Multiple sclerosis: open trials in United States

184 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT07067463
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Trial Treatment · Phase 3 · Zenas BioPharma (USA), LLC
Nova Clinical Research, LLC, Bradenton · The Ohio State University Wexner Medical Center (OSUWMC), Columbus · The Boster Center for Multiple Sclerosis, Columbus · Neurology Clinic, P.C., Cordova · Premier Neurology, Greenville · University of Kansas Medical Center, Kansas City · Cooperman Barnabas Medical Center, Livingston · Neurology Associates PA, Maitland · Medical College of Wisconsin, Milwaukee · Neurological Services of Orlando, Orlando · Arizona Neuroscience Research, LLC, Pheonix · Velocity Clinical Research, Raleigh Neurology, Raleigh · KC Research Center, PA Neurology Research Department, Roeland Park · Lone Star Neurology, San Antonio · Perseverance Research Center, Scottsdale · Texas Institute for Neurological Disorders - Sherman, Sherman · Washington University School of Medicine, St Louis · University of South Florida Department of Neurology - MS Division, Tampa · Regina Berkovich MD PhD Inc, West Hollywood
Registry updated 2026-11-03
NCT07376772
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
Trial Treatment · University of Florida
Norman Fixel Institute for Neurological Diseases, Gainesville · University of Florida, Gainesville
Registry updated 2026-11-03
NCT07914257
Treatment of Memory Retrieval Impairments in MS With HDtDCS to the LIFG in a Placebo Controlled Trial
Trial Treatment · The University of Texas at Dallas
Callier Clinical Researcher Center, Richardson
Registry updated 2026-11-03
NCT06951919
HOBSCOTCH-MS-Efficacy Trial
Trial Treatment · Dartmouth-Hitchcock Medical Center
Dartmouth-Health Lebanon, Lebanon
Registry updated 2026-11-02
NCT07738978
Understanding and Enhancing Human Health and Movement
Trial Treatment · Louis Stokes VA Medical Center
Louis Stokes Cleveland VA Medical Center, Cleveland
Registry updated 2026-11-02
NCT06433752
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Research · TG Therapeutics, Inc.
TG Therapeutics Investigational Trial Site, Altamonte Springs · TG Therapeutics Investigational Trial Site, Amherst · TG Therapeutics Investigational Trial Site, Ann Arbor · TG Therapeutics Investigational Trial Site, Atlanta · TG Therapeutics Investigational Trial Site, Aurora · TG Therapeutics Investigational Trial Site, Austin · TG Therapeutics Investigational Trial Site, Avon · TG Therapeutics Investigational Trial Site, Baltimore · TG Therapeutics Investigational Trial Site, Basalt · TG Therapeutics Investigational Trial Site, Bethlehem · TG Therapeutics Investigational Trial Site, Billings · TG Therapeutics Investigational Trial Site, Birmingham · TG Therapeutics Investigational Trial Site, Boca Raton · TG Therapeutics Investigational Trial Site, Boston · TG Therapeutics Investigational Trial Site, Bridgewater · TG Therapeutics Investigational Trial Site, Burlington · TG Therapeutics Investigational Trial Site, Centerville · TG Therapeutics Investigational Trial Site, Charlotte · TG Therapeutics Investigational Trial Site, Charlottesville · TG Therapeutics Investigational Trial Site, Cherry Hill · TG Therapeutics Investigational Trial Site, Chicago · TG Therapeutics Investigational Trial Site, Cincinnati · TG Therapeutics Investigational Trial Site, Clearwater · TG Therapeutics Investigational Trial Site, Cleveland · TG Therapeutics Investigational Trial Site, Coeur d'Alene · TG Therapeutics Investigational Trial Site, Colorado Springs · TG Therapeutics Investigational Trial Site, Columbus · TG Therapeutics Investigational Trial Site, Cullman · TG Therapeutics Investigational Trial Site, Dallas · TG Therapeutics Investigational Trial Site, Denver · TG Therapeutics Investigational Trial Site, Detroit · TG Therapeutics Investigational Trial Site, Edinburg · TG Therapeutics Investigational Trial Site, Evanston · TG Therapeutics Investigational Trial Site, Farmington · TG Therapeutics Investigational Trial Site, Fort Collins · TG Therapeutics Investigational Trial Site, Franklin · TG Therapeutics Investigational Trial Site, Freehold · TG Therapeutics Investigational Trial Site, Fresno · TG Therapeutics Investigational Trial Site, Frisco · TG Therapeutics Investigational Trial Site, Gainesville · TG Therapeutics Investigational Trial Site, Gilbert · TG Therapeutics Investigational Trial Site, Glen Burnie · TG Therapeutics Investigational Trial Site, Golden Valley · TG Therapeutics Investigational