Liver and biliary tract cancer trials in United Kingdom

In United Kingdom 45 Also abroad 1314

45 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Evaluation of Combined Modality Protons and Hepatic Transplantation for Hilar Cholangiocarcinoma
Where
London, Manchester
Age
17 years and over
People
30
Run by
The Christie NHS Foundation Trust
See details and how to joinNCT06434493
Phase 2Taking people
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
Where
Edinburgh, London, Manchester
Age
18 years to 100 years
People
104 worldwide
Run by
CatalYm GmbH
See details and how to joinNCT07219459 · EU 2025-520675-86-00
Phase 2Taking people
A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement
Where
London, Manchester
Age
18 years and over
People
30 worldwide
Run by
Elevar Therapeutics
See details and how to joinNCT07359820
No phaseTaking people
A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice
Where
Birmingham, Guildford, Leeds, Middlesbrough, Norfolk
Age
18 years and over
People
700 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07284121
Phase 1/2Taking people
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Where
Coventry, London
Age
18 years and over
People
220 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06428409 · EU 2023-508703-21-00
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Cardiff, Dundonald, London, Sutton
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
Phase 1Taking people
A Study of MGC026 in Participants With Advanced Solid Tumors
Where
Oxford, Sutton
Age
18 years and over
People
394 worldwide
Run by
MacroGenics
See details and how to joinNCT06242470
Phase 3Taking people
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Where
Edinburgh, London, Manchester, Surrey
Age
18 years and over
People
286 worldwide
Run by
Jazz Pharmaceuticals
See details and how to joinNCT06282575 · EU 2023-508219-21-00
Phase 1/2Taking people
A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)
Where
Glasgow, London, Metropolitan Borough of Wirral
Age
18 years and over
People
198 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07291076 · EU 2025-523602-33-00
No phaseTaking people
Breath Research Narrow Validation for Gastrointestinal Cancer Detection
Where
Glasgow, Liverpool, London, Maidstone
Age
18 years and over
People
1,000
Run by
Imperial College London
See details and how to joinNCT07714538
Phase 1Taking people
A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer
Where
Glasgow, London, Sutton
Age
18 years and over
People
148 worldwide
Run by
Bayer
See details and how to joinNCT06764316 · EU 2024-516615-25-00
Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease
Where
Southampton
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06875128 · EU 2025-521966-91-00
Phase 1/2Taking people
A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9
Where
Leeds, London, Manchester, Newcastle upon Tyne, Sutton
Age
18 years and over
People
245 worldwide
Run by
BioNTech SE
See details and how to joinNCT07186842 · EU 2025-522613-26-00
Phase 3Taking people
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
Where
Birmingham, Dundee, Glasgow, Greater London, Leeds, London
Age
18 years to 99 years
People
620 worldwide
Run by
AstraZeneca
See details and how to joinNCT06467357 · EU 2023-508057-19-00
Phase 3Taking people
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Where
Cambridge, Leeds, London, Manchester
Age
18 years and over
People
1,220 worldwide
Run by
AstraZeneca
See details and how to joinNCT06921785 · EU 2024-518210-81-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
London, Newcastle upon Tyne
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Cambridge, London, Middlesex
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 2Taking people
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
Where
Glasgow, Leeds, London, Oxford
Age
18 years and over
People
226 worldwide
Run by
AstraZeneca
See details and how to joinNCT06219941 · EU 2023-508275-37-00
Phase 3Taking people
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
Where
Birmingham, Glasgow, Greater London, Leeds, London, Manchester
Age
18 years and over
People
1,100 worldwide
Run by
AstraZeneca
See details and how to joinNCT07221253 · EU 2025-523085-24-00
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Cambridge, Dundee, London, Manchester
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
Phase 2Taking people
Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients
Where
London
Age
18 years and over
People
72 worldwide
Run by
UNICANCER
See details and how to joinNCT06529718 · EU 2024-515875-36-00
Phase 2Taking people
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
Where
London, Manchester
Age
8 years and over
People
254 worldwide
Run by
Fore Biotherapeutics
See details and how to joinNCT05503797 · EU 2024-513578-23-00
Phase 1Taking people
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Where
London, Sutton
Age
18 years and over
People
714 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05208762 · EU 2023-506604-18-00
No phaseTaking people
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
Where
Birmingham, Liverpool, Newcastle upon Tyne
Age
18 years and over
People
350 worldwide
Run by
Maastricht University Medical Center
See details and how to joinNCT07717437
No phaseTaking people
Clinical Utility of ctDNA in Detecting Resistance Mechanisms and Delivering Precision Medicine to Cancer Patients
Where
London
Age
18 years and over
People
100
Run by
Royal Marsden NHS Foundation Trust
See details and how to joinNCT07673861