Sarcoma: open trials in France

• NCT06395103

  Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

  Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC

  Centre hospitalier Universitaire de Bordeaux, Bordeaux · Centre Leon Berard, Lyon · Assistance Publique Hôpitaux de Marseille, Marseille · Centre Hospitalier Universitaire de Nantes, Nantes · Institut Gustave Roussy, Villejuif

  Registry updated 2026-10-30

• NCT06441331

  Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors

  Trial Treatment · Phase 1 · ITM Solucin GmbH

  Centre Hospitalier Regional De Marseille, Marseille · Institut Gustave Roussy, Villejuif

  Registry updated 2026-10-27

• NCT06345729

  A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

  Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC

  Centre Hospitalier d'Avignon, Avignon · Hôpital Ambroise-Paré, Boulogne-Billancourt · Centre Jean Perrin, Clermont Ferrand Cedex1 · Centre Hospitalier Universitaire de Dijon, Dijon · Centre Hospitalier Universitaire de Nice, Nice · Centre Hospitalier Universitaire De Nimes, Nimes Cedex 9 · Centre Hospitalier Intercommunal De Cornouaille, Quimper Cedex · Assoc Hospitaliere Nord Artois Clinique, Valenciennes

  Registry updated 2026-10-26

• NCT07871864

  Fight Osteosarcoma Through European Research Evolving Study Platform From Diagnosis to Relapse

  Trial Treatment · Phase 3 · Gustave Roussy, Cancer Campus, Grand Paris

  CHU Amiens-Picardie - Site Sud, Amiens · CHU Angers, Angers · CHRU Besançon - Hopital Jean Minjoz - Service d'Oncologie Médicale, Besançon · CHU de Bordeaux - Groupe Hospitalier Pellegrin, Bordeaux · Institut Bergonie, Bordeaux · Chu Brest Hopital Morvan, Brest · Chu Caen Normandie, Caen · CHU François Mitterrand, Dijon · CHU Grenoble, Hôpital Couple-enfant, Grenoble · CHU de la Réunion, La Réunion · Centre Oscar Lambret, Lille · CHU Limoges, Limoges · Centre Leon Berard, Lyon · Hopital de la Timone - Service d'Hématologie et Oncologie Pédiatrique, Marseille · Hopital de la Timone - Service d'Oncologie médicale, Marseille · CHU Arnaud de Villeneuve, Montpellier · CHU Nantes - Hôpital Femme-Enfant-Adolescent, Nantes · CHU Nice, Nice · Hôpital Armand-Trousseau, Paris · Hôpital Cochin, Paris · Institut Curie, Paris · CHU Poitiers, Poitiers · CHU Reims, Reims · CHU Rennes - Hôpital Sud, Rennes · Centre Eugène Marquis, Rennes · CHU Charles Nicolle, Rouen · CHU Saint Etienne Hôpital Nord, Saint-Etienne · INSTITUT DE CANCEROLOGIE DE L'OUEST - Site Saint-Herblain, Saint-Herblain · Hôpital de Hautepierre, Strasbourg · Centre Paul Strauss, Strasbourg · Oncopole Claudius Regaud IUCT ONCOPOLE, Toulouse · CHU Toulouse Hôpital des Enfants, Toulouse · CHU Tours Hôpital Bretonneau, Tours · CHRU Nancy Hôpital d'enfants, Vandœuvre-lès-Nancy · Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy · Gustave Roussy, Villejuif

  Registry updated 2026-10-26

• NCT04307277

  Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue Sarcoma

  Trial Treatment · Phase 3 · Institut Claudius Regaud

  CHU Besancon, Besancon Cedex · Centre Francois Baclesse, Caen Cedex 5 · Centre Jean Perrin, Clermont-Ferrand · Centr Georges Francois Leclerc, Dijon · Centre Hospitalier Et Universitaire de Limoges, Limoges · Centre Leon Berard, Lyon · Centre Hospitalier Regional De Marseille, Marseille · Institut Paoli-Calmettes, Marseille · Institut Regional Du Cancer De Montpellier, Montpellier Cedex 5 · Centre Antoine Lacassagne, Nice Cedex 2 · Assistance Publique Hopitaux de Paris, Paris · Centre Hospitalier Universitaire de Poitiers, Poitiers · Institut Godinot, Reims · Centre De Lutte Contre Le Cancer Eugene Marquis, Rennes Cedex · Centre Henri Becquerel, Rouen · Institut De Cancerologie De L Ouest, Saint-Herblain Cedex · Institut de Cancérologie Strasbourg Europe, Strasbourg · Les Hopitaux Universitaires De Strasbourg, Strasbourg Cedex 2 · Oncopole Claudius Regaud, Toulouse · Institut de cancérologie de Lorraine, Vandoeuvre Les Nancy_ Cedex · Institut Gustave Roussy, Villejuif

