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Hypertrophic cardiomyopathy: open trials in United States

22 open trials have a site in United States. Registry data; only the trial team decides who can take part.

  • NCT07806149

    NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices

    Trial Treatment · National Heart, Lung, and Blood Institute (NHLBI)

    Emory University Hospital, Atlanta · Beth Israel Deaconess Medical Center, Boston · Univ. of Virginia, Charlottesville · Carilion Roanoke Memorial Hospital, Roanoke · St. Francis Hospital & Heart Center, Roslyn · Montefiore Medical Center-Einstein Campus, The Bronx · MedStar Washington Hospital Center, Washington D.C. · Wellspan York Hospital, York

    Registry updated 2026-11-06

  • NCT07867288

    Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HTX-001

    Trial Treatment · Phase 1 · Haya Therapeutics, Inc.

    Lahey Clinic, Boston · The Lindner Research Center at the Christ Hospital, Cincinnati · Saint Luke's Health System, Kansas City

    Registry updated 2026-11-04

  • NCT07023614

    A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

    Trial Treatment · Phase 2 · Imbria Pharmaceuticals, Inc.

    Atlanta · Baltimore · Boston · Burlington · Charlotte · Charlottesville · Chicago · Grand Rapids · Houston · La Jolla · Los Angeles · Miami · Milwaukee · New York · Oak Lawn · Philadelphia · Plano · Portland · Richmond · Rochester · Salt Lake City · San Francisco · St Louis · Washington D.C.

    Registry updated 2026-10-26

  • NCT07054073

    HCMR Re-Imaging Study

    Research · Christopher Kramer

    University of Michigan, Ann Arbor · Brigham & Women's Hospital, Boston · University of Virginia, Charlottesville · Cleveland Clinic, Cleveland · Tufts Medical Center, Medford · Mayo Clinic, Rochester

    Registry updated 2026-10-16

  • NCT04848506

    Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

    Trial Treatment · Phase 2/3 · Cytokinetics

    Alaska Heart and Vascular Institute, Anchorage · Michigan Medicine - University of Michigan, Ann Arbor · University of Michigan Health System (UMHS) - University Hospital (University of Michigan Medical Center), Ann Arbor · Emory Clinic, Atlanta · University of Alabama at Birmingham, Birmingham · Brigham and Women's Hospital, Boston · Massachusetts General Hospital, Boston · Lahey Hospital & Medical Center, Burlington · Medical University of South Carolina, Charleston · Sanger Heart & Vascular Institute, Atrium Health, Charlotte · University of Virginia Health System University Hospital, Charlottesville · Northwestern University, Chicago · The Linder Research Center at The Christ Hospital, Cincinnati · University Hospitals Cleveland Medical Center*, Cleveland · Cleveland Clinic, Cleveland · The University of Texas Southwestern Medical Center at Dallas, Dallas · Henry Ford Hospital, Detroit · Duke Cardiology at Southpoint, Durham · Inova Health Care Services, Falls Church · Piedmont Fayette Hospital, Fayetteville · Holy Cross Hospital / Cardiology Associates, Fort Lauderdale · Greenville Memorial Hospital, Greenville · The Queen's Medical Center, Honolulu · CHI St. Luke's Health Baylor College of Medicine Medical Center, Houston · Houston Methodist Hospital, Houston · The University of Iowa Hospitals & Clinics, Iowa City · The University of Kansas Medical Center, Kansas City · Saint Luke's Hospital of Kansas City, Kansas City · UC San Diego Health-Sulpizio Cardiovascular Center, La Jolla · Cedars-Sinai Medical Center (Smidt Heart Institute), Los Angeles · Cedar Sinai Medical Center, Los Angeles · UCLA Health System - UCLA Cardiovascular Center, Los Angeles · Northwell Health North Shore University Hospital, Manhasset · Aurora St. Luke's Medical Center, Milwaukee · University of Minnesota, Minneapolis · WVUMedicine, Morgantown · Morristown Medical Center, Morristown · Intermountain Medical Center, Murray · Vanderbilt University Medical Center, Nashville · Ascension Saint Thomas Heart West, Nashville · Yale New Haven Hospital, New Haven · Columbia University Medical Center/New York-Presbyterian Hospital, New York · Mount Sinai Hospital, New York · Weill Cornell Medicine, New York · NYU Langone Health, New York · Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine), Philadelphia · Mayo Clinic Building-Phoenix, Phoenix · UPMC Presbyterian, Pittsburgh · Providence St. Vincent Medical Center, Portland · Oregon Health Science University, Portland · Mayo Clinic, Rochester · University Of Utah Health, Salt Lake City · UCSF Medical Center, San Francisco · Virginia Mason Medical Center, Seattle · Ascension St. John Clinical Research Institute, Tulsa · Westchester Medical Center, Valhalla · MedStar Washington Hospital Center, Washington D.C.

    Registry updated 2026-10-13

  • NCT06092034

    A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease

    Trial Treatment · Phase 2 · Rocket Pharmaceuticals Inc.

    Boston Children's Hospital, Boston · University of California San Diego, La Jolla · Children's Hospital of Philadelphia, Philadelphia

    Registry updated 2026-10-06

  • NCT07755904

    BHB-1893 Versus Metoprolol for Symptomatic Obstructive Hypertrophic Cardiomyopathy

    Trial Treatment · Phase 3 · Braveheart Bio, Inc.

