Metastatic breast cancer trials in United States

In United States 223 Also abroad 610

223 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
Where
Boston, Grand Rapids, Houston, Los Angeles, Nashville, New Haven, Newton, Trumbull
Age
18 years and over
People
430 worldwide
Run by
Pfizer
See details and how to joinNCT04557449 · EU 2024-512120-11-00
No phaseTaking people
Screening For BCRL In Targeted Therapy For Breast Cancer
Where
Boston
Age
18 years to 80 years
People
261
Run by
Massachusetts General Hospital
See details and how to joinNCT05142800
No phaseTaking people
The COMPASSION Study
Where
Boston
Age
18 years and over
People
200
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT06507930
Phase 1/2Taking people
A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
Where
Athens, Atlanta, Basking Ridge, Beverly Hills, Chicago, Dallas, Detroit, Florham Park, Grand Rapids, Harrison, Kansas City, Madison, Middletown, Montvale, Nashville, Newport Beach, New York, Port Saint Lucie, San Antonio, St Louis, Stony Brook, Uniondale
Age
18 years and over
People
380 worldwide
Run by
BioNTech SE
See details and how to joinNCT06827236 · EU 2024-517979-20-00
Phase 1Taking people
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Where
Austin, Celebration, Denver, Detroit, Duarte, East Brunswick, Fairfax, Fort Worth, Houston, Irvine, Irving, Lake Success, Nashville, New Haven, New York, Plantation, San Antonio, Sarasota, Spokane, West Valley City
Age
18 years and over
People
150 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07503808 · EU 2026-526299-21-00
No phaseTaking people
Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain Metastases
Where
Bethesda
Age
18 years to 120 years
People
139
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07619534
No phaseTaking people
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Where
Aberdeen, Adrian, ‘Aiea, Albuquerque, Allentown, Alton, American Fork, Ames, Anaconda, Anaheim, Anchorage, Ann Arbor, Antigo, Arroyo Grande, Atlanta, Auburn, Aurora, Aventura, Baker City, Baldwin Park, Ballwin, Bardstown, Battle Creek, Beavercreek, Bellevue, Bellflower, Bellingham, Belpre, Bemidji, Bend, Bethlehem, Billings, Bismarck, Bloomington, Bluffton, Boardman, Boiling Springs, Boise, Bolivar, Bonne Terre, Boone, Boulder, Bozeman, Branson, Bremerton, Brighton, Bryan, Burbank, Burien, Burlington, Burnsville, Burr Ridge, Butte, Caldwell, Cambridge, Cameron Park, Canton, Cape Girardeau, Cape May Court House, Carbondale, Carmichael, Caro, Carson City, Carterville, Carthage, Cedar City, Centennial, Centerville, Centralia, Chattanooga, Chelsea, Chesapeake, Chesterfield, Cheyenne, Chillicothe, Chippewa Falls, Cincinnati, Clackamas, Clarkston, Cleveland, Clinton, Clive, Cody, Coeur d'Alene, Collierville, Colorado Springs, Columbia, Columbus, Concord, Cookeville, Coon Rapids, Cooperstown, Coos Bay, Corbin, Council Bluffs, Creston, Danville, Dayton, Decatur, Deerfield Beach, Delaware, Denver, Derby, Des Moines, Detroit, Dixon, Doylestown, Dublin, Durango, Easley, East China, Easton, East Stroudsburg, Eau Claire, Edina, Edmonds, Effingham, Egg Harbor, Elk Grove, Elmira, Emeryville, Emmett, Englewood, Enumclaw, Escanaba, Eureka, Everett, ‘Ewa Beach, Fairbanks, Fairfield, Fargo, Farmington, Federal Way, Findlay, Flint, Fontana, Fort Dodge, Fort Lauderdale, Fort Smith, Franklin, Fridley, Fruitland, Galesburg, Garden City, Gastonia, Gig Harbor, Glastonbury, Golden, Goldsboro, Grand Forks, Grand Island, Grand Junction, Grand Rapids, Great Bend, Great Falls, Greeley, Green Bay, Greenville, Greenwich, Greer, Grenada, Grosse Pointe Woods, Grove City, Guilford, Gulfport, Harrisburg, Hartford, Hastings, Hays, Hazleton, Helena, Henderson, Hilton Head Island, Hixson, Homer