Heart failure trials in United States

In United States 387 Also abroad 1265

387 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Reducing Fluid Overload in Heart Failure Patients Using a Non-invasive, Renal Independent System
Where
Asheville, Austin, Greensboro, La Jolla, Minneapolis, New York, Rochester, San Francisco
Age
21 years to 79 years
People
40 worldwide
Run by
AquaPass Medical Ltd.
See details and how to joinNCT06360380
No phaseNot yet taking people in United States
SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome
Where
Pleasanton
Age
18 years and over
People
1,200
Run by
Kaiser Permanente
See details and how to joinNCT07910968
Phase 1/2Taking people
HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction
Where
Dallas, Greenville, Kansas City
Age
18 years and over
People
126
Run by
35Pharma Inc., a GSK company
See details and how to joinNCT07123779
No phaseEnrolling by invitation
EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
Where
Ann Arbor, Aurora, Austin, Boston, Charlotte, Chicago, Cincinnati, Gainesville, Houston, Los Angeles, Milwaukee, New York, Palo Alto, Philadelphia, Salt Lake City, St Louis, Washington D.C.
Age
Up to 21 years
People
40
Run by
Berlin Heart, Inc
See details and how to joinNCT05610787
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Where
Albany, Altamonte Springs, Amarillo, Ann Arbor, Arlington, Asheville, Atlanta, Austin, Aventura, Baltimore, Baton Rouge, Beltsville, Beverly Hills, Birmingham, Bloomfield Township, Boca Raton, Bowie, Boynton Beach, Bradenton, Bridgewater, Conroe, Coral Gables, Covina, Covington, Dallas, Detroit, Dothan, Duncanville, Durham, Elkhart, El Paso, Fairhope, Falls Church, Grand Rapids, Hammond, Hazel Crest, Hialeah, Hollywood, Horsham, Houston, Humble, Huntington Beach, Huntsville, Indianapolis, Inglewood, Inverness, Jackson, Jacksonville, Kalispell, Kansas City, Largo, Lenexa, Lenoir, Lexington, Lincoln, Little Rock, Manassas, Mandeville, Mankato, Maplewood, Marlton, McKinney, Meridian, Milwaukee, Minneapolis, Munster, Newark, Newport Beach, New York, Northridge, Oak Ridge, Ocala, Oklahoma City, Omaha, Orange, Orlando, Ormond Beach, Peachtree City, Pembroke Pines, Pensacola, Phoenix, Pittsburgh, Plano, Pomona, Poughkeepsie, Powell, Puyallup, Rapid City, Richmond, Roanoke, Rochester Hills, Salem, San Diego, San Francisco, Santa Rosa, Sarasota, Sherman, Somerset, Southfield, Stamford, Staten Island, Statesville, Stockton, Tomball, Tucson, Tullahoma, Wellington, Wichita, Wilmington, Winter Park, Yuma
Age
18 years to 99 years
People
5,056 worldwide
Run by
Amgen
See details and how to joinNCT07037459
No phaseTaking people
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
Where
Indianapolis
Age
18 years and over
People
90
Run by
Indiana University
See details and how to joinNCT06388226
Phase 3Taking people
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Where
Amarillo, Arlington Heights, Atlanta, Baltimore, Boca Raton, Bossier City, Brandon, Bridgeport, Bridgewater, Chicago, Chula Vista, Clearwater, Coeur d'Alene, Columbus, Dallas, Daytona Beach, Dearborn, Elkhart, Fort Worth, Gainesville, Greensboro, Greenville, Hallandale, Hammond, Hazel Crest, Indianapolis, Jackson, Jacksonville, Jefferson City, Johns Creek, Kansas City, Katy, Kingwood, Lansing, Largo, Libertyville, Lincoln, Longview, Louisville, Madison, Manalapan, Manassas, Marion, McKinney, Merrillville, Miami, Minneapolis, Miramar Beach, Mobile, Munster, Naples, New York, Norfolk, North Kansas City, Ocala, Orange, Park Ridge, Port Charlotte, Raleigh, Rapid City, Richmond, Saint Augustine, Salt Lake City, San Dimas, Santa Clarita, Seattle, Shreveport, Slidell, Somerset, Southfield, St Louis, Tampa, The Bronx, Toledo, Tustin, Waukesha, Wellington, Wesley Chapel, West Des Moines, Wichita, Winchester, Winter Park, Ypsilanti
Age
18 years and over
People
6,712 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06424288 · EU 2023-509706-30-00
Phase 3Taking people
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Where
