Melanoma trials in Italy
62 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 Nov 2026. Ask the study team whether a trial fits you.
Phase 1/2RecruitingTrial-stage medicine
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
- Where
- Rome
- Age
- 6 months to 17 years
- People
- 370 worldwide
- Run by
- Merck Sharp & Dohme LLC
See details and how to joinNCT02332668EU 2022-501257-36-00Registry updated 2026-07-06
Phase 3RecruitingTrial-stage medicine
Adjuvant Tebentafusp in High Risk Ocular Melanoma
- Where
- Milan, Naples, Rome
- Age
- 18 years and over
- People
- 290 worldwide
- Run by
- European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT06246149EU 2023-510333-28-00Registry updated 2026-06-30
No phaseRecruitingResearch participation
The Multicentre Selective Lymphadenectomy Trial - 3
- Where
- Perugia
- Age
- 18 years and over
- People
- 1,500 worldwide
- Run by
- Melanoma Institute Australia
See details and how to joinNCT07049276Registry updated 2026-06-29
Phase 3RecruitingResearch participation
Randomised, Multicentre, Multinational, Double-Blind Integrated Study to Compare the Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB11 (Proposed Nivolumab Biosimilar) Versus EU-/US-Opdivo in Subjects With Previously Untreated Advanced (Unresectable or Metastatic) Melanoma (LEON Study)
- Where
- Catanzaro, Siena
- Age
- 18 years and over
- People
- 119 worldwide
- Run by
- Mabxience Research S.L.
See details and how to join2025-521562-95-00EU 2025-521562-95-00Registry updated 2026-06-04
Phase 3RecruitingTrial-stage medicine
Neoadjuvant Darovasertib in Primary Uveal Melanoma
- Where
- Florence, Milan, Naples, Pisa, Rome
- Age
- 18 years and over
- People
- 520 worldwide
- Run by
- IDEAYA Biosciences
See details and how to joinNCT07015190EU 2025-522387-32-00Registry updated 2026-05-06
Phase 1/2RecruitingTrial-stage medicine
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
- Where
- Milan, Naples, Rome, Verona
- Age
- 18 years and over
- People
- 240 worldwide
- Run by
- Regeneron Pharmaceuticals
See details and how to joinNCT06413680EU 2025-523399-22-00Registry updated 2026-04-28
Phase 3RecruitingTrial-stage medicine
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
- Where
- Naples, Padova, Perugia, Roma, Rome, Siena
- Age
- 18 years and over
- People
- 180 worldwide
- Run by
- ETOP IBCSG Partners Foundation
See details and how to joinNCT05522660Registry updated 2026-04-27
Phase 1RecruitingResearch participation
A Double-Blind, Randomized, Three-arm, Active-Controlled, Parallel-Group, Phase 1 Study Evaluating Pharmacokinetic Similarity of Three Formulations of Pembrolizumab (CT-P51, EU-approved Keytruda, and US-licensed Keytruda) as Adjuvant Therapy in Patients with Completely Resected Stage IIB, IIC, and III Melanoma
- Where
- Meldola, Siena
- Age
- 18 years and over
- People
- 83 worldwide
- Run by
- Celltrion Inc.
See details and how to join2023-510017-26-00EU 2023-510017-26-00Registry updated 2026-04-20
No phaseRecruitingResearch participation
Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any Histotype
- Where
- Padova
- Age
- 18 years to 99 years
- People
- 24
- Run by
- Istituto Oncologico Veneto IRCCS
See details and how to joinNCT06753136Registry updated 2026-04-13
Phase 2/3RecruitingTrial-stage medicine
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
- Where
- Milan, Naples, Rome
- Age
- 18 years and over
- People
- 280 worldwide
- Run by
- Replimune, Inc.
See details and how to joinNCT06581406EU 2023-508784-68-00Registry updated 2026-04-02
No phaseRecruitingResearch participation
A Study of Biological, Genetic, and Constitutional Factors and Non-invasive Monitoring to Assess Personal Cancer Risks
- Where
- Candiolo
- Age
- 18 years and over
- People
- 850
- Run by
- Fondazione del Piemonte per l'Oncologia
See details and how to joinNCT07469709Registry updated 2026-03-13
Phase 3RecruitingTrial-stage medicine
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
- Where
- Milan, Naples, Perugia, Rome, Siena
- Age
- 18 years and over
- People
- 540 worldwide
- Run by
- Immunocore Ltd
See details and how to joinNCT05549297EU 2022-502732-39-00Registry updated 2026-02-25
Phase 3RecruitingTrial-stage medicine
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
- Where
- Bari, Bergamo, Meldola, Milan, Modena, Naples, Padova, Perugia, Ponderano, Roma, Siena, Torino
- Age
- 18 years and over
- People
- 680 worldwide
- Run by
- Immunocore Ltd
See details and how to joinNCT06112314Registry updated 2026-02-25
No phaseRecruitingTrial-stage medicine
INTEGRATIVE "MULTI-OMICS" AND FUNCTIONAL PLATFORM FOR THE COMPLETE DIAGNOSTIC CHARACTERIZATION OF TUMORS: THE ITALIAN TUMOR CHEMOGENOMIC PROFILER (IT-TCP)
- Where
- Palermo, Perugia
- Age
- 1 year and over
- People
- 300
- Run by
- Azienda Ospedaliero-Universitaria di Parma
See details and how to joinNCT07403630Registry updated 2026-02-17
No phaseRecruitingResearch participation
Characteristics of Adult Patients With Melanoma Diagnosis <40 Years Age.