Glen, Honolulu, Hot Springs, Independence, Indianapolis, Irvine, Issaquah, Jacksonville, Janesville, Jefferson, Jefferson City, Jonesboro, Joplin, Kahului, Kailua, Kalamazoo, Kalispell, Kansas City, Kearney, Kennewick, Kettering, Kewanee, Kingman, Lacey, La Crosse, Ladysmith, Lafayette, Lakeland, Lakewood, Lancaster, Lansing, Las Cruces, Las Vegas, Lawrence, Lenexa, Lewisburg, Lexington, Lihue, Lima, Lincoln, Little Rock, Littleton, Livonia, Logan, London, Lone Tree, Longmont, Longview, Los Angeles, Louisville, Loveland, Macomb, Manchester, Mansfield, Maple Grove, Maplewood, Marietta, Marion, Marlette, Marrero, Marshalltown, Marshfield, Martinez, Martinsville, Mattoon, Maumee, Mayfield Heights, Maywood, Medford, Melrose Park, Memphis, Meridian, Miami Beach, Minneapolis, Minocqua, Missoula, Moline, Monroe, Monticello, Mooresville, Morristown, Mount Sterling, Mount Vernon, Muncie, Murray, Muskegon, Nags Head, Nampa, Napa, New Albany, Newark, Newberg, New Haven, New Orleans, Newport Beach, New Richmond, New Ulm, New York, Niles, North Haven, Norton Shores, Oakland, Oconto Falls, O'Fallon, Ogden, Oklahoma City, Olathe, Omaha, Ontario, Ooltewah, Orange, Oregon City, Ottawa, Overland Park, Oxford, Paducah, Pahrump, Palm Springs, Panorama City, Papillion, Parker, Pasadena, Pascagoula, Peabody, Pekin, Pensacola, Peoria, Perrysburg, Peru, Philadelphia, Phoenix, Phoenixville, Pittsburg, Pittsburgh, Pontiac, Portland, Portsmouth, Port Townsend, Post Falls, Pottstown, Pottsville, Poulsbo, Princeton, Provo, Pueblo, Puyallup, Rapid City, Redmond, Reed City, Reno, Renton, Rice Lake, Richmond, Rio Rancho, River Forest, Riverside, Riverton, Robbinsdale, Rochester, Rochester Hills, Rocklin, Rolla, Sacramento, Saginaw, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Salem, Salina, Salt Lake City, San Diego, Sandpoint, Sandusky, San Luis Obispo, San Marcos, Santa Maria, Santa Rosa, Savannah, Scranton, Seattle, Sedro-Woolley, Selinsgrove, Seneca, Sewell, Shakopee, Sheboygan, Shelton, Shepherdsville, Sheridan, Shreveport, Silver Spring, Sioux Falls, Southhaven, Spokane, Spokane Valley, Springfield, Stamford, State College, Sterling Heights, Stevens Point, St. George, Stillwater, St Louis, Stockton, Strongsville, Sturgeon Bay, Sullivan, Summit, Sunset Hills, Swansea, Tacoma, Tawas City, The Bronx, Thief River Falls, Thornton, Toledo, Topeka, Torrington, Traverse City, Troy, Trumbull, Tucson, Twin Falls, Urbana, Vancouver, Waconia, Walla Walla, Walnut Creek, Warren, Warrensville Heights, Washington, Waterbury, Waterford, Waterloo, Wausau, West Branch, West Des Moines, Westerly, Westerville, Weston, Wheat Ridge, Wichita, Wilkes-Barre, Williamsport, Willmar, Winchester, Wisconsin Rapids, Woodbury, Woodland, Woodland Hills, Wooster, Worthington, Wyoming, Yakima, Yelm, Yorkville, Youngstown, Ypsilanti, Zanesville
Age
18 years and over
People
739 worldwide
Run by
SWOG Cancer Research Network
See details and how to joinNCT03723928
Phase 1Taking people
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Where
Bethesda, Fairway
Age
12 years to 120 years
People
116
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04222413
Phase 2Taking people
Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer
Where
Duarte, Irvine
Age
18 years and over
People
18
Run by
City of Hope Medical Center
See details and how to joinNCT06260033
Phase 2Taking people
ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
Where
Ann Arbor, Billings, Canton, Dallas, Denver, Duarte, Durham, Fairfax, Golden, Grand Junction, Houston, Jacksonville, La Jolla, Miami, New York, Omaha, Orange, Phoenix, Portland, Rochester, Saint Louis Park, Seattle, St Louis, Tampa, Tucson, Washington D.C., Zion
Age
18 years and over
People
120 worldwide
Run by
ALX Oncology Inc.
