Multiple sclerosis: open trials in Spain

36 open trials have a site in Spain. Registry data; only the trial team decides who can take part.

NCT07067463
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Trial Treatment · Phase 3 · Zenas BioPharma (USA), LLC
Complexo Hospitalario Universitario A Coruña, A Coruña · Hospital Germans Trias i Pujol, Badalona · Hospital Universitario de Cruces, Barakaldo · Hospital Nisa Sevilla Aljarafe, Castilleja De La Cuesta · Hospital Universitario 12 de Octubre, Madrid · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Santa Caterina Ias, Salt · Hospital Alvaro Cunqueiro, Vigo
Registry updated 2026-11-03
2023-504358-36-00
Efficacy and safety study of frexalimab (SAR441344) in adults with relapsing forms of multiple sclerosis
Trial Treatment · Phase 3 · Sanofi-Aventis Recherche & Developpement
Hospital Universitari Vall d'Hebron, Barcelona · Hospital Universitario Reina Sofia, Córdoba · El Hospital Universitario De Gran Canaria Dr. Negrin, Las Palmas De Gran Canaria · Hospital Universitario de la Princesa, Madrid · Hospital Universitario Ramón y Cajal, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Regional de Málaga, Málaga · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Clínico Universitario de Valladolid, Valladolid
Registry updated 2026-10-28
NCT07299019
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Trial Treatment · Phase 3 · Zenas BioPharma (USA), LLC
Complexo Hospitalario Universitario A Coruña, A Coruña · Hospital Germans Trias i Pujol, Badalona · Hospital Universitario de Cruces, Barakaldo · Hospital del Mar, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Clinic de Barcelona, Barcelona · Hospital Nisa Sevilla Aljarafe, Castilleja De La Cuesta · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario 12 de Octubre, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · Hospital Vithas Parque San Antonio, Malaga · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Santa Caterina Ias, Salt · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Alvaro Cunqueiro, Vigo
Registry updated 2026-10-27
NCT06846281
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Hospital Universitari Vall d'Hebron, Barcelona · Hospital Universitario Reina Sofia, Córdoba · Hospital Clínico San Carlos, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital Universitario Ramón y Cajal, Madrid · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda · Hospital Universitario Regional de Málaga, Málaga · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Santa Caterina Ias, Salt · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Universitario Dr. Peset Aleixandre, Valencia
Registry updated 2026-10-26
2024-519304-28-00
Non-inferiority study of frexalimab subcutaneous administration compared to intravenous administration in adult participants with multiple sclerosis.
Trial Treatment · Phase 3 · Sanofi-Aventis Recherche & Developpement
Hospital Universitari Vall d'Hebron, Barcelona · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Universitario Regional de Málaga, Málaga · Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón · Hospital Alvaro Cunqueiro, Vigo
Registry updated 2026-10-23
NCT07310862
Virtual Reality - Gamma Sensory Stimulation for Improving Fatigue in People With Multiple Sclerosis
Trial Treatment · Clarity Health Technologies, Inc
Hospital del Mar, Barcelona
Registry updated 2026-10-22
2024-512914-16-00
A Randomized, Double-blind, Study to Demonstrate Pharmacokinetic Similarity, and Evaluate Safety, Immunogenicity, Pharmacodynamics and Clinical Effects between ABP 692 and Ocrevus® (Ocrelizumab) in Subjects with Relapsing-remitting Multiple Sclerosis
Trial Treatment · Phase 3 · Amgen Inc.
