Neuroblastoma trials in United States

In United States 59 Also abroad 128

59 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Pediatric Precision Laboratory Advanced Neuroblastoma Therapy
Where
Augusta, Austin, Birmingham, Boise, Charleston, Charlotte, Chicago, Dallas, Grand Rapids, Hackensack, Hartford, Hershey, Honolulu, Kansas City, Little Rock, Louisville, Miami, Minneapolis, Oakland, Orlando, Portland, San Diego, St Louis, Tampa
Age
Up to 22 years
People
500 worldwide
Run by
Giselle Sholler
See details and how to joinNCT02559778
No phaseTaking people
International Congenital Central Hypoventilation Syndrome (CCHS) Registry and CCHS SHARE
Where
Chicago
People
1,000
Run by
Ilya Khaytin
See details and how to joinNCT03088020
No phaseTaking people
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Where
Chicago, Los Angeles, Philadelphia, Seattle
Age
3 years to 85 years
People
1,000
Run by
Ilya Khaytin
See details and how to joinNCT03568669
Phase 1/2Taking people
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Where
Birmingham, Dallas, Gainesville, Hackensack, Hartford, Hershey, Honolulu, Kansas City, Little Rock, Miami, Nashville, Orlando, St Louis, Tampa
Age
Up to 26 years
People
265
Run by
Milton S. Hershey Medical Center
See details and how to joinNCT06465199
Phase 2Taking people
Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma
Where
Austin, Dallas, Durham, Hartford, Hershey, Honolulu, Little Rock, Miami, Nashville, Orlando, Portland, St Louis
Age
1 year to 21 years
People
98
Run by
Giselle Sholler
See details and how to joinNCT06540963
Phase 1Taking people
B7-H3.CD28Z.CART in Solid Tumors
Where
Boston
Age
9 months to 30 years
People
40
Run by
Robbie Majzner
See details and how to joinNCT07358260
Phase 2Taking people
N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma
Where
New York
Age
18 months to 19 years
People
45
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06528496
Phase 3Taking people
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)
Where
Albany, Albuquerque, Allentown, Ann Arbor, Asheville, Atlanta, Aurora, Austin, Baltimore, Bangor, Bethesda, Birmingham, Boise, Boston, Brooklyn, Buffalo, Burlington, Chapel Hill, Charleston, Charlotte, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Corpus Christi, Dallas, Danville, Dayton, Denver, Des Moines, Detroit, Downey, Durham, East Lansing, El Paso, Fargo, Fort Myers, Fort Worth, Gainesville, Grand Rapids, Green Bay, Greenville, Hackensack, Hartford, Hershey, Hollywood, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Loma Linda, Los Angeles, Lubbock, Madera, Madison, Marshfield, Memphis, Miami, Milwaukee, Mineola, Minneapolis, Morgantown, Morristown, Nashville, Newark, New Brunswick, New Haven, New Hyde Park, New Orleans, New York, Oakland, Oak Lawn, Oklahoma City, Omaha, Orange, Orlando, Palo Alto, Park Ridge, Paterson, Peoria, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Richmond, Rochester, Royal Oak, Sacramento, Salt Lake City, San Antonio, San Diego, San Francisco, Savannah, Scarborough, Seattle, Sioux Falls, Spokane, Springfield, St Louis, Stony Brook, St. Petersburg, Syracuse, Tacoma, The Bronx, Toledo, Valhalla, Washington D.C., West Palm Beach, Wilmington, Winston-Salem
Age
365 days to 30 years
People
750 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT03126916
Phase 1/2Taking people
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Where
Ann Arbor, Atlanta, Aurora, Birmingham, Boston, Chicago, Cincinnati, Houston, Indianapolis, Los Angeles, Memphis, Minneapolis, New York, Orange, Palo Alto, Philadelphia, Pittsburgh, San Francisco, Seattle, St Louis, Washington D.C.