See details and how to joinNCT07007559
No phaseTaking people
Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer
Where
Duarte
Age
18 years and over
People
160
Run by
City of Hope Medical Center
See details and how to joinNCT07664579
No phaseNot yet taking people in United States
Transcranial Direct Current Stimulation to Improve Gait for Breast Cancer Survivor's Who Received Taxene and/or Platinum Chemotherapy
Where
Ann Arbor
Age
60 years to 85 years
People
60
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07864792
Phase 1Taking people
A Phase 1/1b Study of PRT13722 in Participants With Advanced HR+/HER2- Breast Cancer
Where
Maumee
Age
18 years and over
People
242
Run by
Prelude Therapeutics Incorporated
See details and how to joinNCT07905001 · EU 2026-527825-37-00
Phase 1/2Taking people
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
Where
Chattanooga, Columbus, Duarte, Durham, Germantown, Hackensack, Howell Township, Irvine, La Jolla, Longmont, Los Angeles, Nashville, New Brunswick, New York, Omaha, Philadelphia, Pittsburgh, Plano, Reno, Saint Paul, Stanford, Tampa, Zion
Age
18 years and over
People
1,132 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT03424005 · EU 2023-503629-20-00
Phase 2Taking people
Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort
Where
Birmingham, Dallas, Memphis, Nashville
Age
18 years and over
People
64
Run by
Sonya Reid
See details and how to joinNCT05693766
No phaseTaking people
Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)
Where
Houston, Philadelphia, San Diego, San Francisco
Age
18 years and over
People
150
Run by
University of California, San Francisco
See details and how to joinNCT05964504
Phase 2Taking people
Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer
Where
Aurora, Aventura, Baltimore, City of Saint Peters, Clemmons, Columbus, Coral Gables, Creve Coeur, Deerfield Beach, Galveston, Hartford, Lebanon, Miami, New Haven, New York, Oklahoma City, Orange, Pittsburgh, Plantation, Richmond, Sacramento, St Louis, Tampa, Wesley Chapel, Winston-Salem
Age
18 years and over
People
86
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03606967
Phase 1/2Taking people
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Where
Ann Arbor, Boston, Cerritos, Fairfax, Hershey, Houston, Indianapolis, Iowa City, Lakeland, Los Angeles, Memphis, Nashville, New Haven, New York, Orange, San Diego, Seattle, Shirley, Sioux Falls, Skokie, Tampa
Age
18 years and over
People
910 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06324357
Phase 3Taking people
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
Where
Altamonte Springs, Ann Arbor, Atlanta, Austin, Baltimore, Beverly Hills, Boston, Chicago, Dallas, Duarte, Fairfax, Fort Myers, Gilbert, Hackensack, Houston, Indianapolis, Jackson, Knoxville, Longmont, Los Angeles, Madison, Minneapolis, Nashville, Newark, New Brunswick, New Haven, New York, Norfolk, Omaha, Palm Bay, Palo Alto, Portland, Reno, Royal Oak, Sacramento, Salt Lake City, San Diego, San Francisco, Sioux Falls, St Louis, Temple, Vallejo, Washington D.C., Westwood, Wichita
Age
18 years and over
People
540 worldwide
Run by
Relay Therapeutics, Inc.
