Lung cancer trials in Italy

In Italy 272 Also abroad 2746

272 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 3Not yet taking people in Italy
Effect of Trilaciclib in the Prevention of Myelosupression in Subjects With Limited-stage Small Cell Lung Cancer
Where
Bologna, Ferrara, Orbassano, Siena, Verona
Age
18 years and over
People
120 worldwide
Run by
Pharmacosmos A/S
See details and how to joinNCT07473128 · EU 2025-525026-35-00
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Ancona, Bologna, Florence, Milan, Naples, Ravenna
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 2Taking people
A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)
Where
Avellino, Bologna, Florence, Meldola, Rozzano, Siena, Verona
Age
18 years and over
People
243 worldwide
Run by
Shanghai Henlius Biotech
See details and how to joinNCT06907615 · EU 2025-523803-31-00
Phase 1/2Taking people
A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)
Where
Florence, Meldola, Milan
Age
18 years and over
People
140 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07286149 · EU 2024-512248-47-00
No phaseNot yet taking people in Italy
AI-Assisted 3D Reconstruction for Lung Resection Planning
Where
Rome
Age
18 years and over
People
50
Run by
S. Andrea Hospital
See details and how to joinNCT07853157
Phase 3Taking people
Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC
Where
Ancona, Bari, Candiolo, Meldola, Milan, Monza, Padova, Pisa, Ravenna, Rome, Rozzano, Statte
Age
18 years and over
People
450 worldwide
Run by
Nuvalent Inc.
See details and how to joinNCT06765109 · EU 2024-517553-26-00
Phase 3Taking people
A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer
Where
Ancona, Candiolo, Lecco, Lucca, Meldola, Milan, Naples, Peschiera del Garda, Pisa, Rome, Udine, Verona
Age
18 years and over
People
830 worldwide
Run by
AstraZeneca
See details and how to joinNCT06868277 · EU 2024-517780-24-00
Phase 1/2Taking people
A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)
Where
Ancona, Bari, Milan, Padova, Ravenna, Rome
Age
12 years and over
People
359 worldwide
Run by
Nuvalent Inc.
See details and how to joinNCT05118789 · EU 2024-511793-71-00
Phase 2Taking people
A randomized, run-in, phase II study of nivolumab combined with ipilimumab and oral decitabine/cedazuridine (ASTX727) or nivolumab combined with ipilimumab in melanoma and NSCLC patients resistant to anti-PD-1/PD-L1
Where
Siena
Age
18 years and over
People
148
Run by
Fondazione NIBIT Onlus
See details and how to join2024-518891-29-00
Phase 1/2Taking people
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Where
Aviano, Candiolo, Florence, Milan, Roma
Age
18 years and over
People
416 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06618287
Phase 3Taking people
A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer
Where
Bari, Bergamo, Meldola, Milan, Rome
Age
18 years and over
People
531 worldwide
Run by
AbbVie
See details and how to joinNCT07365241 · EU 2025-523819-11-00
Phase 1Taking people
A study of Daraxonrasib (RMC-6236) in combination with pembrolizumab in participants with nonsmall cell lung cancer with certain mutations -Subprotocol B
Where
Meldola, Milan, Orbassano, Ravenna, Rome
Age
18 years and over
People
180 worldwide
Run by
Revolution Medicines Inc.
See details and how to join2023-509572-42-00
Phase 1/2Taking people
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Where
Ancona, Aviano, Meldola, Milan, Naples, Orbassano, Ravenna, Verona
Age
18 years and over
People
534 worldwide
Run by
Revolution Medicines, Inc.
See details and how to joinNCT06128551
Phase 1Not yet taking people in Italy
Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors
Where
Milan, Naples
Age
18 years to 100 years
People
116 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07006727 · EU 2024-519111-34-00
Phase 1Taking people
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
Where
Candiolo, Rozzano
Age
18 years and over
People
540 worldwide
Run by
SystImmune Inc.
See details and how to joinNCT05983432
Phase 2Taking people
A Trial of Tarlatamab in Patients With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC) and ECOG PS 2
Where
Meldola, Perugia, Rome
Age
18 years and over
People
48 worldwide
Run by
ETOP IBCSG Partners Foundation
See details and how to joinNCT07203053 · EU 2025-522288-13-00
Phase 2Taking people
Neoadjuvant chemo-immunotherapy for stage III PD-L1 positive Non-Small Cell Lung Cancer (NSCLC)
Where
Milan, Rome
Age
18 years and over
People
30
Run by
Fondazione Ricerca Traslazionale
See details and how to join2024-519205-35-01
Phase 3Taking people
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Where
Aviano, Bari, Bergamo, Mantova, Milan, Orbassano, Parma, Peschiera del Garda, Rome, Siena
Age
18 years and over
People
780 worldwide
Run by
Summit Therapeutics
See details and how to joinNCT06767514 · EU 2024-518629-14-00
Phase 2Taking people
A Study of Navlimetostat (BMS-986504) Alone or in Combination With Izalontamab Brengitecan in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion or MTAP Loss (MountainTAP-9)
Where
Bologna, Milan, Monza, Naples, Padova
Age
18 years and over
People
182 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06855771 · EU 2024-519814-29-00
Phase 1/2Taking people
A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors
Where
Candiolo, Meldola, Ravenna
Age
18 years and over
People
118 worldwide
Run by
MediLink Therapeutics (Suzhou) Co., Ltd.
See details and how to joinNCT07407933
Phase 1/2Taking people
A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors
Where
Naples, Padova, Roma, Rozzano
Age
18 years and over
People
630 worldwide
Run by
BeOne Medicines
See details and how to joinNCT06427941 · EU 2025-524136-19-00
Phase 2Not yet taking people in Italy
Hyperprogression upon cemiplimab alone or with chemotherapy in PD-L1 ≥ 50% NSCLC: a biomarker guided phase 2 trial – HYPERBOLIC study
Where
Bergamo, Bologna, Brescia, Crema (CR), Cremona, Genoa, Mantova, Meldola, Milan, Monza, Padova, Parma, Pavia, Peschiera del Garda, Piacenza, Ravenna, Rome, Rozzano, Treviglio, Verona, IRCCS Istituti Fisioterapici Ospitalieri- Istituto Nazionale tumori Regina Elena
Age
18 years and over
People
700
Run by
Universita' Vita-salute S. Raffaele
See details and how to join2025-521583-35-00
Phase 3Taking people
Phase 3 Trial of Tarlatamab (SC vs IV) In Extensive-Stage Small Cell Lung Cancer After Platinum based First-line Chemotherapy (DeLLphi-315)
Where
Bari, Candiolo, Milan, Rome, Verona
Age
18 years and over
People
168 worldwide
Run by
Amgen Inc.
See details and how to join2026-525489-23-00
No phaseTaking people
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
Where
Meldola, Reggio Emilia, Roma
Age
18 years and over
People
2,285 worldwide
Run by
Guardant Health, Inc.
See details and how to joinNCT05059444
No phaseTaking people
Lung cAncer Robotic Comparative Study
Where
Pisa
Age
18 years and over
People
600 worldwide
Run by
Intuitive Surgical
See details and how to joinNCT06038227