Melanoma trials in Spain

In Spain 50 Also abroad 578

50 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Phase II study of Roginolisib in UM patients
Where
L'Hospitalet de Llobregat, Madrid, Santiago de Compostela, Sevilla, Valencia
Age
18 years and over
People
43 worldwide
Run by
iOnctura SA
See details and how to join2024-514333-37-00 · EU 2024-514333-37-00
Phase 3Taking people
VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
Where
Barcelona, Madrid, Murcia, Pamplona
Age
12 years and over
People
400 worldwide
Run by
Replimune, Inc.
See details and how to joinNCT06264180 · EU 2023-508612-29-00
Phase 3Taking people
Adjuvant Tebentafusp in High Risk Ocular Melanoma
Where
L'Hospitalet de Llobregat, Madrid, Valladolid
Age
18 years and over
People
290 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT06246149 · EU 2023-510333-28-00
Phase 3Taking people
Randomised, Multicentre, Multinational, Double-Blind Integrated Study to Compare the Pharmacokinetics, Efficacy, Safety, and Immunogenicity of MB11 (Proposed Nivolumab Biosimilar) Versus EU-/US-Opdivo in Subjects With Previously Untreated Advanced (Unresectable or Metastatic) Melanoma (LEON Study)
Where
Barcelona, Bilbao, Huelva, Lleida, Madrid, Málaga, Sabadell, Sevilla, Torrejón de Ardoz
Age
18 years and over
People
119 worldwide
Run by
Mabxience Research S.L.
See details and how to join2025-521562-95-00 · EU 2025-521562-95-00
Phase 3Taking people
Neoadjuvant Darovasertib in Primary Uveal Melanoma
Where
L'hospitalet De Llobregat, Pamplona, Santiago de Compostela, Sevilla, Valladolid
Age
18 years and over
People
520 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07015190 · EU 2025-522387-32-00
Phase 1/2Taking people
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
Where
Barcelona, Madrid, Sevilla, Valencia
Age
18 years and over
People
240 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06413680 · EU 2025-523399-22-00
Phase 3Taking people
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
Where
Barcelona, Majadahonda, Valencia
Age
18 years and over
People
180 worldwide
Run by
ETOP IBCSG Partners Foundation
See details and how to joinNCT05522660
Phase 1Taking people
A Double-Blind, Randomized, Three-arm, Active-Controlled, Parallel-Group, Phase 1 Study Evaluating Pharmacokinetic Similarity of Three Formulations of Pembrolizumab (CT-P51, EU-approved Keytruda, and US-licensed Keytruda) as Adjuvant Therapy in Patients with Completely Resected Stage IIB, IIC, and III Melanoma
Where
Badalona, Barcelona, Cáceres, Madrid, Málaga, Sabadell, Santander, Torrejón de Ardoz
Age
18 years and over
People
83 worldwide
Run by
Celltrion Inc.
See details and how to join2023-510017-26-00 · EU 2023-510017-26-00
Phase 2/3Taking people
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
Where
L'Hospitalet de Llobregat
Age
18 years and over
People
280 worldwide
Run by
Replimune, Inc.
See details and how to joinNCT06581406 · EU 2023-508784-68-00
Phase 3Taking people
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
Where
Barcelona, Madrid, Málaga, Valencia
Age
18 years and over
People
540 worldwide
Run by
Immunocore Ltd
See details and how to joinNCT05549297 · EU 2022-502732-39-00
Phase 3Taking people
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
Where
A Coruña, Barcelona, Córdoba, El Palmar, Granada, Las Palmas de Gran Canaria, Madrid, Málaga, Pamplona, Reus, San Sebastián, Santander, Seville, Valencia, Zaragoza
Age
18 years and over
People
680 worldwide
Run by
Immunocore Ltd
See details and how to joinNCT06112314
Phase 1Taking people
A Study to Evaluate the Pharmacokinetics, Efficacy, Safety and Immunogenicity of Xdivane versus Opdivo® in Patients with Resected Melanoma
Where
Badajoz, Barcelona, Cáceres, Madrid, Málaga
Age
18 years and over
People
34 worldwide
Run by
Intas Pharmaceuticals Limited
See details and how to join2025-522307-14-00 · EU 2025-522307-14-00
Phase 4Taking people
A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3
Where
Barcelona, Madrid, Valencia
Age
18 years and over
People
50 worldwide
Run by
Replimune, Inc.