See details and how to joinNCT06982521 · EU 2025-523083-21-00
Phase 1Taking people
A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
Where
Conroe, Duarte, Grand Rapids, Houston, League City, Long Island City, New York, San Antonio, Sugar Land, West Valley City
Age
18 years and over
People
260 worldwide
Run by
Pfizer
See details and how to joinNCT07318805 · EU 2025-524387-38-00
Phase 2/3Taking people
RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive
Where
Albany, Austin, Clovis, East Brunswick, Fort Worth, Germantown, Gilbert, Grand Rapids, Huntsville, Nashville, Norwich, Sacramento, San Francisco, Shirley, Stony Brook, The Bronx
Age
18 years and over
People
650 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07413939 · EU 2025-524498-17-00
No phaseNot yet taking people in United States
Prospective Study to Evaluate the Clinical Utility of ctDNA Tumor Fraction (TF) for Detection of Estrogen Receptor 1 (ESR1) Mutations in (Human Epidermal Growth Factor Receptor) HR+/HER2- Metastatic Breast Cancer (MBC)
Where
New Haven
Age
18 years and over
People
155
Run by
Yale University
See details and how to joinNCT07910565
No phaseTaking people
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Where
Aberdeen, Aitkin, Akron, Albert Lea, Albuquerque, Allentown, Alma, Alpena, Alton, Amarillo, Ames, Anaconda, Anchorage, Anderson, Ankeny, Ann Arbor, Antigo, Appleton, Arroyo Grande, Asheville, Ashland, Augusta, Aurora, Aventura, Baker City, Bakersfield, Ballwin, Baltimore, Baraboo, Barberton, Bardstown, Barrington, Baton Rouge, Battle Creek, Baxter, Beavercreek, Belfast, Bellingham, Belpre, Bemidji, Bend, Berlin, Bethesda, Bethlehem, Biddeford, Billings, Bismarck, Bloomington, Boardman, Boise, Bolivar, Bonita Springs, Boone, Boulder, Bozeman, Brainerd, Branson, Braselton, Brewer, Brighton, Brownstown, Brunswick, Bryan, Burbank, Burien, Burlington, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Carbondale, Carmichael, Caro, Carson City, Carterville, Carthage, Cary, Cedar Rapids, Centennial, Centerville, Centralia, Chaska, Chelsea, Chesapeake, Chesterfield, Cheyenne, Chicago, Chillicothe, Cincinnati, Clackamas, Clarkston, Clearwater, Clinton, Clinton Township, Clive, Clyde, Cody, Coeur d'Alene, Colorado Springs, Columbia, Columbus, Concord, Coon Rapids, Coos Bay, Corbin, Council Bluffs, Creston, Crosslake, Crystal Lake, Cudahy, Danville, Dayton, Dearborn, Decatur, Deerfield Beach, Deer River, Delaware, Denver, Des Moines, Detroit, Detroit Lakes, Dixon, Downers Grove, Dublin, Duluth, Durango, Durham, East China Township, Easton, East Stroudsburg, Eau Claire, Edgewood, Edina, Edmonds, Effingham, Elgin, Elk Grove, Elmhurst, Elmira, Ely, Emeryville, Emmett, Englewood, Enumclaw, Eureka, Everett, Evergreen Park, Fairbanks, Fargo, Farmington, Farmington Hills, Federal Way, Findlay, Fishersville, Flint, Florence, Fond du Lac, Fort Collins, Fort Dodge, Fort Lauderdale, Fort Myers, Fort Smith, Fort Thomas, Fosston, Franklin, Freehold, Fridley, Fruitland, Gaffney, Gahanna, Gainesville, Galesburg, Garden City, Garner, Georgetown, Germantown, Gladwin, Glen Burnie, Glens Falls, Goldsboro, Grafton, Grand Forks, Grand Island, Grand Rapids, Great Bend, Great Falls, Greeley, Green Bay, Greenville, Greenwood, Greer, Grosse Pointe Woods, Grove City, Hackettstown, Harvey, Havre, Hayward, Hazel Crest, Hazleton, Helena, Henderson, Hendersonville, Hibbing, Hood River, Houma, Houston, Huntington, International Falls, Issaquah, Jackson, Jacksonville, Jamaica, Jamaica Plain, Jamestown, Janesville, Jefferson, Jefferson City, Joplin, Kalamazoo, Kalispell, Kansas City, Kearney, Kennewick, Kenosha, Kettering, Kewanee, Kingman, Lacey, La Crosse, Lakeland, Lakewood, Lancaster, Lansing, Laredo, Las Cruces, Las Vegas, Leavenworth, Lewisburg, Lexington, Libertyville, Lima, Lincoln, Little