Hypertrophic cardiomyopathy: open trials in Netherlands

• NCT07023614

  A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

  Trial Treatment · Phase 2 · Imbria Pharmaceuticals, Inc.

  Amsterdam-Zuidoost · Leiden · Nijmegen · Rotterdam

  Registry updated 2026-10-26

• 2024-515125-28-00

  A randomized, double-blinded, placebo-controlled trial to evaluate the efficacy and safety of ninerafaxstat in patients with symptomatic non-obstructive hypertrophic cardiomyopathy

  Trial Treatment · Phase 2 · Imbria Pharmaceuticals Inc.

  Amsterdam UMC Research B.V., Amsterdam · Leids Universitair Medisch Centrum (LUMC), Leiden · Radboud universitair medisch centrum Stichting, Nijmegen · Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), Rotterdam

  Registry updated 2026-10-19

• NCT04848506

  Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

  Trial Treatment · Phase 2/3 · Cytokinetics

  Academisch Medisch Centrum, Amsterdam · Universiteit Maastricht, Maastricht · Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), Rotterdam

  Registry updated 2026-10-13

• 2025-523090-42-00

  LEAF‑HCM: What can we learn from the early use of aficamten in people who have no symptoms but do have a thickened heart muscle with blood flow obstruction?

  Trial Treatment · Phase 2 · Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

  Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), Rotterdam

  Registry updated 2026-09-29

All Hypertrophic cardiomyopathy trials and the map

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