Mesothelioma: open trials in United States

54 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT01950572
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Research · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-11-05
NCT04847063
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Trial Treatment · Phase 1 · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-11-05
NCT06885697
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
Trial Treatment · Phase 1 · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-11-05
NCT07563738
A 2-part Phase 1/2 Open-label Trial on ODM-212
Trial Treatment · Phase 1/2 · Orion Corporation, Orion Pharma
NEXT Oncology- Virginia, Fairfax · START Dallas Fort Worth, Fort Worth · NEXT Oncology, Irving · Valkyrie Clinical Trials, Los Angeles · UC Irvine Health, Orange
Registry updated 2026-11-05
NCT03556228
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Trial Treatment · Phase 1/2 · VM Oncology, LLC
Presbyterian Kaseman Hospital (site 208), Albuquerque · Englewood Hospital and Medical Center (site 202), Englewood · Summit Medical Group (site 205), Florham Park · Holy Cross Hospital (site 213), Fort Lauderdale · Hartford Hospital (site 210), Hartford · The University of Texas MD Anderson Cancer Center (site 127), Houston · Atlantic Health System, Morristown Medical Center (site 124), Morristown · Weill Cornell Medicine, Cornell University (site 126), New York · Memorial Cancer Institute at Memorial Healthcare Systems (site 132), Pembroke Pines · Providence Medical Foundation (site 209), Santa Rosa · The George Washington University Cancer Center (site 212), Washington D.C. · Cancer Care Associates of York (site 206), York
Registry updated 2026-11-04
NCT05579366
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
Trial Treatment · Phase 1/2 · Genmab
USOR Texas Oncology, Abilene · Augusta University, Georgia Cancer Center, Augusta · Texas Oncology - Central/South Texas, Austin · Massachusetts General Hospital, Boston · Dana-Farber Cancer Institute, Boston · MD Anderson Cancer Center at Cooper- Two Cooper Plaza, Camden · Ohio State University Comprehensive Cancer Center (OSUCCC)- The James Cancer Hospital and Solove Research Institute, Columbus · Mary Crowley Cancer Research, Dallas · Karmanos Cancer Institute, Detroit · USOR Alliance Cancer Specialist, Doylestown · USOR - Oncology Associates of Oregon, P.C, Eugene · Swedish Cancer Institute, Everett · USOR Virginia Cancer Specialists, Fairfax · USOR Florida Cancer Specialists South, Fort Myers · USOR Texas Oncology, Fort Worth · START | Midwest, Grand Rapids · University of California Los Angeles Medical Center, Los Angeles · USOR Minnesota Oncology Hematology, Maplewood · Tennessee Oncology, Nashville · Sarah Cannon Research Institute at Tennessee Oncology, Nashville · USOR Virginia Oncology Associates, Norfolk · University of Oklahoma Health Sciences Center, Oklahoma City · USOR HonorHealth, Phoenix · Allegheny Health Network, Pittsburgh · Compass Oncology - Rose Quarter, Portland · Women and Infants Hospital of Rhode Island, Providence · USOR Maryland Oncology Hematology, Rockville · University of California San Diego Moores Cancer Center, San Diego · USOR Sansum Clinic, Santa Barbara · Providence Medical Foundation, Santa Rosa · USOR Florida Cancer Specialists North, St. Petersburg · USOR Arizona Oncology Associates, Tucson · Texas Oncology - Northeast TX, Tyler · USOR Florida Cancer Specialists East, West Palm Beach · START Mountain Region, West Valley City · University of Kansas Medical Center (KUMC), Westwood · USOR Texas Oncology Gulf Coast, Woodland
Registry updated 2026-11-04
NCT06251310
SW-682 in Advanced Solid Tumors
Trial Treatment · Phase 1 · SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
University Hospital of Cleveland, Cleveland · Mary Crowley Research Center US Oncology, Dallas · U.T. MD Anderson Cancer Center, Houston · USC Norris Comprehensive Cancer Center and Hospital, Los Angeles · Oregon Health and Science University, Knight Cancer Institute - Marquam Hill, Portland · UC San Diego Moores Cancer Center, Sacramento · UCLA Hematology-Oncology - Santa Monica, Santa Monica · HonorHealth Research Institute, Scottsdale
Registry updated 2026-10-30
NCT04431024
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome
Research · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-29
NCT06503146
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
Trial Treatment · Phase 2 · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-29
NCT06710756
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Trial Treatment · Phase 1/2 · Perspective Therapeutics
Cleveland Clinic, Cleveland · Ohio State University, Columbus · UT Southwestern University Hospital Radiology Clinic, Dallas · MD Anderson Cancer Center, Houston · University of Kansas, Kansas City · University of Kentucky, Lexington · VA Greater Los Angeles Healthcare System, Los Angeles · UCLA Department of Medicine - Hematology/Oncology, Los Angeles · University of Wisconsin, Madison · Biogenix, Miami · University of Miami, Miami · Memorial Sloan Kettering Cancer Center - Main Campus, New York · Nebraska Cancer Specialists, Omaha · University of Pittsburgh Medical Center, Pittsburgh · Mayo Clinic in Rochester, Minnesota, Rochester · Saint Louis University, St Louis
Registry updated 2026-10-28
NCT04981119
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
Research · A2 Biotherapeutics Inc.
