Lung cancer: open trials in Ireland

26 open trials have a site in Ireland. Registry data; only the trial team decides who can take part.

NCT06284317
A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.
Trial Treatment · Phase 3 · ETOP IBCSG Partners Foundation
St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9
Registry updated 2026-11-06
NCT06881784
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Trial Treatment · Phase 3 · Revolution Medicines, Inc.
Cork University Hospital, Cork · Tallaght University Hospital, Dublin 24 · St Vincent's University Hospital, Dublin 4 · Mater Private Hospital, Dublin 7 · Beaumont Hospital, Dublin 9 · University Hospital Galway, Galway · University Hospital Limerick, Limerick
Registry updated 2026-11-06
NCT06793215
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Trial Treatment · Phase 3 · Hoffmann-La Roche
Beaumont Hospital, Dublin · Mater Misecordiae University Hospital, Dublin · Tallaght Hospital, Dublin · St James Hospital, Dublin
Registry updated 2026-11-05
NCT07361497
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
Trial Treatment · Phase 3 · Bristol-Myers Squibb
Mater Private Hospital, Dublin 7 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9
Registry updated 2026-11-05
NCT07492680
A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
Trial Treatment · Phase 2 · Bristol-Myers Squibb
Cork University Hospital, Cork · Mater Misericordiae University Hospital (MMUH), Dublin · Dublin
Registry updated 2026-11-04
NCT04613596
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Trial Treatment · Phase 2/3 · Mirati Therapeutics Inc.
Tallaght University Hospital, Dublin 24 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9 · University Hospital Galway, Galway · University Hospital Waterford, Waterford
Registry updated 2026-10-30
NCT06623422
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
Cork University Hospital, Cork · Tallaght University Hospital, Dublin 24 · St James's Hospital, Dublin 8
Registry updated 2026-10-30
NCT05098132
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
Trial Treatment · Phase 1/2 · Synthekine
Mater Misericordiae University Hospital, Dublin 7 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9 · Galway University Hospital, Galway
Registry updated 2026-10-29
NCT06422143
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC
St James's Hospital, Dublin 8
Registry updated 2026-10-29
NCT06931717
A Clinical Study to Assess the Efficacy of Adjuvant Immunotherapy With Cemiplimab in Patients With Surgically Removed Non-small Cell Lung Cancer Who Have Not Received Prior Chemotherapy
Trial Treatment · Phase 3 · ETOP IBCSG Partners Foundation
Cork University Hospital, Cork · St Vincent's University Hospital, Dublin 4 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9
Registry updated 2026-10-28
NCT07109726
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Trial Treatment · Phase 1/2 · Terremoto Biosciences Inc.
START Dublin, Mater Misericordiae University Hospital, Dublin
Registry updated 2026-10-28
NCT07158489
Overcoming Resistance to Immunotherapy Combining Gemcitabine With Ivonescimab in Advanced NSCLC
Trial Treatment · Phase 2 · Swiss Cancer Institute
Tallaght University Hospital, Dublin 24 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9 · University Hospital Galway, Galway
Registry updated 2026-10-28
NCT07472517
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy
Trial Treatment · Phase 3 · Boehringer Ingelheim
Cork University Hospital, Cork
Registry updated 2026-10-28
NCT06875310
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Trial Treatment · Phase 3 · Mirati Therapeutics Inc.
Cork University Hospital, Cork · Beacon Hospital, Dublin 18 · Mater Private Hospital, Dublin 7 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9
Registry updated 2026-10-27
NCT06561386
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
Trial Treatment · Phase 3 · Bristol-Myers Squibb
Beacon Hospital, Dublin 18 · Tallaght University Hospital, Dublin 24 · St James's Hospital, Dublin 8
Registry updated 2026-10-23
NCT05061550
Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
Trial Treatment · Phase 2 · AstraZeneca
Mater Misericordiae University Hospital, Dublin 7 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9 · University Hospital Galway, Galway
Registry updated 2026-10-21
NCT07099898
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC) [EMBOLD SCLC-301]
Trial Treatment · Phase 3 · GlaxoSmithKline
Dublin
Registry updated 2026-10-20
NCT07777614
OPTIMISE Lung SABR
Trial Treatment · Phase 2 · Cancer Trials Ireland
St Luke's Radiation Oncology Network (SLRON) at St Luke's Hospital and St James's Hospital, Dublin
Registry updated 2026-10-16
NCT07541170
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
Trial Treatment · Phase 3 · Hoffmann-La Roche
Cork University Hospital, Cork · St James's Hospital, Dublin 8 · University Hospital Galway, Galway
Registry updated 2026-10-13
NCT07489066
Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in Early-stage or Locally Advanced NSCLC
Trial Treatment · Phase 2 · Pfizer
St James's Hospital, Dublin 8
Registry updated 2026-10-08
NCT06784193
Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 1 · Olema Pharmaceuticals, Inc.
START Dublin, Dublin
Registry updated 2026-10-05
NCT07164313
A Study of ZW251 in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1 · Zymeworks BC Inc.
START - Dublin Mater Misericordiae University Hospital (MMUH), Dublin
Registry updated 2026-10-05
NCT06868277
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
Trial Treatment · Phase 3 · AstraZeneca
Cork University Hospital, Cork · Tallaght University Hospital, Dublin 24 · St Vincent's University Hospital, Dublin 4 · Mater Private Hospital, Dublin 7 · St James's Hospital, Dublin 8 · Beaumont Hospital, Dublin 9 · National University Of Ireland, Galway
Registry updated 2026-09-25
NCT06253871
A Phase 1/1b Study of IAM1363 in HER2 Cancers
Trial Treatment · Phase 1 · Iambic Therapeutics, Inc
Cork University Hospital, Wilton, Cork · St Vincent's University Hospital, Dublin · The START center Dublin, Dublin
Registry updated 2026-09-09
NCT07099027
The Lung Health Check Pilot
Trial Treatment · Royal College of Surgeons, Ireland
Beaumont RCSI Cancer Centre, Dublin
Registry updated 2025-08-01

All Lung cancer trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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