Post-traumatic stress disorder (PTSD) trials in United States

In United States 332 Also abroad 523

332 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Inflammatory Challenge and Fear
Where
San Francisco
Age
18 years to 65 years
People
288
Run by
University of California, San Francisco
See details and how to joinNCT06630884
No phaseTaking people
Multifaceted Intervention to Restore Resilience and Overcome Risk
Where
Houston
Age
18 years and over
People
136
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06988787
Phase 2Taking people
Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults
Where
Omaha
Age
21 years to 65 years
People
140
Run by
University of Nebraska
See details and how to joinNCT05269459
No phaseTaking people
Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples
Where
San Antonio
Age
18 years and over
People
120
Run by
Penn State University
See details and how to joinNCT06047691
Phase 3Taking people
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)
Where
Atlanta, Austin, Cherry Hill, Chicago, Creve Coeur, Draper, El Paso, Evergreen, Houston, Imperial, Independence, Jacksonville, La Jolla, Lauderhill, Little Rock, Los Angeles, Madison, Maitland, Memphis, Montclair, New Orleans, New York, Oceanside, Orange, Orem, Orlando, Phoenix, Pikesville, Plymouth Meeting, Princeton, Saint Charles, San Juan Capistrano, Seattle, Toms River, Tucson, West Chester, Worcester
Age
18 years and over
People
300
Run by
Transcend Therapeutics
See details and how to joinNCT07456696
Early phase 1Taking people
Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers
Where
New York
Age
18 years and over
People
20
Run by
Weill Medical College of Cornell University
See details and how to joinNCT04887116
No phaseTaking people
Targeted Plasticity Therapy for PTSD
Where
Austin, Dallas, Richardson
Age
22 years to 79 years
People
20
Run by
The University of Texas at Dallas
See details and how to joinNCT06266364
Phase 2Taking people
Focused Ultrasound for PTSD in Veterans
Where
Providence
Age
22 years to 70 years
People
60
Run by
VA Office of Research and Development
See details and how to joinNCT06820138
No phaseTaking people
Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress
Where
Chicago
Age
8 years to 18 years
People
400
Run by
Anthony Vesco
See details and how to joinNCT07483333
No phaseTaking people
Efficacy of a Multi-level School Intervention for LGBTQ Youth
Where
El Monte, Glendale, Inglewood, La Crescenta-Montrose, Long Beach, Los Angeles, Lynwood, Pasadena, Rosemead, St Louis
Age
12 years to 20 years
People
228
Run by
Washington University School of Medicine
See details and how to joinNCT05541406
No phaseTaking people
Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course
Where
Charleston, Houston, New Orleans, Phoenix
Age
18 years and over
People
280
Run by
United States Department of Defense
See details and how to joinNCT06957067
No phaseTaking people
A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD
Where
Charleston, Minneapolis, Phoenix, San Diego
Age
18 years and over
People
420
Run by
United States Department of Defense
See details and how to joinNCT06990191
No phaseTaking people
A Neurosensory Account of Anxiety and Stress (Study 2)
Where
Houston
Age
18 years to 50 years
People
160
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT07079839
No phaseEnrolling by invitation
Clinician Supported Mobile App to Reduce Mental Health Symptoms Among World Trade Center Responders in Florida
Where
Miami
People
120
Run by
Florida International University
See details and how to joinNCT06648928
No phaseTaking people
Testing a Scalable Model of Care to Improve Patients Access to Mental Health Services After Traumatic Injury
Where
Washington
Age
16 years and over
People
350
Run by
Medical University of South Carolina
See details and how to joinNCT05497115
No phaseTaking people
The PREVENT Resilience Study
Where
Atlanta
Age
18 years to 65 years
People
50
Run by
Emory University
See details and how to joinNCT07568145
Phase 1Taking people
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)
Where
Baltimore
Age
21 years and over
People
40
Run by
Johns Hopkins University
See details and how to joinNCT06989957
Phase 3Enrolling by invitation
An Evaluation of the Long-Term Safety and Efficacy of TSND-201 for the Treatment of PTSD
Where
Austin, Creve Coeur, Draper, El Paso, Evergreen, Independence, Jacksonville, Lauderhill, Little Rock, Los Angeles, Maitland, Montclair, Orem, Orlando, Plymouth Meeting, Toms River, Worcester
People
300
Run by
Transcend Therapeutics
See details and how to joinNCT07670702
No phaseTaking people
Resilient Roots: Supporting Youth and Families
Where
Rochester
Age
10 years to 15 years
People
60
Run by
University of Rochester
See details and how to joinNCT06535516
No phaseTaking people
Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
Where
New Haven
Age
18 years to 70 years
People
150
Run by
Yale University
See details and how to joinNCT06371404
No phaseNot yet taking people in United States
Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms
Where
Durham, Syracuse
Age
18 years and over
People
200
Run by
VA Office of Research and Development
See details and how to joinNCT07202325
No phaseTaking people
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Where
Durham, Los Angeles
Age
18 years to 70 years
People
80
Run by
Duke University
See details and how to joinNCT05120635
No phaseTaking people
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
Where
Fort Hood
Age
18 years and over
People
30
Run by
The University of Texas Health Science Center at San Antonio
See details and how to joinNCT07351305
No phaseTaking people
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Where
Atlanta, Chicago, Cleveland, New Orleans, San Diego, Tampa
Age
18 years and over
People
200
Run by
Veterans Medical Research Foundation
See details and how to joinNCT06296186
Phase 2Taking people
KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury
Where
Salt Lake City
Age
18 years to 65 years
People
12
Run by
Irma Fleming
See details and how to joinNCT07563296