Head and neck cancer trials in Italy

In Italy 72 Also abroad 942

72 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
Where
Alexandria, Brescia, Milan, Monza, Pisa, Ravenna, Rome, Verona
Age
18 years and over
People
880 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT05768139 · EU 2023-504807-94-00
Phase 2Not yet taking people in Italy
Phase 2, open-label, multicentre, single-arm study to evaluate the activity of the combination of EGFR inhibitors and c-MET inhibitors in patients with platinum-resistant head and neck squamous cell carcinoma after relapse to immunotherapy.
Where
Bologna, Brescia, Florence, Genoa, Milan, Milano, Padova, Pavia, Rome
Age
18 years and over
People
30
Run by
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
See details and how to join2024-518892-72-00 · EU 2024-518892-72-00
No phaseTaking people
REPROton-HN: Prospective Observational Study on Proton Re-irradiation for Locoregional Recurrences of Head and Neck Tumors
Where
Rozzano
Age
18 years and over
People
50
Run by
Istituto Clinico Humanitas
See details and how to joinNCT07635641
No phaseTaking people
The Role of the Free/Pedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)
Where
Rome
Age
18 years and over
People
102
Run by
Regina Elena Cancer Institute
See details and how to joinNCT06287034
No phaseTaking people
Patients With Human Papillomavirus-associated Head and Neck Cancer for the Discovery of Predictive Biomarkers to Guide Clinical Intervention
Where
Rome
Age
18 years and over
People
40
Run by
Regina Elena Cancer Institute
See details and how to joinNCT06821243
Phase 3Taking people
Pembrolizumab and Radiotherapy for Oligometastatic Head and Neck Cancer
Where
Bologna, Cuneo, Florence, Milan, Naples, Ravenna, Rome, Rozzano
Age
18 years and over
People
200 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT05815927 · EU 2023-504478-39-00
Phase 3Taking people
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
Where
Bologna, Bolzano, Milan, Naples, Padova, Pavia, Prato, Rome, Rozzano, Savona
Age
18 years and over
People
864 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06256588 · EU 2023-508613-17-00
No phaseEnrolling by invitation
p-PHOTOLARYNX- ANTHEM: Photon-Counting CT in Laryngeal Cancer Staging
Where
Rozzano
Age
18 years and over
People
60
Run by
Humanitas University
See details and how to joinNCT07603167
No phaseNot yet taking people in Italy
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
Where
Genova
Age
18 years and over
People
283 worldwide
Run by
Istituto Italiano di Tecnologia
See details and how to joinNCT07596355
No phaseTaking people
Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial
Where
Milan
Age
18 years and over
People
150 worldwide
Run by
Tobias Todsen
See details and how to joinNCT07203911
No phaseTaking people
Extracellular Vesicles and Chemotherapy-Induced Peripheral Neuropathy
Where
Milan
Age
18 years and over
People
120
Run by
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
See details and how to joinNCT07558447
Phase 3Taking people
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Where
Bologna, Florence, Milan, Novara, Padova, Pavia, Rome, Rozzano
Age
18 years and over
People
410 worldwide
Run by
AVEO Pharmaceuticals, Inc.
See details and how to joinNCT06064877 · EU 2023-505606-42-00
No phaseTaking people
Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer Patients
Where
Candiolo
Age
18 years and over
People
52
Run by
Fondazione del Piemonte per l'Oncologia
See details and how to joinNCT07514754
No phaseTaking people
GALENOS 1 in Head and Neck, Lung, and Rectal Cancer Patients
Where
Candiolo
Age
18 years and over
People
110
Run by
Fondazione del Piemonte per l'Oncologia
See details and how to joinNCT07511413
No phaseTaking people
Matching Primary Tumor and Blood Gene Expression Analysis of HPV-negative Squamous Head and Neck Cancers
Where
Milan, Sassari
Age
18 years and over
People
300
Run by
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
See details and how to joinNCT07512921
No phaseTaking people
The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers
Where
Genova, Milan, Pavia, Prato, Roma, Rozzano
Age
18 years and over
People
13,600 worldwide
Run by
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
See details and how to joinNCT05483374
No phaseTaking people
Role of the Immune System in Preventing Laryngeal Cancer
Where
Milan
Age
18 years to 99 years
People
3
Run by
European Institute of Oncology
See details and how to joinNCT07508319
No phaseTaking people
Predicting Toxicity in Elderly Patients With Head and Neck Cancer
Where
Milan
Age
70 years to 99 years
People
3
Run by
European Institute of Oncology
See details and how to joinNCT06344208
No phaseTaking people
Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis
Where
Pavia
Age
18 years and over
People
50
Run by
University of Pavia
See details and how to joinNCT07491536
Phase 2Taking people
Effect of Postbiotics on Microbiota and Systemic Immunomodulation of Pembrolizumab as First-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (RM HNSCC)
Where
Rozzano
Age
18 years and over
People
45
Run by
Gruppo Oncologico del Nord-Ovest
See details and how to joinNCT07485296
No phaseTaking people
Prevention of Oral Mucositis in Head and Neck Cancer.
Where
Roma
Age
18 years and over
People
130
Run by
Catholic University of the Sacred Heart
See details and how to joinNCT05853692
No phaseNot yet taking people in Italy
Development of Patient Derived Xenografts (PDXs) and Analysis of Tyrosine Kinase Receptor Expression in Patients With Squamous Cell Head and Neck Cancer (HNSCC) to Study Resistance Mechanisms Induced by Standard Therapy
Where
Bologna
Age
18 years and over
People
120
Run by
IRCCS Azienda Ospedaliero-Universitaria di Bologna
See details and how to joinNCT07471009
No phaseTaking people
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Where
Brescia, Negrar
Age
18 years and over
People
8,000 worldwide
Run by
UMC Utrecht
See details and how to joinNCT04075305
No phaseTaking people
Impact of Early Response to First-line Anti-PD-1 Monotherapy in Patients With Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma, Assessed by 18F-FDG PET/CT
Where
Rome
Age
18 years and over
People
25
Run by
University of Rome Tor Vergata
See details and how to joinNCT07448727
No phaseTaking people
"Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON)
Where
Pisa
Age
18 years and over
People
400
Run by
University of Pisa
See details and how to joinNCT06336941