Trial Site, Grand Junction · TG Therapeutics Investigational Trial Site, Greenfield · TG Therapeutics Investigational Trial Site, Hartford · TG Therapeutics Investigational Trial Site, Honolulu · TG Therapeutics Investigational Trial Site, Huntsville · TG Therapeutics Investigational Trial Site, Kirkland · TG Therapeutics Investigational Trial Site, Knoxville · TG Therapeutics Investigational Trial Site, Lake Success · TG Therapeutics Investigational Trial Site, Las Vegas · TG Therapeutics Investigational Trial Site, Lexington · TG Therapeutics Investigational Trial Site, Lincoln · TG Therapeutics Investigational Trial Site, Livingston · TG Therapeutics Investigational Trial Site, Louisville · TG Therapeutics Investigational Trial Site, Lubbock · TG Therapeutics Investigational Trial Site, Maitland · TG Therapeutics Investigational Trial Site, Miami · TG Therapeutics Investigational Trial Site, Milwaukee · TG Therapeutics Investigational Trial Site, Mobile · TG Therapeutics Investigational Trial Site, Morgantown · TG Therapeutics Investigational Trial Site, Mount Juliet · TG Therapeutics Investigational Trial Site, Naples · TG Therapeutics Investigational Trial Site, Nashville · TG Therapeutics Investigational Trial Site, Neenah · TG Therapeutics Investigational Trial Site, Neptune City · TG Therapeutics Investigational Trial Site, New Bern · TG Therapeutics Investigational Trial Site, Newport Beach · TG Therapeutics Investigational Trial Site, New York · TG Therapeutics Investigational Trial Site, Norfolk · TG Therapeutics Investigational Trial Site, Norman · TG Therapeutics Investigational Trial Site, Ogden · TG Therapeutics Investigational Trial Site, Omaha · TG Therapeutics Investigational Trial Site, Orange · TG Therapeutics Investigational Trial Site, Orlando · TG Therapeutics Investigational Trial Site, Owosso · TG Therapeutics Investigational Trial Site, Paramus · TG Therapeutics Investigational Trial Site, Pensacola · TG Therapeutics Investigational Trial Site, Phoenix · TG Therapeutics Investigational Trial Site, Plymouth · TG Therapeutics Investigational Trial Site, Portland · TG Therapeutics Investigational Trial Site, Raleigh · TG Therapeutics Investigational Trial Site, Rochester Hills · TG Therapeutics Investigational Trial Site, Roeland Park · TG Therapeutics Investigational Trial Site, Salem · TG Therapeutics Investigational Trial Site, Salt Lake City · TG Therapeutics Investigational Trial Site, San Antonio · TG Therapeutics Investigational Trial Site, Savannah · TG Therapeutics Investigational Trial Site, Scottsdale · TG Therapeutics Investigational Trial Site, Smyrna · TG Therapeutics Investigational Trial Site, Spring Hill · TG Therapeutics Investigational Trial Site, Teaneck · TG Therapeutics Investigational Trial Site, The Bronx · TG Therapeutics Investigational Trial Site, Toledo · TG Therapeutics Investigational Trial Site, Urbana · TG Therapeutics Investigational Trial Site, Vienna · TG Therapeutics Investigational Trial Site, Virginia Beach · TG Therapeutics Investigational Trial Site, Washington D.C. · TG Therapeutics Investigational Trial Site, Waukesha · TG Therapeutics Investigational Trial Site, West Hollywood · TG Therapeutics Investigational Trial Site, Weston
Registry updated 2026-10-30
NCT07609719
A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy
Trial Treatment · Phase 4 · Genentech, Inc.
Atlanta Neuroscience Institute, Atlanta · Alabama Neurology Associates, Birmingham · Neurology Clinic, PC, Cordova · Advanced Neurology of Colorado, LLC, Fort Collins · Neurology Associates PA, Maitland · Savannah Neurology Specialists,PC, Savannah · Clinical Endpoints, LLC, Scottsdale
Registry updated 2026-10-30
NCT07840326
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
Trial Treatment · Phase 2 · Sundance Biosciences, Inc.
Local Institution - Site 102, Atlanta · Local Institution - Site 104, Columbus · Local Institution - Site 107, Dallas · Local Institution - Site 105, Oklahoma City · Local Institution - Site 101, Raleigh · Local Institution - Site 106, Stony Brook · Local Institution - Site 103, Tampa
Registry updated 2026-10-30
NCT01730131
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-29
NCT06433765
A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
Research · TG Therapeutics, Inc.
BRIUMVI® Pregnancy Registry Virtual Research Coordination Center, Wilmington
Registry updated 2026-10-29
NCT07220252
Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis
Trial Treatment · Phase 2/3 · TG Therapeutics, Inc.