    Manhasset · Plano · Rock Hill

    Registry updated 2026-10-02

  • NCT07721025

    Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy

    Trial Treatment · Phase 2 · Lexeo Therapeutics

    University of South Florida, Tampa

    Registry updated 2026-09-02

  • NCT05489705

    A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

    Research · Bristol-Myers Squibb

    Alaska Heart Institute, Anchorage · UC Denver, AMC, Aurora · MedStar Health Research Institute, Baltimore · Baltimore · St. Luke's University Health Network, Bethlehem · Harvard (Massachusetts General Hospital), Boston · Harvard Medical School - Brigham and Women's Hospital (BWH), Boston · Focus Clinical Research, Charlotte · The Rector and Visitors of the Univ of Virginia, Charlottesville · University of Chicago Dept of Medicine, Chicago · Christ Hospital Health Network, Cincinnati · University Hospitals Cleveland Medical Center*, Cleveland · Cleveland · Bassett Medical Center, Cooperstown · Baylor Scott & White Research Institute, Dallas · North Texas Cardiology Center, Dallas · Duke University Health System, Durham · Spectrum Health Medical Group, Grand Rapids · Prisma Health-Upstate, Greenville · Hackensack University Medical Center, Hackensack · Hartford · Honolulu · BI Research Center, Houston · The Methodist Hospital, Methodist Cancer Cencer, Houston · Indiana University, Indianapolis · Franciscan Physician Network, Indiana Heart Physicians, Indianapolis · Iowa City · Jacksonville · Kansas City · St. Luke's Mid-America Heart Institute, Kansas City · La Jolla · Lancaster · UAMS, Little Rock · Keck School of Medicine of USC-Usc, Los Angeles · Madison · Medical College of Wisconsin, Inc (PI Address), Milwaukee · Minneapolis Heart Institute Foundation, Minneapolis · WVU Hospitals, Morgantown · Morristown · Tristar Centennial Medical Ctr, Nashville · Saint Thomas Health, Nashville · New York · Mount Sinai Hospital, New York · CHI Health Reseach Center, Omaha · Stanford Health Care Hospital & Clinics, Palo Alto · University of Pittsburgh, Pittsburgh · Baylor Scott & White The Heart Hospital - Plano, Plano · VCU Medical Center, Richmond · Carilion Clinic-Virginia Tech, Carilion School of Medicine, Roanoke · Saint Francis Hospital, Roslyn · University of California San Francisco Medical Center, San Francisco · Virginia Mason Medical Center, Seattle · Washington University, St Louis · Baylor Scott & White Medical Centre - Temple, Temple · PIMA Heart and Vascular, Tucson · Cardiology Associates Research, LLc, Tupelo · WMCHealth Advanced Physician Services, Valhalla · MedStar Washington Hospital Center, Washington D.C. · Henry Ford Health System, West Bloomfield · Geisinger Health System, Wilkes-Barre

    Registry updated 2026-08-19

  • NCT07420907

    Registry updated 2026-08-12

  • NCT06610019

    Cardiovascular Multimodality Imaging Study

    Research · Montefiore Medical Center

    Montefiore Health System, The Bronx

    Registry updated 2026-08-10

  • NCT02432092

    Pediatric Cardiomyopathy Mutation Analysis

    Research · Indiana University

    IU School of Medicine, Indianapolis

    Registry updated 2026-06-22

  • NCT06034405

    Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

    Research · Columbia University

    Cedars-Sinai Medical Center, Beverly Hills · Boston Medical Center, Boston · Tufts Medical Center, Boston · Cleveland Clinic, Cleveland · Columbia University Irving Medical Center, New York · Mayo Clinic, Rochester

    Registry updated 2026-06-04

  • NCT07600177

    Mavacamten to Aficamten Transition in Patients With Obstructive Hypertrophic Cardiomyopathy

    Trial Treatment · Phase 4 · Oregon Health and Science University

    St. Luke's Hospital - Mid America Heart Institute, Kansas City · Oregon Health Science University, Portland

    Registry updated 2026-05-20

  • NCT05836259

    Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

    Trial Treatment · Phase 1/2 · Tenaya Therapeutics

    Emory University, Atlanta · Brigham and Women's Hospital, Boston · The Christ Hospital Physicians - The Ohio Heart and Vascular Center, Cincinnati · Cleveland Clinic, Cleveland · Houston Methodist Hospital, Houston · UC San Diego Altman Clinical and Translational Research Institute - Center for Clinical Research, La Jolla · Hospital of the University of Pennsylvania, Philadelphia · Oregon Health Science University, Portland · Mayo Clinic, Rochester · University of California San Francisco, San Francisco

    Registry updated 2026-03-19

  • NCT06433050

    Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy

    Trial Treatment · Early phase 1 · University of Pennsylvania

    University of Pennsylvania, Philadelphia

    Registry updated 2026-02-11

  • NCT02413450

    Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias

    Research · Johns Hopkins University

    Johns Hopkins Medical Institute, Baltimore

    Registry updated 2026-01-16

  • NCT05818605

    Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy

    Trial Treatment · University of California, San Francisco

    University of California San Francisco, San Francisco

    Registry updated 2025-11-20

  • NCT05939700

    Mavacamten Pregnancy Surveillance Program

    Research · Bristol-Myers Squibb

    The Mavacamten Pregnancy Surveillance Program, PPD Inc, Wilmington

    Registry updated 2025-11-06

  • NCT06935253

    Large Language Models To Improve the Quality of Care of Cardiology Patients

    Trial Treatment · Stanford University

    Stanford, Palo Alto

    Registry updated 2025-05-15

  • NCT06551129

    Real-world Patient Reported Outcomes Among Patients Treated With Camzyos

    Research · Bristol-Myers Squibb

    Analysis Group, Inc., Boston

    Registry updated 2024-11-07

  • NCT06023186

    Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCM

    Research · Michael Ayers

    University of Virginia, Charlottesville

    Registry updated 2024-11-06

All Hypertrophic cardiomyopathy trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Under construction, not live – Hypertrophic cardiomyopathy trials in United States – Frontlight Research