Hospital Universitario Fundación Alcorcón, Alcorcón · Hospital Clinic de Barcelona, Barcelona · Hospital Nisa Sevilla Aljarafe, Castilleja De La Cuesta · Hospital De Denia, Denia · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Vithas Parque San Antonio, Malaga · Hospital Universitario Regional de Málaga, Málaga · Hospital Santa Caterina Ias, Salt · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Universitario Dr. Peset Aleixandre, Valencia · Hospital Alvaro Cunqueiro, Vigo
Registry updated 2026-10-20
NCT07139743
Obe-cel in Refractory Progressive Forms of Multiple Sclerosis
Trial Treatment · Phase 1 · Autolus Limited
Hospital Universitari Vall d'Hebron, Barcelona · Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-10-16
NCT07161258
A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)
Trial Treatment · Phase 2 · Hoffmann-La Roche
Hospital Universitario Ramón y Cajal, Madrid · Hospital Universitario de la Princesa, Madrid · Hospital Universitario Virgen Macarena, Seville
Registry updated 2026-10-13
NCT07225504
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
Novartis Investigative Site, Albacete · Novartis Investigative Site, Alicante · Novartis Investigative Site, Barakaldo · Novartis Investigative Site, Barcelona · Novartis Investigative Site, Castilleja de la Cuesta · Novartis Investigative Site, El Palmar · Novartis Investigative Site, Jerez de la Frontera · Novartis Investigative Site, Las Palmas GC · Novartis Investigative Site, L'Hospitalet de Llobregat · Novartis Investigative Site, Lleida · Novartis Investigative Site, Logroño · Novartis Investigative Site, Madrid · Novartis Investigative Site, Málaga · Novartis Investigative Site, Pozuelo de Alarcón · Novartis Investigative Site, Salamanca · Novartis Investigative Site, Seville · Novartis Investigative Site, Torrejón de Ardoz · Novartis Investigative Site, Valencia
Registry updated 2026-10-13
NCT07325292
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Trial Treatment · Phase 3 · Sanofi
Investigational Site Number : 7240010, Barcelona · Investigational Site Number : 7240023, Madrid · Investigational Site Number : 7240005, Málaga · Investigational Site Number : 7240001, Pozuelo de Alarcón · Investigational Site Number : 7240014, Vigo
Registry updated 2026-10-13
NCT07282574
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Trial Treatment · Phase 2 · Hoffmann-La Roche
Hospital General Universitario de Albacete, Albacete · Hospital Universitario de Cruces, Barakaldo · Hospital Clinic de Barcelona, Barcelona · Hospital Universitari Vall d'Hebron, Barcelona · Hospital del Mar, Barcelona · Hospital de la Santa Creu i Sant Pau, Barcelona · Bellvitge University Hospital, L'hospitalet De Llobregat · Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida, Lleida · Hospital Universitario Ramón y Cajal, Madrid · Hospital Universitario de la Princesa, Madrid · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario Regional de Málaga, Málaga · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón · Hospital Santa Caterina Ias, Salt · Hospital Universitario Marqués de Valdecilla, Santander · Complexo Hospitalario Universitario De Santiago, Santiago de Compostela · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Clinico Universitario de Valencia, Valencia · Complexo Hospitalario Universitario De Vigo, Vigo
Registry updated 2026-10-07
NCT07847853
Inductive Therapeutic Exercise in Multiple Sclerosis
Trial Treatment · Fundación San Juan De Dios
Escuela Universitaria de Enfermería y Fisioterapia San Juan de Dios - Universidad Pontificia Comillas, Madrid · Hospital Universitario San Rafael, Madrid
Registry updated 2026-10-02
2024-511686-11-00
Efficacy and safety of ofatumumab and siponimod compared to fingolimod in pediatric patients with multiple sclerosis
Trial Treatment · Phase 3 · Novartis Pharma AG
Hospital Universitario de Cruces, Barakaldo · Hospital Universitario Ramón y Cajal, Madrid · Hospital Universitario Central De Asturias, Oviedo · Hospital Universitario Virgen De La Macarena, Sevilla
Registry updated 2026-09-29
NCT06408259
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Trial Treatment · Phase 3 · Bristol-Myers Squibb
Sant Joan De Deu Barcelona Hospital, Esplugues De Llobregat · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Alvaro Cunqueiro, Vigo · Hospital Unviersitario Miguel Servet, Zaragoza
Registry updated 2026-09-10
NCT07805473
[18F]F-DED PET Imaging of Reactive Astrocytes in Multiple Sclerosis
Trial Treatment · Parc de Salut Mar
Hospital del Mar Research Institute, Barcelona
Registry updated 2026-09-04
2024-512707-40-00
A Phase 2 Study of Obexelimab in Patients with Relapsing Multiple Sclerosis
Trial Treatment · Phase 2 · Zenas Biopharma (USA) LLC
Hospital General Universitario Gregorio Marañón, Madrid · Hospital Clínico San Carlos, Madrid · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Universitario Y Politecnico La Fe, Valencia
Registry updated 2026-08-27
NCT05658497
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Research · Biogen
Hospital Universitario Ramón y Cajal, Madrid
Registry updated 2026-08-11
NCT07168772
The Effect of a Probiotic Administration as an add-on Treatment in Multiple Sclerosis
Trial Treatment · Hospital Universitari Vall d'Hebron Research Institute
Centre d'Esclerosi Mútiple de Catalunya (Cemcat), Barcelona
Registry updated 2026-08-07
NCT07741864
Effectiveness of a Mindfulness-Based Intervention for Pain Management in Patients With Multiple Sclerosis (MPIMS).
