Sarcoma: open trials in Netherlands

• NCT06395103

  Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

  Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC

  Prinses Maxima Centrum voor Kinderoncologie B.V., Utrecht

  Registry updated 2026-10-30

• NCT06345729

  A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

  Trial Treatment · Phase 3 · Merck Sharp & Dohme LLC

  Ziekenhuisgroep Twente Stichting, Almelo · Ziekenhuis Gelderse Vallei Stichting, Ede Gld · Ziekenhuis St Jansdal, Harderwijk · Universitair Medisch Centrum Utrecht, Utrecht · Isala Klinieken Stichting, Zwolle

  Registry updated 2026-10-26

• NCT07871864

  Fight Osteosarcoma Through European Research Evolving Study Platform From Diagnosis to Relapse

  Trial Treatment · Phase 3 · Gustave Roussy, Cancer Campus, Grand Paris

  University Medical Center Groningen, Groningen · Leiden University Medical Center, Leiden · Radboud University Medical Center, Nijmegen · Princess Máxima Center for Pediatric Oncology, Utrecht

  Registry updated 2026-10-26

• NCT06279130

  Pan-tumor neoadjuvant basket study of immune check-point inhibition and novel IO combinations (NEOASIS)

  Trial Treatment · Phase 2 · Netherlands Cancer Institute

  Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Amsterdam

  Registry updated 2026-10-21

• NCT07541170

  A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

  Trial Treatment · Phase 3 · Hoffmann-La Roche

  Zuyderland Medisch Centrum Stichting, Geleen · Jeroen Bosch Ziekenhuis Stichting, 'S-Hertogenbosch

  Registry updated 2026-10-13

• NCT04031677

  Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

  Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC

  The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis, Amsterdam · Leiden University Medical Centre, Leiden · Radboudumc - Radboud University Medical Center Nijmegen, Nijmegen

  Registry updated 2026-10-07

• NCT06881992

  A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

  Trial Treatment · Phase 3 · Rezolute

  Investigative Site, Rotterdam

  Registry updated 2026-09-28

• NCT03715933

  Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

  Trial Treatment · Phase 1 · Inhibrx Biosciences, Inc

  Universitair Medisch Centrum Groningen, Groningen · Leids Universitair Medisch Centrum (LUMC), Leiden

  Registry updated 2026-09-08

• NCT06644755

  First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

  Trial Treatment · Phase 1 · Daiichi Sankyo

  Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL), Amsterdam

  Registry updated 2026-09-04

• NCT07252739

  KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

  Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC

  Deventer Ziekenhuis, Deventer · Leids Universitair Medisch Centrum (LUMC), Leiden

  Registry updated 2026-09-02

• 2024-513033-21-00

  Long-Term Follow-Up (LTFU) of Participants Treated with Adoptive Cell Therapies

  Trial Treatment · Phase 1 · USWM Ct LLC

  Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Amsterdam

  Registry updated 2026-08-14

• NCT07377747

  Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Resectable Retroperitoneal Liposarcoma

  Research · Australia and New Zealand Sarcoma Association

  The Netherlands Cancer Institute, Amsterdam

  Registry updated 2026-07-15

• NCT07145450

  Master Protocol of TCR-modified T Cell Therapy Targeting HLA-restricted KRAS Antigen Administered in Adult Patients With Metastatic or Locally Advanced PDAC

  Trial Treatment · Phase 1/2 · Anocca AB

  Amsterdam UMC - VU Medical Center, Amsterdam · Radboud University Medical Center, Nijmegen

  Registry updated 2026-06-08

• NCT03093116

  A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

  Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.

  Netherlands Cancer Institute, Amsterdam · Universitair Medisch Centrum Groningen, Groningen

  Registry updated 2026-05-27

• 2024-514089-37-00

  Indocyanine Green and near infrared fLuorescence in paediatric Oncology surgery

  Trial Treatment · Phase 2 · The University Of Birmingham

  Prinses Maxima Centrum voor Kinderoncologie B.V., Utrecht

  Registry updated 2026-04-30

• 2025-523898-42-00

  The Surf trial

  Trial Treatment · Phase 2/3 · Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

  Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC), Rotterdam

  Registry updated 2026-04-28

• NCT07071727

  Short Course of Radiotherapy Prior to Surgery of Soft Tissue Sarcomas

  Trial Treatment · The Netherlands Cancer Institute

  Netherlands Cancer Institute, Amsterdam · AUMC, Amsterdam · UMCG, Groningen · LUMC, Leiden · Maastro, Maastricht · Radboudumc, Nijmegen

  Registry updated 2026-02-19

• NCT06645808

  PET-imaging of Two Vartumabs in Patients With Solid Tumors

  Trial Treatment · Early phase 1 · Var2 Pharmaceuticals

  Universitair Medisch Centrum Groningen, Groningen

  Registry updated 2025-12-29

• NCT06962072

  Outcomes Following Limb Sparing Surgery for Soft Tissue Sarcoma

  Research · Amsterdam UMC

  Amsterdam UMC, Amsterdam

  Registry updated 2025-12-19

• NCT05062707

  Early Ageing During Therapy in AYA Cancer Patients

  Research · University Medical Center Groningen

  University Medical Center Groningen, Groningen

  Registry updated 2025-05-13

• NCT06748872

  EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma

  Trial Treatment · Phase 1 · Medigene AG

  Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Amsterdam · Universitair Medisch Centrum Groningen, Groningen

  Registry updated 2024-12-27

• NCT06726512

  Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy

  Trial Treatment · University Medical Center Groningen

  University Medical Center Groningen, Groningen

  Registry updated 2024-12-10

• 2024-516078-31-00

  rEECur: International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma

  Trial Treatment · Phase 2/3 · The University Of Birmingham

  Radboud universitair medisch centrum Stichting, Nijmegen · Prinses Maxima Centrum voor Kinderoncologie B.V., Utrecht

  Registry updated 2024-12-04

• NCT04625907

  FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

  Trial Treatment · Phase 1/2 · University of Birmingham

  Universitair Medisch Centrum Groningen, Groningen · Prinses Maxima Centrum voor Kinderoncologie B.V., Utrecht

  Registry updated 2024-05-23

• NCT04832620

  Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas

  Research · Leiden University Medical Center

  HollandPTC, Delft · LUMC, Leiden

  Registry updated 2023-11-18

All Sarcoma trials and the map

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