Age
12 months to 30 years
People
147
Run by
Children's Oncology Group
See details and how to joinNCT04851119
Phase 2Taking people
Haploidentical Donor Cytokine-Induced Memory-Like Natural Killer Cells (CIML-NK) for Relapsed & Refractory Neuroblastoma
Where
Cincinnati
Age
1 year to 39 years
People
20
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT07635056
Phase 2Not yet taking people in United States
NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + Dinutuximab
Where
Ann Arbor, Atlanta, Aurora, Boston, Chicago, Cincinnati, Dalls, Fort Worth, Los Angeles, Memphis, Philadelphia, San Francisco, Seattle
Age
1 year to 30 years
People
118
Run by
New Approaches to Neuroblastoma Therapy Consortium
See details and how to joinNCT07261241
Phase 1Enrolling by invitation
GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma
Where
Philadelphia
Age
1 year and over
People
45
Run by
Stephan Grupp MD PhD
See details and how to joinNCT05650749
Phase 1Taking people
Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)
Where
Washington D.C.
Age
1 year to 23 years
People
18
Run by
Children's National Research Institute
See details and how to joinNCT07172958
Phase 2Taking people
Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma
Where
Augusta, Austin, Birmingham, Charleston, Charlotte, Durham, Gainesville, Hartford, Hershey, Honolulu, Little Rock, Louisville, Miami, Minneapolis, Oakland, Orlando, Portland, Richmond, San Diego, St Louis, Winston-Salem
Age
12 months to 21 years
People
93 worldwide
Run by
Giselle Sholler
See details and how to joinNCT05489887 · EU 2025-524140-35-00
Phase 1/2Taking people
SPEARHEAD-3 Pediatric Study
Where
Bethesda, Boston, Cincinnati, Durham, Madison, New York, Palo Alto, Philadelphia, Seattle, St Louis
Age
2 years to 21 years
People
20
Run by
USWM CT, LLC
See details and how to joinNCT05642455
Phase 2Taking people
A Phase II Study With a Safety Run-In of the Addition of N-803 to a Chemoimmunotherapy Backbone for the Treatment of Patients With Relapsed or Refractory Neuroblastoma
Where
Ann Arbor, Aurora, Memphis, Philadelphia, San Francisco
Age
Up to 30 years
People
54
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT07085338
Phase 1Taking people
NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma
Where
Houston
Age
1 year to 24 years
People
27
Run by
Baylor College of Medicine
See details and how to joinNCT07211737
Phase 2Taking people
NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial
Where
Ann Arbor, Aurora, Boston, Chicago, Cincinnati, Columbus, Dallas, Fort Worth, Los Angeles, Memphis, Philadelphia, San Francisco, Seattle
Age
1 year to 31 years
People
62
Run by
New Approaches to Neuroblastoma Therapy Consortium
See details and how to joinNCT06450041
Phase 1Taking people
Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma
Where
Boston
Age
1 year to 30 years
People
18
Run by
Steven DuBois, MD
See details and how to joinNCT07027748
Phase 1/2Taking people
Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
Where
Gainesville
Age
6 months to 25 years
People
27
Run by
University of Florida
See details and how to joinNCT06625190
No phaseTaking people
Familial Investigations of Childhood Cancer Predisposition
Where
Memphis
People
1,500
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT03050268
Phase 2Taking people
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma
Where
New York
Age
1 year and over
People
200
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT00107289
Phase 1Taking people
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
Where
Memphis
Age
Up to 21 years
People
48
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT04897321
Phase 1/2Taking people
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
Where
Atlanta, Aurora, Houston, Memphis, Minneapolis, Palo Alto, Washington D.C.
Age
12 months to 30 years
People
90 worldwide
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT04901702
Phase 1Taking people
Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors
Where
Palo Alto
Age
2 years to 30 years
People
41
Run by
Stanford University
See details and how to joinNCT06500819