Multiple sclerosis: open trials in United States

• NCT03109288

  Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

  Trial Treatment · Phase 1/2 · National Institute of Allergy and Infectious Diseases (NIAID)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-20

• NCT04047628

  Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

  Trial Treatment · Phase 3 · National Institute of Allergy and Infectious Diseases (NIAID)

  Rocky Mountain Multiple Sclerosis Center, University of Colorado School of Medicine, Aurora · University of Virginia, Charlottesville · University of Cincinnati (UC) Waddell Center for Multiple Sclerosis, Cincinnati · Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland · University of Texas Southwestern Medical Center: Division of Multiple Sclerosis and Neuroimmunology, Dallas · Henry Ford Neuroscience Institute, Detroit · Duke University Medical Center, Durham · Northwestern University, Evanston · Maxine Mesigner Multiple Sclerosis Comprehensive Care Center, Baylor College of Medicine Medical Center, Houston · Medical College of Wisconsin, Milwaukee · University of Minnesota Multiple Sclerosis Center, Minneapolis · Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Siinai, New York · Stanford Multiple Sclerosis Center, Palo Alto · Penn Comprehensive MS Center, Hospital of the University of Pennsylvania, Philadelphia · Multiple Sclerosis Center, Oregon Health & Science University, Portland · Virginia Commonwealth University Multiple Sclerosis Treatment and Research Center, Richmond · Mayo Clinic, Rochester · Rochester Multiple Sclerosis Center, University of Rochester, Rochester · Multiple Sclerosis Center at Northwest Hospital, Seattle · Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle · Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle · John L. Trotter Multiple Sclerosis Center, Washington University School of Medicine in St. Louis, St Louis · University of Massachusetts Memorial Medical Center, Worcester

  Registry updated 2026-10-20

• NCT05003388

  Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS

  Trial Treatment · Phase 1 · The Foundation for Orthopaedics and Regenerative Medicine

  Prodromos Stem Cell Institute, Naples

  Registry updated 2026-10-20

• NCT07304154

  Study of KITE-363 in Participants With Autoimmune Neurologic Diseases That Did Not Respond to Usual Treatment

  Trial Treatment · Phase 1 · Kite, A Gilead Company

  Hoag Memorial Hospital Presbyterian, Newport Beach · Columbia University Irving Medical Center, New York · Stanford Neuroscience Health Center, Palo Alto · LDS Hospital - Intermountain Health, Salt Lake City · Fred Hutchinson Cancer Center, Seattle

  Registry updated 2026-10-19

• NCT07139743

  Obe-cel in Refractory Progressive Forms of Multiple Sclerosis

  Trial Treatment · Phase 1 · Autolus Limited

  Stanford University, Palo Alto

  Registry updated 2026-10-16

• NCT07878923

  Early Versus Delayed Start of Ocrevus Zunovo for Relapsing Multiple Sclerosis

  Research · Oklahoma Medical Research Foundation

  Oklahoma Medical Research Foundation, Oklahoma City

  Registry updated 2026-10-16

• NCT06434571

  Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection

  Trial Treatment · Phase 2 · University of Kansas Medical Center

  University of Kansas Medical Center- Sleep, Health and Wellness Laboratory, Kansas City

  Registry updated 2026-10-13

• NCT07225504

  A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

  Trial Treatment · Phase 3 · Novartis Pharmaceuticals

  University of New Mexico Hospital, Albuquerque · Neurology of Central FL Res Ctr, Altamonte Springs · UC Health Neuroscience Ctr, Aurora · Mid Atlantic Epilepsy and Sleep Ctr, Bethesda · Alabama Neurology Associates PC, Birmingham · Atrium Health, Charlotte · Northwestern Memorial Hospital, Chicago · Cleveland Clinic Ohio, Cleveland · Neurology Clinic, PC, Cordova · Carum Research, Dallas · Michigan Institute of Neurological, Farmington Hills · Neuro Institute of New England P C, Foxborough · Clinre Comprehensive Neurology, Frederick · Fullerton Neuro and Headache Ctr, Fullerton · UF Health Cancer Center, Gainesville · Premier Neurology, Greenville · Homestead Assoc In Research Inc, Homestead · Hawaii Pacific Neuroscience LLC, Honolulu · University of Kansas Hospital, Kansas City · Neurology Associates PA, Maitland · Miami NS Ins Baptist Health S FL, Miami · Aqualane Clinical Research, Naples · Vanderbilt Breast Center at One Hundred Oaks, Nashville · Hoag Memorial Hospital Presbyterian, Newport Beach · Comprehensive Neurology Clinic, Orlando · Orlando Health Clinical Trials, Orlando · Neurology Associates of Ormond Beach, Ormond Beach · Ctr for Neurology and Spine, Phoenix · AZ Integrated Neuro and Spine, Phoenix · Xenoscience Inc., Phoenix · Saturn Research Solution, Plano · Velocity Clinical Research, Raleigh · University of Washington MS Clinic, Seattle · Joi Life Wellness Group LLC, Smyrna · Citta Clinical Research, Spokane · University of South Florida, Tampa · Axiom Brain Health, Tampa · Center for Neurosciences, Tucson · Medstar Washington Hosp Ctr, Washington D.C. · Georgetown University Hospital, Washington D.C. · Elliot Lewis MS Center, Wellesley · Regina Berkovich MD PhD Inc, West Hollywood · U Mass Memorial Medical Center, Worchester