Massachusetts General Hospital/Dana Farber Cancer Institute, Boston · The Ohio State University Comprehensive Cancer Center, Columbus · City of Hope, Duarte · Banner Health, Gilbert · MD Anderson Cancer Center, Houston · Mayo Clinic- Jacksonville, Jacksonville · University of California San Diego, La Jolla · Vanderbilt University Medical Center, Nashville · NYU Langone Medical Center, New York · Stanford University, Palo Alto · Mayo Clinic Hospital, Phoenix · Mayo Clinic - Rochester, Rochester · UCLA Medical Center, Santa Monica · Fred Hutchinson Cancer Center, Seattle · Washington University, St Louis · Moffitt Cancer Center, Tampa
Registry updated 2026-10-26
NCT05001880
Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma
Trial Treatment · Phase 2 · National Cancer Institute (NCI)
ThedaCare Regional Cancer Center, Appleton · Sanford Joe Lueken Cancer Center, Bemidji · Sanford Bismarck Medical Center, Bismarck · Alliance for Clinical Trials in Oncology, Chicago · University of Chicago Comprehensive Cancer Center, Chicago · Ohio State University Comprehensive Cancer Center, Columbus · UT MD Anderson - The Woodlands, Conroe · Mercy Hospital, Coon Rapids · Carle at The Riverfront, Danville · Marshfield Medical Center-EC Cancer Center, Eau Claire · Minnesota Oncology - Edina, Edina · Fairview Southdale Hospital, Edina · Carle Physician Group-Effingham, Effingham · Sanford Broadway Medical Center, Fargo · Sanford Roger Maris Cancer Center, Fargo · Unity Hospital, Fridley · UT MD Anderson Cancer Center, Houston · UT MD Anderson - West Houston, Houston · UT MD Anderson - League City, League City · University of Kentucky/Markey Cancer Center, Lexington · Marshfield Medical Center-Marshfield, Marshfield · Carle Physician Group-Mattoon/Charleston, Mattoon · Abbott-Northwestern Hospital, Minneapolis · Marshfield Medical Center - Minocqua, Minocqua · University of Oklahoma Health Sciences Center, Oklahoma City · Mayo Clinic Hospital in Arizona, Phoenix · UPMC Hillman Cancer Center, Pittsburgh · Marshfield Medical Center-Rice Lake, Rice Lake · Mayo Clinic in Rochester, Rochester · Park Nicollet Clinic - Saint Louis Park, Saint Louis Park · United Hospital, Saint Paul · Regions Hospital, Saint Paul · Sanford USD Medical Center - Sioux Falls, Sioux Falls · Sanford Cancer Center Oncology Clinic, Sioux Falls · Marshfield Medical Center-River Region at Stevens Point, Stevens Point · UT MD Anderson - Sugar Land, Sugar Land · The Carle Foundation Hospital, Urbana · Carle Cancer Center, Urbana · Marshfield Medical Center - Weston, Weston · Rice Memorial Hospital, Willmar · Sanford Cancer Center Worthington, Worthington
Registry updated 2026-10-26
NCT07705334
A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 1 · SHY Therapeutics
The University of Texas MD Anderson Cancer Center, Houston · NEXT Oncology, San Antonio · HonorHealth Research Institute, Scottsdale
Registry updated 2026-10-22
NCT03830229
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1
Research · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-16
NCT04792463
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome
Research · Mohamed Abdel-Rahman
The Ohio State University -Wexner Medical Center, Columbus
Registry updated 2026-10-16
NCT05960773
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma
Trial Treatment · Phase 2 · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-16
NCT00242723
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Research · National Cancer Institute (NCI)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-15
NCT06239194
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
Trial Treatment · Phase 1/2 · ModeX Therapeutics, An OPKO Health Company
Massachusetts General Hospital, Boston · Sarah Cannon Research Institute, Denver · MD Anderson Cancer Center, Houston · Sylvester Comprehensive Cancer Center - University of Miami Health System, Miami · Sarah Cannon Research Institute, Nashville · NEXT Oncology, San Antonio
Registry updated 2026-10-15
NCT06623396
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer or Malignant Peritoneal Mesothelioma