Trial Treatment · Hospital Universitario Virgen Macarena
Hopsital Universitario Virgen Macarena, Seville
Registry updated 2026-08-03
NCT07738120
Immersive Virtual Reality and Exercise Programs in Multiple Sclerosis: ExeRVIEM III
Trial Treatment · University of Vigo
University of Vigo, Pontevedra
Registry updated 2026-07-31
2025-521546-23-00
A clinical trial to find out how well LOU064 (remibrutinib) works and how safe it is for people with secondary progressive multiple sclerosis
Trial Treatment · Phase 3 · Novartis Pharma AG
Hospital General Universitario de Albacete, Albacete · Hospital General Universitario Dr. Balmis, Alicante · Hospital Universitario de Cruces, Barakaldo · Hospital Universitari Vall d'Hebron, Barcelona · Hospital Nisa Sevilla Aljarafe, Castilleja De La Cuesta · Hospital de Jerez de la Frontera, Jerez de la Frontera · El Hospital Universitario De Gran Canaria Dr. Negrin, Las Palmas De Gran Canaria · Bellvitge University Hospital, L'hospitalet De Llobregat · Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida, Lleida · Hospital San Pedro, Logroño · Hospital Universitario Ramón y Cajal, Madrid · Hospital Universitario Fundación Jiménez Díaz, Madrid · Hospital General Universitario Gregorio Marañón, Madrid · Hospital Clínico San Carlos, Madrid · Hospital Universitario de la Princesa, Madrid · Hospital Universitario Virgen de la Victoria, Málaga · Hospital Universitario Regional de Málaga, Málaga · University Clinical Hospital Virgen De La Arrixaca, Murcia · Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón · Hospital Universitario De Salamanca, Salamanca · Hospital Universitario Virgen De La Macarena, Sevilla · Hospital Universitario de Torrejon, Torrejón de Ardoz · Hospital Universitario Y Politecnico La Fe, Valencia · Hospital Universitario Dr. Peset Aleixandre, Valencia
Registry updated 2026-07-30
NCT06968676
Mixed Reality for Upper Limb Rehabilitation in People With Multiple Sclerosis (VIRTUALDOMUS)
Trial Treatment · Universidad Rey Juan Carlos
Asociación de Leganés de Esclerosis Múltiple, Leganés
Registry updated 2026-05-05
NCT07020715
A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis
Trial Treatment · Phase 2 · University Hospital, Antwerp
Hospital Germans Trias i Pujol, Badalona
Registry updated 2026-05-05
NCT07567989
Effectiveness of Home-Based Exercise and Brain Stimulation for Reducing Fatigue in Patients With Multiple Sclerosis
Trial Treatment · Jacobo Formigo
Complexo Hospitalario Universitario de A Coruña, A Coruña · Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela · Complexo Hospitalario Universitario De Vigo, Vigo
Registry updated 2026-05-05

All Multiple sclerosis trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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