  Registry updated 2026-10-16

• NCT07541170

  A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

  Trial Treatment · Phase 3 · Hoffmann-La Roche

  Centre Hospitalier d'Avignon, Avignon · Hospices Civils de Lyon, Bron · Centre Francois Baclesse, Caen Cedex 5 · University Hospital Of Clermont-Ferrand, Clermont Ferrand Cedex 1 · Centre Leon Berard, Lyon · Centre Hospitalier Universitaire De Montpellier, Montpellier Cedex 5 · Centre Hospitalier Intercommunal De Cornouaille, Quimper Cedex · Centre Hospitalier Universitaire Reims, Reims Cedex · Centre Hospitalier Universitaire de Nantes, Saint-Herblain · Les Hopitaux Universitaires De Strasbourg, Strasbourg Cedex · Hospital Foch, Suresnes · Institut Gustave Roussy, Villejuif

  Registry updated 2026-10-13

• NCT07261631

  Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

  Trial Treatment · Phase 1 · Novartis Pharmaceuticals

  Novartis Investigative Site, Vandœuvre-lès-Nancy

  Registry updated 2026-10-09

• NCT02789384

  CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study.

  Trial Treatment · Institut Bergonié

  Institut Bergonie, Bordeaux · Centre Georges François Leclerc, Dijon · Centre Oscar Lambret, Lille · Centre Leon Berard, Lyon · AP-HM - Hopital de la Timone, Marseille · Institut Paoli-Calmettes, Marseille · Institut de Cancérologie de l'Ouest, Nantes · Institut Curie, Paris · Institut Claudius Regaud - IUCT-0, Toulouse · Institut Gustave Roussy, Villejuif

  Registry updated 2026-10-08

• NCT07864870

  Sarcoma Care Adherence and Survival in Strasbourg

  Research · University Hospital, Strasbourg, France

  Service d'hématologie-oncologie pédiatrique - CHU de Strasbourg - France, Strasbourg

  Registry updated 2026-10-08

• NCT04031677

  Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

  Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC

  Centre Leon Berard, Lyon · Institut du Cancer de Montpellier, Montpellier · Institut Curie- Hopital de Paris, Paris · Hopitaux Universitaires de Strasbourg - Hautepierre, Strasbourg · Institut Gustave Roussy, Villejuif

  Registry updated 2026-10-07

• NCT06641908

  Anti-GD2 ADC M3554 in Advanced Solid Tumors

  Trial Treatment · Phase 1 · EMD Serono Research & Development Institute, Inc.

  Institut Bergonié - Service d'Oncologie Médicale, Bordeaux · Centre Oscar Lambret - cancerologie generale, Lille · Centre Leon Berard - Service d'Oncologie Medicale, Lyon · Centre Antoine Lacassagne - Service d'Hématologie Oncologie, Nice

  Registry updated 2026-10-07

• NCT06760819

  A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

  Trial Treatment · Phase 2 · Bayer

  Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale, Bordeaux · CHU Brest - Hopital La Cavale Blanche - service oncologie medicale, Brest · Centre Oscar Lambret - Service Oncologie, Lille · ICM - Institut du Cancer de Montpellier - Val d'Aurelle - CIPP, Montpellier · Centre Hospitalier Lyon Sud - Service oncologie medicale, Pierre-Bénite · Institut Gustave Roussy - Departement d'Innovation Therapeutique et d'Essais Precoces (DITEP), Villejuif

  Registry updated 2026-10-02

• NCT07602777

  A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)

  Trial Treatment · Phase 1/2 · GlaxoSmithKline

  GSK Investigational Site, Bordeaux · GSK Investigational Site, Lyon · GSK Investigational Site, Villejuif

  Registry updated 2026-10-01

• NCT07853105

  Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors.

  Trial Treatment · Phase 1/2 · University Hospital, Strasbourg, France

  Oncologie Médicale-Institut Bergonié, Bordeaux · Unité d'Hémato-Oncologie Pédiatrique (UHOP) -CHU de Bordeaux - GH Pellegrin, Bordeaux · Oncologie - Unité pédiatrique Centre Oscar Lambret, Lille · Institut d'hématologie et d'oncologie Pédiatrique iHOPE, Lyon · Oncologie médicale adulte- Centre Léon Bérard, Lyon · Hématologie, Immunologie et Oncologie Pédiatrique (HIOP), CHU Timone Enfants,, Marseille · Onco-hématologie pédiatrique- CHRU NANCY-BRABOIS, Nancy · Oncopédiatrie-SIREDO - Institut Curie, Paris · Oncologie Médicale - Institut Curie, Paris · Onco-hématologie pédiatrique- Hôpitaux Universitaires de Strasbourg, Strasbourg · Oncologie médicale, Hôpitaux Universitaires de Strasbourg, Strasbourg · Unité d'Hématologie Immunologie Oncologie Pédiatrique, CHU Toulouse, Toulouse

  Registry updated 2026-10-01

• NCT06881992

  A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

  Trial Treatment · Phase 3 · Rezolute

  Investigative Site, Clichy

  Registry updated 2026-09-28

• NCT04094610

  A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

  Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.

