Liver and biliary tract cancer trials in Italy

In Italy 88 Also abroad 1314

88 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
Where
Bologna, Milan, Ravenna, Rome
Age
18 years to 100 years
People
104 worldwide
Run by
CatalYm GmbH
See details and how to joinNCT07219459 · EU 2025-520675-86-00
No phaseTaking people
A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice
Where
Acquaviva Delle Fonti, Bergamo, Fano (PU), Genoa, Lecce, Mestre, Milan, Misterbianco (CT), Modena, Naples, Novara, Palermo, Ravenna, Rome, Sassari, Trento, Verona
Age
18 years and over
People
700 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07284121
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Milan, Reggio Emilia, Rome
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
Phase 1/2Taking people
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Where
Milan, Rome
Age
18 years and over
People
220 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06428409 · EU 2023-508703-21-00
Phase 2Taking people
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Where
Bergamo, Brescia, Ferrara, Florence, Milan, Modena, Pavia, Verona
Age
18 years and over
People
750 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06953089 · EU 2025-523895-22-00
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Milan, Naples, Pisa
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
No phaseTaking people
Observational Study Protocol: LIVER-R
Where
Brescia, Milan, Monserrato, Naples, Pisa, Rome, Rozzano, Turin
Age
18 years to 130 years
People
4,000 worldwide
Run by
AstraZeneca
See details and how to joinNCT06252753
Phase 3Taking people
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Where
Candiolo, Genoa, Milan, Monserrato, Naples, Padova, Pisa, Rome, Rozzano, Udine, Verona
Age
18 years and over
People
286 worldwide
Run by
Jazz Pharmaceuticals
See details and how to joinNCT06282575 · EU 2023-508219-21-00
Phase 1Taking people
A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma
Where
Milan, Rozzano, Verona
Age
18 years and over
People
158 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT06600321 · EU 2024-519499-22-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Candiolo, Milan, Naples, Rome, Rozzano
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 1/2Taking people
A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)
Where
Meldola, Milan, Pisa
Age
18 years and over
People
198 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07291076 · EU 2025-523602-33-00
Phase 2Taking people
Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Breast Cancer w/Liver Dominant Disease
Where
Milan
Age
18 years and over
People
90 worldwide
Run by
Delcath Systems Inc.
See details and how to joinNCT06875128 · EU 2025-521966-91-00
Phase 3Taking people
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
Where
Florence, Milan, Naples, Padova, Rome, Rozzano, Tricase
Age
18 years to 99 years
People
620 worldwide
Run by
AstraZeneca
See details and how to joinNCT06467357 · EU 2023-508057-19-00
Phase 3Taking people
Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma
Where
Bologna, Milan, Palermo, Perugia, Pisa, Roma (RM), Rozzano
Age
18 years and over
People
1,220 worldwide
Run by
AstraZeneca
See details and how to joinNCT06921785 · EU 2024-518210-81-00
Phase 1/2Taking people
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
Where
Ancona, Bologna, Candiolo, Milan, Naples, Rozzano
Age
18 years and over
People
138 worldwide
Run by
Pfizer
See details and how to joinNCT07227012 · EU 2025-523525-17-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Candiolo, Milan, Naples, Rome, Rozzano
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Ancona, Bologna, Florence, Milan, Naples, Ravenna
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
No phaseTaking people
MONTEROSA - Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab in Patients With Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment.
Where
Ancona, Bergamo, Foggia, Meldola, Milan, Modena, Naples, Padova, Palermo, Pisa, Pozzuoli, Roma, Rozzano, Torino, Verona
Age
18 years to 100 years
People
200
Run by
AstraZeneca
See details and how to joinNCT07607769
Phase 3Taking people
A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)
Where
Castellana Grotte, Milan, Pisa, Rome, Rozzano
Age
18 years and over
People
1,100 worldwide
Run by
AstraZeneca
See details and how to joinNCT07221253 · EU 2025-523085-24-00
Phase 2Taking people
Fecal Microbiota Transplantation to RESCUE patients with unresectable Hcc progressors to first line therapy with AtezolizUmaB and Bevacizumab (RESCUE-HUB)
Where
Bologna
Age
18 years and over
People
15
Run by
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
See details and how to join2023-510504-45-00 · EU 2023-510504-45-00
No phaseTaking people
Microwave Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms
Where
Milan
Age
18 years and over
People
500
Run by
Francesco De Cobelli
See details and how to joinNCT03981497
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Milan, Naples
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
No phaseNot yet taking people in Italy
Patients With Cryptogenic Hypertransaminasemia
Where
Roma
Age
18 years and over
People
30
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07834125
Phase 2Taking people
Precision Medicine in Patients With Unresectable CholAngiocarcinoma: RadioEmbolization and Combined Biological Therapy
Where
Bergamo, Milan, Naples, Pisa
Age
18 years to 80 years
People
33
Run by
Francesco De Cobelli
See details and how to joinNCT06375915 · EU 2024-516498-57-00
No phaseTaking people
Organoid Models of Hepatocellular Carcinoma
Where
Roma
Age
18 years and over
People
150
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT06929845