Amarillo, Arlington Heights, Atlanta, Baltimore, Beaumont, Beltsville, Beverly Hills, Bloomfield Hills, Brandon, Bridgewater, Cleveland, Covina, Cypress, Dallas, Daytona Beach, Doral, Elkhart, Encinitas, Farmington Hills, Fort Worth, Gainesville, Greenville, Hallandale, Hammond, Hazel Crest, Houston, Indianapolis, Irving, Jacksonville, Johns Creek, Kansas City, Lanham, Lenoir, Libertyville, Longview, Manassas, Marion, McKinney, Merced, Merrillville, Miami, Miami Lakes, Minneapolis, Munster, Newport Beach, New York, Northridge, Omaha, Palmetto Bay, Park Ridge, Pinehurst, Port Charlotte, Richmond, Roanoke, Rochester, Saint Augustine, Saint Paul, San Diego, Santa Clarita, Shreveport, Southfield, Springfield, Statesville, St Louis, Tampa, Thousand Oaks, Tomball, Waco, Wellington, Wesley Chapel, West Des Moines, Wichita, Wilmington, Winter Park, Yardley, Ypsilanti
Age
18 years and over
People
4,200 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06935370 · EU 2024-519525-38-00
No phaseTaking people
Cardiogenic Shock Working Group Registry
Where
Boston, Chicago, Dallas, Falls Church, Galveston, Hackensack, Houston, New York, Pittsburgh, Portland, Seattle, Weston
Age
18 years and over
People
20,000
Run by
Tufts Medical Center
See details and how to joinNCT04682483
No phaseTaking people
CCM OPEN HF Registry
Where
Ann Arbor, Boston, Browns Mills, El Paso, Germantown, Hackensack, Haddon Heights, Kansas City, Londonderry, Lynchburg, Mesa, Milwaukee, Minneapolis, Newark, Novi, Oklahoma City, Orlando, Phoenix, Portland, Surprise, Tampa, Tyler, Vancouver, West Reading, Ypsilanti
Age
18 years and over
People
5,500
Run by
Impulse Dynamics
See details and how to joinNCT07112924
Phase 3Taking people
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Ann Arbor, Atlanta, Aurora, Boston, Cincinnati, Cleveland, Columbus, Dallas, Gainesville, Hollywood, Houston, Indianapolis, Kansas City, New York, North Charleston, Philadelphia, Pittsburgh, Salt Lake City, St Louis, The Bronx, Wilmington
Age
Up to 18 years
People
117 worldwide
Run by
Bayer
See details and how to joinNCT07192952 · EU 2024-519830-22-00
No phaseTaking people
Voice-based Outcome Identification and Clinical Evaluation in Heart Failure
Where
Boston
Age
22 years and over
People
450
Run by
Noah Labs
See details and how to joinNCT07870395
No phaseTaking people
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
Where
Boston
Age
18 years to 100 years
People
60
Run by
Tufts Medical Center
See details and how to joinNCT06253104
No phaseTaking people
Assessment of CCM in HF With Higher Ejection Fraction
Where
Ann Arbor, Austin, Birmingham, Boston, Bryn Mawr, Buffalo, Camden, Cleveland, Columbus, Cutler Bay, Dallas, Danbury, Detroit, Fort Worth, Gainesville, Germantown, Greenville, Haddon Heights, Hartford, Hershey, Houston, Indianapolis, Iowa City, Kansas City, La Jolla, Lexington, Lincoln, Los Angeles, Manchester, Mesa, Miami, Minneapolis, Morristown, Northridge, Orlando, Philadelphia, Piscataway, Pittsburgh, Pomona, Portland, Poughkeepsie, Redwood City, Richmond, Scottsdale, Seattle, Sioux Falls, Southfield, Tulsa, Tuscon, Vancouver, West Des Moines, Weston, Ypsilanti
Age
18 years and over
People
1,500
Run by
Impulse Dynamics
See details and how to joinNCT05064709
No phaseTaking people
Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
Where
Houston, Indianapolis, Philadelphia, Tulsa
Age
18 years and over
People
270 worldwide
Run by
VisCardia Inc.
See details and how to joinNCT06552637
Phase 2Taking people
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Where
Baltimore, Beverly Hills, Bowie, Brownsville, Chicago, Evanston, Fort Wayne, Fort Worth, Hazel Crest, Jacksonville, Lake Forest, Lima, Lincoln, McKinney, Miami, North Miami Beach, Pembroke Pines, Richmond, Santa Maria, Tomball, Winter Park
Age
18 years to 79 years
People
620 worldwide
Run by
Pfizer
See details and how to joinNCT06991257 · EU 2024-518438-94-00
No phaseTaking people
Mobile Health Intervention to Increase Activity in Heart Failure Study
Where
Ann Arbor
Age
18 years and over
People
50
Run by
University of Michigan
See details and how to joinNCT07750262
No phaseTaking people
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
Where
Portland
Age
18 years and over
People
200
Run by
Oregon Health and Science University
See details and how to joinNCT06461962
No phaseTaking people
Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)
Where
Augusta, Chicago, Nashville, Victorville
Age
21 years and over
People
125 worldwide
Run by
Bodyport Inc.