Rock, Littleton, Livonia, Loma Linda, London, Lone Tree, Long Beach, Longmont, Longview, Loveland, Macomb, Madison, Manchester, Mankato, Mansfield, Maple Grove, Maplewood, Marietta, Marinette, Marion, Marlette, Marrero, Marshalltown, Martinez, Marysville, Mattoon, Meadowbrook, Mechanicsville, Medford, Medina, Merced, Meridian, Metairie, Miami Beach, Midland, Midlothian, Milwaukee, Minneapolis, Minot, Missoula, Moline, Monticello, Moose Lake, Morristown, Mount Pleasant, Mount Sterling, Mount Vernon, Mukwonago, Mullica Hill, Murrells Inlet, Muskegon, Nags Head, Nampa, Napa, Neenah, New Albany, Newark, Newberg, New Brunswick, New London, New Orleans, New Richmond, Newton, New Ulm, New York, Niles, Norfolk, Normal, Norton Shores, Novi, Oakland, Oak Lawn, Ocean Pines, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Olney, Omaha, Ontario, Oregon City, Osage Beach, Oshkosh, Ottawa, Paducah, Pahrump, Papillion, Parker, Park Rapids, Park Ridge, Pekin, Pennington, Peoria, Pequot Lakes, Perrysburg, Peru, Phoenix, Phoenixville, Pine River, Pittsburg, Plant City, Pompton, Pontiac, Portland, Portsmouth, Port Townsend, Post Falls, Pottstown, Princeton, Providence, Pueblo, Racine, Raleigh, Rancho Mirage, Randallstown, Reading, Redmond, Reed City, Reno, Renton, Rhinelander, Richmond, Rio Rancho, Robbinsdale, Rockford, Rocklin, Rockport, Rolla, Royal Oak, Sacramento, Safety Harbor, Saginaw, Saint Cloud, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Salisbury, San Antonio, Sandpoint, Sandstone, Sanford, San Luis Obispo, Santa Cruz, Santa Maria, Santa Rosa, Savannah, Scarborough, Seattle, Sedro-Woolley, Shakopee, Shawano, Sheboygan, Shelton, Sheridan, Silverdale, Sioux Falls, Southfield, South Portland, Spartanburg, Spokane, Spooner, Springfield, Staples, Sterling Heights, Stevens Point, St. Helena, Stillwater, St Louis, Stockton, Stony Brook, St. Petersburg, Sturgeon Bay, Sullivan, Summit, Superior, Tacoma, Tampa, Tawas City, Thief River Falls, Thornton, Tifton, Toledo, Topeka, Towson, Traverse City, Troy, Twin Falls, Two Rivers, Union, Urbana, Vancouver, Vineland, Virginia, Virginia Beach, Waconia, Walla Walla, Walnut Creek, Warren, Warwick, Washington, Washington D.C., Waukee, Waukesha, Waupaca, Wausau, Wauwatosa, Weaverville, West Allis, West Bloomfield, West Branch, West Columbia, West Des Moines, Westerville, West Haven, Westminster, West Reading, Wichita, Wilkes-Barre, Willmar, Wilmington, Winter Haven, Wisconsin Rapids, Woodbury, Woodland, Worthington, Wyandotte, Wyoming, Yakima, Yelm, Yorkville, Youngstown, Ypsilanti, Zanesville
Age
40 years to 75 years
People
2,900
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT05334069
Phase 3Taking people
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
Where
Annapolis, Baltimore, Burbank, Charlotte, Cleveland, Detroit, Durham, East Brunswick, Edmonds, Everett, Florham Park, Fort Worth, Germantown, Goodyear, Grand Island, Grand Rapids, Greenville, Irvine, Jacksonville, Kansas City, La Jolla, Lexington, Long Beach, Los Alamitos, Los Angeles, Louisville, Marietta, Mayfield Heights, Minneapolis, Nashville, New York, O'Fallon, Omaha, Palo Alto, Phoenix, Pittsburgh, Portland, Salt Lake City, San Marcos, San Mateo, Seattle, Shirley, Spring, Springfield, Sunnyvale, Tacoma, Tallahassee, Tampa, The Bronx, Urbana, Weston, Winston-Salem, Zion
Age
18 years and over
People
450 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06790693 · EU 2024-516162-11-00
Phase 1Taking people
Clinical Trial of Avasopasem in Patients With Metastatic Hormone Receptor Positive Breast Cancer With Progression on a CDK 4/6 Inhibitor and Hormonal Therapy
Where
San Antonio
Age
18 years and over
People
35
Run by
The University of Texas Health Science Center at San Antonio
See details and how to joinNCT07137871