  Registry updated 2026-10-13

• NCT07325292

  Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

  Trial Treatment · Phase 3 · Sanofi

  Abington · Neurology of Central Florida- Site Number : 8400147, Altamonte Springs · Atlanta Neuroscience Institute- Site Number : 8400075, Atlanta · Rocky Mountain Regional VA Medical Center- Site Number : 8400121, Aurora · Baltimore Veterans Affairs Medical Center- Site Number : 8400163, Baltimore · Piedmont HealthCare - Lake Norman Neurology- Site Number : 8400002, Charlotte · The Boster Center for Multiple Sclerosis- Site Number : 8400006, Columbus · The Ohio State University- Site Number : 8400009, Columbus · North Central Neurology Associates- Site Number : 8401100, Cullman · El Paso · Michigan Institute for Neurological Disorders- Site Number : 8400004, Farmington Hills · Advanced Neurology of Colorado- Site Number : 8400148, Fort Collins · Neurology Center of New England- Site Number : 8400164, Foxborough · Norman Fixel Institute for Neurological Diseases (FIND)- Site Number : 8400054, Gainesville · Homewood · Knoxville · Lancaster · Medical College of Wisconsin - Milwaukee Campus- Site Number : 8400038, Milwaukee · Naples · Northbrook · Orlando Health Neuroscience Institute - Downtown Pavilion- Site Number : 8400060, Orlando · Neurology Associates of Ormond Beach- Site Number : 8400086, Ormond Beach · Center for Neurology and Spine - Phoenix - East Bell Road- Site Number : 8400195, Phoenix · North Texas Institute of Neurology & Headache - Plano- Site Number : 8400082, Plano · North Texas Institute of Neurology & Headache - Plano- Site Number : 8400083, Plano · Raleigh · Neurology Center of San Antonio- Site Number : 8400099, San Antonio · Perseverance Research Center- Site Number : 8400138, Scottsdale · Joi Life Wellness Group LLC- Site Number : 8400192, Smyrna · University of South Florida- Site Number : 8400013, Tampa · Holy Name Medical Center- Site Number : 8400101, Teaneck · Center for Neurosciences - Tucson- Site Number : 8400194, Tucson · Private Practice - Dr. Regina Berkovich- Site Number : 8400005, West Hollywood · West Palm Beach

  Registry updated 2026-10-13

• NCT07825389

  C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Progressive Multiple Sclerosis Refractory to Standard Therapy

  Trial Treatment · Phase 1/2 · AbelZeta Inc.

  Gilbert · La Jolla

  Registry updated 2026-10-13

• NCT00794352

  Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

  Research · National Institute of Allergy and Infectious Diseases (NIAID)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-08

• NCT04699747

  Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

  Trial Treatment · Phase 1 · Massachusetts General Hospital

  Massachusetts General Hospital, Boston

  Registry updated 2026-10-07

• NCT04390009

  Entire-body PET Scans for Multiple Sclerosis

  Trial Treatment · Early phase 1 · Brain Health Alliance

  Brain Health Alliance, Ladera Ranch

  Registry updated 2026-10-06

• NCT07504120

  The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

  Trial Treatment · University of Illinois Chicago

  University of Illinois Chicago, Chicago

  Registry updated 2026-10-06

• NCT02784210

  Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

  Trial Treatment · Phase 2 · National Institute of Neurological Disorders and Stroke (NINDS)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-05

• NCT03816345

  Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

  Trial Treatment · Phase 1 · National Cancer Institute (NCI)