See details and how to joinNCT07059962
No phaseTaking people
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
Where
Columbus
Age
18 years and over
People
1,000
Run by
Arunark Kolipaka
See details and how to joinNCT01757730
Phase 3Taking people
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Where
Abilene, Albany, Albuquerque, Alexandria, Anchorage, Arlington, Atlanta, Aurora, Austin, Baltimore, Beaumont, Beavercreek, Beltsville, Birmingham, Boca Raton, Bossier City, Boston, Bridgeport, Brooklyn, Brownsville, Burke, Burlington, Camp Hill, Canton, Carson City, Centreville, Champaign, Charlotte, Charlottesville, Chicago, Cincinnati, Clearfield, Cleveland, Columbia, Columbus, Concord, Cordele, Crystal River, Dallas, Daly City, Dayton, Dublin, Duncanville, Durham, Eatontown, El Dorado, El Paso, Englewood, Fairfax, Fairhope, Falls Church, Fargo, Farmington Hills, Fayetteville, Flint, Fort Lauderdale, Fort Mill, Fort Myers, Franklinton, Gainesville, Gilbert, Glendale, Goose Creek, Green Bay, Greenville, Gurnee, Horsham, Houston, Huntington Beach, Huntsville, Idaho Falls, Indianapolis, Inglewood, Island Lake, Jacksonville, Kalispell, Kansas City, Kernersville, Kingwood, Kinston, La Jolla, Lakeland, Lakewood, Lenexa, Lewisville, Lexington, Lincoln, Loma Linda, Los Angeles, Louisville, Lutherville-Timonium, Manassas, Mankato, Mansfield, Massapequa, Maumee, McAllen, Medford, Mesquite, Miami, Miami Lakes, Midlothian, Milwaukee, Minneapolis, Missoula, Mobile, Monroe, Morganton, Morgantown, Morristown, Mt. Pleasant, Munster, Nashville, New Bedford, New Bern, Newton, New York, Norfolk, Norman, North Charleston, Ocoee, Ogden, Oklahoma City, Olla, Omaha, Orlando, Owensboro, Paducah, Palmetto Bay, Paris, Park Ridge, Pearland, Pennington, Philadelphia, Portsmouth, Potomac, Puyallup, Queens Village, Raleigh, Redmond, Renton, Richmond, Riverview, Rocky Mount, Roslindale, Sacramento, Saint Augustine, Salem, San Antonio, San Diego, San Dimas, San Francisco, Santa Maria, Scottdale, Sheffield, Sherman Oaks, Shreveport, Smithfield, Somerset, South Bend, Spartanburg, Stamford, Stephenville, St Louis, Sugar Land, Suwanee, Tempe, Thousand Oaks, Toledo, Tomball, Troy, Tucker, Tucson, Vestavia Hills, Victoria, Waterbury, Weslaco, West Chester, Wichita, Wilmington, Woodstock, Woodway, Ypsilanti
Age
40 years and over
People
11,300 worldwide
Run by
AstraZeneca
See details and how to joinNCT06677060 · EU 2024-514506-32-00
Phase 3Taking people
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Where
Abington, Allentown, Ann Arbor, Austin, Baltimore, Boston, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Detroit, Durham, Falls Church, Farmington Hills, Gainesville, Glenview, Greenville, Hershey, Honolulu, Houston, Indianapolis, Kansas City, La Jolla, Lancaster, Los Angeles, Manhasset, Murray, Nashville, New Haven, New Orleans, New York, Norfolk, Omaha, Orange, Pasadena, Philadelphia, Phoenix, Plano, Portland, Richmond, Rochester, Rosedale, San Francisco, Santa Rosa, Spokane, Stanford, St Louis, The Bronx, Tupelo, Washington D.C.
Age
18 years and over
People
1,280 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07207811
Early phase 1Taking people
Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
Where
Minneapolis
Age
60 years and over
People
80
Run by
University of Minnesota
See details and how to joinNCT06507657
No phaseTaking people
Fluid Guided Heart Failure Treatment at the Cleveland Clinic
Where
Cleveland
Age
21 years and over
People
50
Run by
Bodyport Inc.
See details and how to joinNCT07205120
Phase 3Enrolling by invitation
Long-Term Open-Label Extension Study of Oral Levosimendan
Where
Boston, Charleston, Chicago, Durham, Madison, Minneapolis, New York, Omaha, Rochester, St Louis
Age
18 years and over
People
800
Run by
Tenax Therapeutics, Inc.
See details and how to joinNCT07436689