  Centre Hospitalier Universitaire D'Angers, Angers · Pellegrin Hospital, Bordeaux · Centre Leon Berard, Lyon · Assistance Publique Hôpitaux de Marseille, Marseille · Institut Gustave Roussy, Villejuif

  Registry updated 2026-09-25

• NCT07614620

  Effect of Hypnosis in the Management of Anxiety and Chemo-induced Symptoms in Adolescents and Young Adults With Sarcoma or Germ Cell Tumor and in Young Women With Breast Cancer

  Trial Treatment · Institut Bergonié

  Institut Bergonie, Bordeaux

  Registry updated 2026-09-22

• NCT07490106

  Benefits of Early Collaboration Between Oncologists and Palliative Care Physicians in Cases of Unplanned Hospitalization for Patients With Metastatic Cancer

  Trial Treatment · Centre Oscar Lambret

  Centre Oscar Lambret, Lille

  Registry updated 2026-09-17

• 2025-521702-18-00

  A phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-DFC413 and safety and imaging properties of [68Ga]Ga-NNS309 in patients with solid tumors

  Trial Treatment · Phase 1 · Novartis Pharma AG

  Centre Leon Berard, Lyon · Institut Paoli-Calmettes, Marseille · Oncopole Claudius Regaud, Toulouse · CHRU De Nancy, Vandoeuvre Les Nancy Cedex

  Registry updated 2026-09-15

• NCT07802652

  Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma

  Trial Treatment · Phase 2 · Gustave Roussy, Cancer Campus, Grand Paris

  Gustave Roussy, Villejuif

  Registry updated 2026-09-15

• NCT06797999

  First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma

  Trial Treatment · Phase 1/2 · Adcendo ApS

  Centre Leon Berard, Lyon · Institut Gustave Roussy, Villejuif

  Registry updated 2026-09-11

• 2025-523610-83-00

  Randomized study evaluating the impact of an innovative and cooperative pathway integrating oncogeriatric, pharmaceutical and pharmacological follow-up in elderly patients (>70 years old) presenting with cancer and treated with oral therapy_POG

  Trial Treatment · Phase 4 · Institut Gustave Roussy

  Hospital Femme Mere Enfant, Bron · Hospices Civils de Lyon_ Hôpital Fréderic Dugoujon, Caluire-et-Cuire · Gustave Roussy, Chevilly-Larue · Centr Georges Francois Leclerc, Dijon · Centre Hospitalier Universitaire De Lille, Lille Cedex · Hopital De La Croix-Rousse, Lyon Cedex 04 · Hôpital La Timone - APHM, Marseille · Hôpital Européen Georges Pompidou, Paris · Hopital Cochin - Port Royal, PARIS · Hopital Tenon, Paris Cedex 20 · Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite · Centre De Lutte Contre Le Cancer Eugene Marquis, Rennes Cedex · Institut Curie, Saint-Cloud · Les Hopitaux Universitaires De Strasbourg, Strasbourg Cedex 2 · Oncopole Claudius Regaud, Toulouse · Institut Gustave Roussy, Villejuif

  Registry updated 2026-09-08

• NCT03715933

  Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

  Trial Treatment · Phase 1 · Inhibrx Biosciences, Inc

  Centre Leon Berard, Lyon · Institut Gustave Roussy, Villejuif

  Registry updated 2026-09-08

• NCT05732831

  Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

  Trial Treatment · Phase 1/2 · Tango Therapeutics, Inc.

  CHU de Brest, Brest · Centre Berard Leon, Lyon · Institut de Cancerologie de l'Ouest - Hôpital Saint Herblain - PPDS, Saint-Herblain · Institute Gustav Roussy, Villejuif

  Registry updated 2026-09-08

• 2024-518199-30-00

  Phase I-II prospective trial, multicenter, open label, exploring the combination of Trabectedin plus RAdiotherapy in Soft Tissue Sarcoma patients

  Trial Treatment · Phase 1/2 · Asoc Grupo Espanol De Investigacion En Sarcomas

  Institut Bergonie, Bordeaux · Centre Leon Berard, Lyon

  Registry updated 2026-09-04

All Sarcoma trials and the map

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