TG Therapeutics Investigational Trial Site, Salt Lake City
Registry updated 2026-10-29
NCT07615725
Dry Needling in Multiple Sclerosis
Trial Treatment · University of South Florida
University of South Florida, Tampa
Registry updated 2026-10-29
NCT06453694
Efgartigimod for the Treatment of Acute Optic Neuritis
Trial Treatment · Phase 2 · Anastasia Vishnevetsky, MD, MPH
Massachusetts Eye and Ear Infirmary, Boston · Massachusetts General Hospital, Boston
Registry updated 2026-10-28
NCT02486562
iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis
Research · Accelerated Cure Project for Multiple Sclerosis
Accelerated Cure Project, Waltham
Registry updated 2026-10-27
NCT06680037
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
Trial Treatment · Phase 1 · TG Therapeutics, Inc.
TG Therapeutics Investigational Trial Site, Ann Arbor · TG Therapeutics Investigational Trial Site, Cleveland · TG Therapeutics Investigational Trial Site, Columbus · TG Therapeutics Investigational Trial Site, La Jolla · TG Therapeutics Investigational Trial Site, Milwaukee · TG Therapeutics Investigational Trial Site, New York · TG Therapeutics Investigational Trial Site, Omaha · TG Therapeutics Investigational Trial Site, Rochester
Registry updated 2026-10-27
NCT06782490
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Trial Treatment · Phase 2 · Celgene
Local Institution - 0017, Aurora · Alabama Neurology Associates, Birmingham · University of Cincinnati Medical Center, Cincinnati · Local Institution - 0069, Columbus · Riverside Methodist Hospital, Columbus · Local Institution - 0080, Farmington · Neurology Center of New England, Foxborough · University of Kansas Medical Center, Kansas City · EvergreenHealth Medical Center, Kirkland · Hope Neurology, Knoxville · Prime Clinical Research, Lewisville · Aqualane Clinical Research, Naples · Thomas Jefferson University, Jefferson Headache Center, Philadelphia · Perseverance Research Center, LLC, Scottsdale · Northwest Neurology, Southfield · Washington University School of Medicine, St Louis · USF Health, Tampa
Registry updated 2026-10-27
NCT07299019
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Trial Treatment · Phase 3 · Zenas BioPharma (USA), LLC
University of New Mexico, School of Medicine, Albuquerque · SFM Clinical Research LLC, Boca Raton · Boston Clinical Trials, Boston · Nova Clinical Research, LLC, Bradenton · MS and Neuromuscular Center of Excellence, Clearwater · The Boster Center for Multiple Sclerosis, Columbus · The Ohio State University Wexner Medical Center (OSUWMC), Columbus · Neurology Clinic, P.C., Cordova · Fullerton Neurology and Headache Center, Fullerton · Premier Neurology, Greenville · Josephson Wallack Munshower Neurology, Pc Suite 225, Indianapolis · Neurology Associates, Maitland · Aqualane Clinical Research, Naples · Mount SInai Medical Center, New York · OMRF Multiple Sclerosis Center of Excellence, Oklahoma City · Arizona Neuroscience Research, LLC, Phoenix · Profound Research LLC at Oakland Neurology Center, Rochester Hills · KC Research Center, PA Neurology Research Dept, Roeland Park · Lone Star Neurology, San Antonio · Perseverance Research Center, LLC (PRC), Scottsdale · Texas Institute for Neurological Disorders - Sherman, Sherman · Washington University School of Medicine, St Louis · University of South Florida Department of Neurology - MS Division, Tampa · Harbor-UCLA Medical Center - The Lundquist Institute (Los Angeles Biomedical Research Institute (LA BioMed)), Torrance · Regina Berkovich MD PhD Inc, West Hollywood · University of Massachusetts Memorial Medical Center, Worcester
Registry updated 2026-10-27
NCT07897760
Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple Sclerosis
Trial Treatment · Otto Bock Healthcare Products GmbH
Shirley Ryan AbilityLab, Chicago
Registry updated 2026-10-27
NCT00001248
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-26
NCT06846281
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Trial Treatment · Phase 3 · Novartis Pharmaceuticals
