancer
Research · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma
Registry updated 2026-09-29
NCT05983432
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
Trial Treatment · Phase 1 · SystImmune Inc.
Fondazione del Piemonte per l'Oncologia IRCC Candiolo, Candiolo · IRCCS Istituto Clinico Humanitas, Cancer Center, Rozzano
Registry updated 2026-09-21
NCT05059444
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
Research · Guardant Health, Inc.
Instituto Romagnolo per lo Studio dei Tumori "Dino Amadori" IRCCS IRST, SrL, Meldola · Azienda USL IRCCS di Reggio Emilia, Reggio Emilia · Policlinico Universitario Agostino Gemelli, Roma
Registry updated 2026-09-14
NCT06535607
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Trial Treatment · Phase 2 · AstraZeneca
Azienda Ospedaliero-Universitaria Ss.Antonio E Biagio E C.Arrigo Alessandria, Alexandria · Cliniche Gavazzeni S.p.A., Bergamo · Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano
Registry updated 2026-09-11
NCT04895709
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · Bristol-Myers Squibb
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia, Candiolo · Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1, Milan · Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples · Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma · Humanitas, Rozzano · ospedale le scotte-U.O.C. Immunoterapia Oncologica, Siena
Registry updated 2026-08-17
NCT05208762
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Trial Treatment · Phase 1 · Seagen, a wholly owned subsidiary of Pfizer
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico, Bologna · European Institute Of Oncology S.r.l., Milan · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-07-22
NCT07712120
Brief Clinical Psychological Intervention With Biofeedback in Head and Neck Cancer
Trial Treatment · University of Turin, Italy
Head and Neck Cancer Unit, Asl Città di Torino, Turin
Registry updated 2026-07-17
NCT07692360
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
Research · University of Pavia
Maxillo-Facial Surgery and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan · Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia, Pavia
Registry updated 2026-07-09

All Head and neck cancer trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Report an error