See details and how to joinNCT06887348 · EU 2025-521621-33-00
Phase 3Taking people
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients
Where
Badalona, Barcelona, Donostia, Las Palmas De Gran Canaria, Madrid, Málaga, Murcia, Sevilla, Valencia
Age
18 years and over
People
186 worldwide
Run by
Philogen S.p.A.
See details and how to joinNCT03567889 · EU 2023-507119-36-00
No phaseNot yet taking people in Spain
Neutrophil Biomarker Test for Predicting Clinical Benefit From Immunotherapy Based on Flow Cytometry Analysis
Where
Seville
Age
18 years and over
People
600 worldwide
Run by
OncoHost Ltd.
See details and how to joinNCT07246759
Phase 2Taking people
Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases
Where
A Coruña, Almería, Barcelona, Burgos, Cáceres, Donostia, L'Hospitalet de Llobregat, Madrid, Majadahonda, Málaga, Murcia, Santander, Sevilla, Toledo, Valencia, Valladolid
Age
18 years and over
People
33
Run by
Grupo Español Multidisciplinar de Melanoma
See details and how to joinNCT06887088 · EU 2024-513375-40-00
No phaseTaking people
Resistance Exercise in Patients With Ocular Melanoma
Where
Valencia
Age
18 years and over
People
40
Run by
University of Valencia
See details and how to joinNCT06970236
No phaseTaking people
Precision Medicine for L/GCMN and Melanoma 1
Where
Barcelona
People
6,000
Run by
Fundacion Clinic per a la Recerca Biomédica
See details and how to joinNCT06608420
No phaseTaking people
Understanding the Transition from Normal Melanocytes to Nevus to Melanoma
Where
Barcelona
People
100 worldwide
Run by
Fundacion Clinic per a la Recerca Biomédica
See details and how to joinNCT06605417
No phaseTaking people
Precision Medicine for L/GCMN and Melanoma 2
Where
Barcelona
Age
18 years and over
People
100
Run by
Fundacion Clinic per a la Recerca Biomédica
See details and how to joinNCT06605443
Phase 2Taking people
Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer (PragmaTIL)
Where
Barcelona
Age
18 years and over
People
40
Run by
Vall d'Hebron Institute of Oncology
See details and how to joinNCT06630611
No phaseTaking people
The 4D PICTURE Project: Evaluating Metro Mapping As a Method to Support Shared Decision Making in Oncology
Where
Zaragoza
Age
18 years and over
People
500 worldwide
Run by
Leiden University Medical Center
See details and how to joinNCT06685562
No phaseTaking people
Artificial Intelligence Based Melanoma Early Diagnosis and Risk Prediction in Children, Adolescents and Young Adults
Where
Barcelona
People
3,000 worldwide
Run by
German Cancer Research Center
See details and how to joinNCT06621810
Phase 2Taking people
Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors
Where
Barcelona, Madrid, Valencia
Age
18 years and over
People
60 worldwide
Run by
IO Biotech
See details and how to joinNCT05280314
No phaseTaking people
Spanish Academy of Dermatology and Venereology (AEDV) Melanoma Registry
Where
A Coruña, Badalona, Barcelona, Córdoba, Las Palmas, León, Madrid, Oviedo, Palma de Mallorca, Pontevedra, Santa Cruz de Tenerife, Seville, Valencia, Zaragoza
People
7,000
Run by
Fundación Academia Española de Dermatología
See details and how to joinNCT05673681