Trial Treatment · Phase 1 · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge · Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities), Commack · Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison · Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale
Registry updated 2026-10-15
NCT05932199
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Trial Treatment · Phase 1/2 · Baylor College of Medicine
Duke Cancer Institute, Durham · Baylor St Lukes, Houston
Registry updated 2026-10-02
NCT07277413
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
Trial Treatment · Phase 1 · IDEAYA Biosciences
BRCR Global - Coral Springs, Coral Springs · City of Hope Cancer Center-Duarte, Duarte · START Astera, LLC, East Brunswick · NEXT Oncology- Virginia, Fairfax · START Dallas Fort Worth, Fort Worth · City of Hope Cancer Center Phoenix, Goodyear · Next Oncology - Houston, Houston · MD Anderson, Houston · Next Oncology Dallas, Irving · Mayo Clinic Florida, Jacksonville · Sarah Cannon Research Institute, Nashville · Columbia University Irving Medical Center, New York · Nebraska Cancer Specialists, Omaha · Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando · Sidney Kimmel Comprehensive Cancer Center Thomas Jefferson University, Philadelphia · Mayo Clinic - Arizona, Phoenix · Mayo Clinic - Rochester, Rochester · Providence Medical Foundation, Santa Rosa · Swedish Cancer Institute, Seattle · Moffitt Cancer Center, Tampa · Johns Hopkins Sibley Memorial Hospital, Washington D.C. · START Mountain Region, LLC, West Valley City · City of Hope® Cancer Center Chicago, Zion
Registry updated 2026-09-28
NCT06037941
Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma
Trial Treatment · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Basking Ridge (Consent Only), Basking Ridge · Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent only), Commack · Memorial Sloan Kettering Westchester (Consent only), Harrison · Memorial Sloan Kettering Monmouth (Consent Only), Middletown · Memorial Sloan Kettering Bergen (Consent Only), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (Consent Only), Uniondale
Registry updated 2026-09-24
NCT06057935
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
Trial Treatment · Phase 2 · Memorial Sloan Kettering Cancer Center
University of Michigan (Data Collection Only), Ann Arbor · Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge · University of Chicago (Data Collection Only), Chicago · Memorial Sloan Kettering Commack (Limited protocol activities), Commack · Memorial Sloan Kettering Westchester (Limited Protocol Activites), Harrison · Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale · Rutgers University (Data Collection Only), New Brunswick · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · University of Nebraska (Data collection only), Omaha · ALLEGHENY HEALTH NETWORK (Data Collection Only), Pittsburgh · Washington University (Data Collection Only), St Louis · Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale
Registry updated 2026-09-24
NCT06566079
Study of ISM6331 in Participants With Advanced/Metastatic Mesothelioma or Other Advanced Solid Tumors
Trial Treatment · Phase 1/2 · InSilico Medicine Hong Kong Limited
NEXT Oncology - Austin, Austin · The University of Chicago Medical Center - Duchossois Center for Advanced Medicine, Chicago · University Hospitals Cleveland Medical Center*, Cleveland · Sarah Cannon Research Institute at HealthONE, Denver · SCRI Oncology Partners, Nashville · University of Pennsylvania/Abramson Cancer Center, Philadelphia
Registry updated 2026-09-16
NCT07532902
A Study of BMS-986504 With Standard-of-Care Therapy for People With Solid Tumor Cancer
Trial Treatment · Phase 1 · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Basking Ridge (All Protocol Activities), Basking Ridge · Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities), Commack · Memorial Sloan Kettering Westchester (All Protocol Activities), Harrison · Memorial Sloan Kettering Monmouth (All Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (All Protocol Activities), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale
Registry updated 2026-09-16

All Mesothelioma trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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