University of New Mexico, Albuquerque · Neurology of Central FL Res Ctr, Altamonte Springs · Austin Regional Clinic, Austin · Tufts Medical Center, Boston · SUNY Buffalo The Jacobs Neuro Inst, Buffalo · Lahey Hospital and Medical Center, Burlington · Premier Health, Centerville · University of North Carolina, Chapel Hill · Rush University Medical Center, Chicago · University of Chicago, Chicago · Univ of Cincinnati Medical Center, Cincinnati · Cleveland Clinic Foundation, Cleveland · Ohio Health Research Institute, Columbus · Univ of Texas Southwest Med Center, Dallas · Sanford Health, Fargo · Michigan Institute of Neurological, Farmington Hills · John Peter Smith Hospital, Fort Worth · Neurology Center of New England, PC, Foxborough · University of Florida, Gainesville · Center for Neurological Disorders G, Greenfield · Premier Neurology, Greenville · Memorial Healthcare System, Hollywood · University of California, Irvine, Irvine · University of Kansas Hospital, Kansas City · Sibyl Wray MD Neurology PC, Knoxville · Cleveland Clinic Foundation, Las Vegas · Neurology Associates PA, Maitland · Elite Clinical Research, Miami · Medical College of Wisconsin, Milwaukee · Aqualane Clinical Research, Naples · Medstar Montgomery Medical Center, Olney · Advent Health Orlando, Orlando · Orlando Health Clinical Trials, Orlando · Memorial HC Ins for Neuroscience, Owosso · Saturn Research Solutions LLC, Plano · Providence Neurological Services West, Portland · Velocity Clinical Research, Raleigh · Virginia Commonwealth University, Richmond · Perseverance Research Center, Scottsdale · WA Uni School Of Med, St Louis · Tallahassee Neurological Clinic, Tallahassee · University of South Florida, Tampa · Holy Name Medical Center, Teaneck · Vero Beach Neurology, Vero Beach · MedStar Washington Hospital Center, Washington D.C.
Registry updated 2026-10-26
NCT07011914
Care in Multiple Sclerosis (MS)
Research · NYU Langone Health
University of Colorado Denver, Aurora · University of Alabama at Birmingham, Birmingham · Massachusetts General Hospital, Boston · Cleveland Clinic, Cleveland · Baylor College of Medicine, Houston · University of California San Francisco, San Francisco
Registry updated 2026-10-26
NCT05877963
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
Trial Treatment · Phase 3 · TG Therapeutics, Inc.
TG Therapeutics Investigational Trial Site, Atlanta · TG Therapeutics Investigational Trial Site, Birmingham · TG Therapeutics Investigational Trial Site, Boston · TG Therapeutics Investigational Trial SiteCharlotte, Charlotte · TG Therapeutics Investigational Trial Site, Chicago · TG Therapeutics Investigational Trial Site, Cincinnati · TG Therapeutics Investigational Trial Site, Cleveland · TG Therapeutics Investigational Trial Site, Cullman · TG Therapeutics Investigational Trial Site, Dayton · TG Investigational Site, Farmington · TG Investigational Site, Fort Collins · TG Therapeutics Investigational Trial Site, Foxborough · TG Therapeutics Investigational Trial Site, Golden Valley · TG Therapeutics Investigational Trial Site, Greenville · TG Therapeutics Investigational Trial Site, Houston · TG Therapeutics Investigational Trial Site, Indianapolis · TG Therapeutics Investigational Trial Site, Iowa City · TG Therapeutics Investigational Trial Site, Kirkland · TG Therapeutics Investigational Trial Site, Knoxville · TG Therapeutics Investigational Trial Site, Lutherville · TG Therapeutics Investigational Trial Site, Milwaukee · TG Therapeutics Investigational Trial Site, New York · TG Therapeutics Investigational Trial Site, North Worcester · TG Therapeutics Investigational Trial Site, Oklahoma City · TG Therapeutics Investigational Trial Site, Orange · TG Therapeutics Investigational Trial Site, Overland Park · TG Therapeutics Investigational Trial Site, Plymouth · TG Therapeutics Investigational Trial Site, Raleigh · TG Therapeutics Investigational Trial Site, Salt Lake City · TG Therapeutics Investigational Trial Site, Savannah · TG Therapeutics Investigational Trial Site, Seattle · TG Therapeutics Investigational Trial Site, Spokane · TG Therapeutics Investigational Trial Site, St Louis · TG Therapeutics Investigational Trial Site, Tampa · TG Therapeutics Investigational Trial Site, Vienna · TG Therapeutics Investigational Trial Site, Washington D.C. · TG Therapeutics Investigational Trial Site, Wellesley
Registry updated 2026-10-23
NCT06495138
Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
Trial Treatment · Emory University
Emory Univeristy, Atlanta
Registry updated 2026-10-23
NCT07891520
Efficacy of Seated Physical Activity INtervention(SPIN) for Wheelchair Users With Multiple Sclerosis
Trial Treatment · The University of Texas Health Science Center, Houston
The University of Texas Health Science Center at Houston, Houston
Registry updated 2026-10-23
NCT03109288
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
Trial Treatment · Phase 1/2 · National Institute of Allergy and Infectious Diseases (NIAID)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-10-20

All Multiple sclerosis trials and the map

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