  Emory University Hospital/Winship Cancer Institute, Atlanta · Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore · National Institutes of Health Clinical Center, Bethesda · National Cancer Institute Developmental Therapeutics Clinic, Bethesda · University of Alabama at Birmingham Cancer Center, Birmingham · Massachusetts General Hospital Cancer Center, Boston · Dana-Farber Cancer Institute, Boston · University of Chicago Comprehensive Cancer Center, Chicago · Northwestern University, Chicago · Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters · Ohio State University Comprehensive Cancer Center, Columbus · Siteman Cancer Center at West County Hospital, Creve Coeur · UT Southwestern Simmons Cancer Center - RedBird, Dallas · UT Southwestern/Simmons Cancer Center-Dallas, Dallas · Wayne State University/Karmanos Cancer Institute, Detroit · University of Kansas Clinical Research Center, Fairway · UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth · HaysMed, Hays · UT MD Anderson Cancer Center, Houston · University of Kansas Cancer Center, Kansas City · University Health Truman Medical Center, Kansas City · University of Kansas Cancer Center - North, Kansas City · Lawrence Memorial Hospital, Lawrence · University of Kansas Cancer Center - Lee's Summit, Lee's Summit · University of Kentucky/Markey Cancer Center, Lexington · NYU Langone Hospital - Long Island, Mineola · Rutgers Cancer Institute of New Jersey, New Brunswick · Smilow Cancer Center/Yale-New Haven Hospital, New Haven · Yale University, New Haven · Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York · NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York · NYP/Weill Cornell Medical Center, New York · University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City · The University of Kansas Cancer Center - Olathe, Olathe · University of Kansas Cancer Center-Overland Park, Overland Park · University of Kansas Hospital-Indian Creek Campus, Overland Park · Stanford Cancer Institute Palo Alto, Palo Alto · Thomas Jefferson University Hospital, Philadelphia · Mercy Hospital Pittsburg, Pittsburg · UPMC Hillman Cancer Center, Pittsburgh · UT Southwestern Clinical Center at Richardson/Plano, Richardson · VCU Massey Comprehensive Cancer Center, Richmond · University of California Davis Comprehensive Cancer Center, Sacramento · Salina Regional Health Center, Salina · Huntsman Cancer Institute/University of Utah, Salt Lake City · Washington University School of Medicine, St Louis · Siteman Cancer Center at Christian Hospital, St Louis · Siteman Cancer Center-South County, St Louis · University of Kansas Health System Saint Francis Campus, Topeka · MedStar Georgetown University Hospital, Washington D.C. · University of Kansas Hospital-Westwood Cancer Center, Westwood

  Registry updated 2026-10-05

• NCT06992115

  A Study of the MIND Diet for Persons With Multiple Sclerosis

  Trial Treatment · Icahn School of Medicine at Mount Sinai

  Mount Sinai Hospital, New York

  Registry updated 2026-10-02

• NCT07472413

  Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project

  Trial Treatment · Phase 3 · University of Miami

  UHealth Boca Raton, Boca Raton

  Registry updated 2026-10-02

• NCT05539729

  Vancomycin Study in Multiple Sclerosis (MS)

  Trial Treatment · Phase 1 · Icahn School of Medicine at Mount Sinai

  Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai, New York

  Registry updated 2026-09-28

• NCT07831928

  Evaluation of an Online, On Demand Multimodal Wellness Program to Reduce Fatigue and Improve Quality of Life in Progressive Multiple Sclerosis.

  Trial Treatment · University of Iowa

  UI Health Care, Iowa City

  Registry updated 2026-09-28

• NCT07475377

  Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

  Trial Treatment · University of Alabama at Birmingham

  University of Alabama at Birmingham, Birmingham

  Registry updated 2026-09-25

• NCT07477639

  Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

  Trial Treatment · Phase 1/2 · Tr1X, Inc.

  University of Cincinnati, Cincinnati · Duke University, Durham · University of Kansas Medical Center, Kansas City · UC San Diego, La Jolla · Mt. Sinai, New York · Mayo Clinic, Rochester · Providence Swedish, Seattle · Washington University St. Louis, St Louis

  Registry updated 2026-09-21

• NCT05805839

  A Study of Imaging in Demyelinating Diseases

  Trial Treatment · Phase 2 · Mayo Clinic

  Mayo Clinic Minnesota, Rochester

  Registry updated 2026-09-17

• NCT07606742

  Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis

  Trial Treatment · The University of Texas Health Science Center, Houston

  The University of Texas Health Science Center at Houston, Houston

  Registry updated 2026-09-17

• NCT03135327

  Clinical Applications of Advanced Ophthalmic Imaging

  Trial Treatment · University of Miami

  Bascom Palmer Eye Institute, Miami

  Registry updated 2026-09-16

All Multiple sclerosis trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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