- Where
- Genoa
- Age
- 18 years to 39 years
- People
- 25
- Run by
- Ente Ospedaliero Ospedali Galliera
See details and how to joinNCT06994208Registry updated 2025-12-19
No phaseRecruitingResearch participation
Melanoma of the Skin and Exposure to Solar Ultraviolet Radiation at Work in Modena Territory: a Case-control Study to Promote an Active Search and Prevention of Occupational Diseases Based on Recent INAIL Criteria
- Where
- Modena
- Age
- 18 years and over
- People
- 300
- Run by
- University of Modena and Reggio Emilia
See details and how to joinNCT07251335Registry updated 2025-12-18
Phase 3RecruitingTrial-stage medicine
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
- Where
- Milan, Naples, Perugia, Rome, Rozzano, Siena
- Age
- 18 years and over
- People
- 186 worldwide
- Run by
- Philogen S.p.A.
See details and how to joinNCT03567889EU 2023-507119-36-00Registry updated 2025-12-17
No phaseRecruitingResearch participation
Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions
- Where
- Modena
- Age
- 18 years and over
- People
- 200
- Run by
- University of Modena and Reggio Emilia
See details and how to joinNCT07277920Registry updated 2025-12-11
No phaseNot yet recruitingResearch participation
Neutrophil Biomarker Test for Predicting Clinical Benefit From Immunotherapy Based on Flow Cytometry Analysis
- Where
- Milan
- Age
- 18 years and over
- People
- 600 worldwide
- Run by
- OncoHost Ltd.
See details and how to joinNCT07246759Registry updated 2025-11-24
No phaseRecruitingResearch participation
Study to Evaluate Impact® as Support to Anti PD1 or Anti PD1 Based Regimen Treatment in Patients With Inoperable Locally Advanced or Metastatic Melanoma
- Where
- Naples
- Age
- 18 years and over
- People
- 20
- Run by
- Fondazione Melanoma Onlus
See details and how to joinNCT06880198Registry updated 2025-09-17
No phaseRecruitingResearch participation
MELAFERT: Impact of Adjuvant Therapy on FERTility in Patients With Resected MELAnoma at High Risk of Relapse.
- Where
- Bari, Genova, Milan, Modena, Naples, Padova, Perugia, Roma, Siena, Torino
- Age
- Up to 40 years
- People
- 270
- Run by
- Intergruppo Melanoma Italiano
See details and how to joinNCT07092670Registry updated 2025-09-05
Phase 2RecruitingResearch participation
Hepatic radiotherapy added to standard of care for the treatment of HLA A*02:01 positive Metastatic Uveal Melanoma patients
- Where
- Rome
- Age
- 18 years and over
- People
- 20
- Run by
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to join2024-519760-40-00EU 2024-519760-40-00Registry updated 2025-07-21
No phaseRecruitingResearch participation
An International Study on Pediatric Patients With Rare Tumors.
- Where
- Padova
- Age
- 0 years to 18 years
- People
- 6,250
- Run by
- Azienda Ospedaliera di Padova
See details and how to joinNCT07072143Registry updated 2025-07-18
No phaseRecruitingTrial-stage medicine
Anti PD-1 Plus Postbiotic Versus Anti PD-1 Alone in Locally Advanced or Metastatic, Treatment naïve, Cutaneous Melanoma Study
- Where
- Bari, Milan, Perugia, Torino
- Age
- 18 years and over
- People
- 35
- Run by
- Azienda Ospedaliera di Perugia
See details and how to joinNCT07050940Registry updated 2025-07-03
No phaseRecruitingResearch participation
Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
- Where
- Milan
- Age
- 18 years to 90 years
- People
- 1,000
- Run by
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
See details and how to joinNCT05621837Registry updated 2025-05-02
All Melanoma trials and the map
This page is not medical advice. Talk to your doctor before contacting a trial.