Sarcoma: open trials in United States

• NCT02390752

  Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...

  Trial Treatment · Phase 1 · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-03

• NCT06176989

  Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors

  Trial Treatment · Phase 2 · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-03

• NCT06222203

  Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

  Research · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-03

• NCT06375122

  Natural History Study of Kaposi Sarcoma

  Research · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-03

• NCT06474676

  T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.

  Trial Treatment · Phase 1 · M.D. Anderson Cancer Center

  MD Anderson Cancer Center, Houston

  Registry updated 2026-11-03

• NCT07428993

  Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma

  Trial Treatment · Phase 2 · St. Jude Children's Research Hospital

  St. Jude Children's Research Hospital, Memphis

  Registry updated 2026-11-03

• NCT04222413

  Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

  Trial Treatment · Phase 1 · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda · University of Kansas, Fairway

  Registry updated 2026-11-02

• NCT05711615

  Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

  Trial Treatment · Phase 1 · National Cancer Institute (NCI)

  University of Michigan Rogel Cancer Center, Ann Arbor · UCHealth University of Colorado Hospital, Aurora · Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore · National Cancer Institute Developmental Therapeutics Clinic, Bethesda · Dana-Farber Cancer Institute, Boston · University of Virginia Cancer Center, Charlottesville · University of Chicago Comprehensive Cancer Center, Chicago · UT MD Anderson Cancer Center, Houston · USC / Norris Comprehensive Cancer Center, Los Angeles · Los Angeles General Medical Center, Los Angeles · University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami · UC Comprehensive Cancer Center at Silver Cross, New Lenox · University of Chicago Medicine-Orland Park, Orland Park · UPMC Hillman Cancer Center, Pittsburgh · Siteman Cancer Center-South County, St Louis · Washington University School of Medicine, St Louis

  Registry updated 2026-11-02

• NCT07227961

  Activation Sarcoma: PROMIS and Mobility Evaluation in Sarcoma Patients

  Research · University of Calgary

  Mayo Clinic, Phoenix · Mayo Clinic, Rochester

  Registry updated 2026-11-02

• NCT07283731

  Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue Sarcoma

  Trial Treatment · Phase 2 · M.D. Anderson Cancer Center

  MD Anderson Cancer Center, Houston

  Registry updated 2026-11-02

• NCT07658768

  Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric Patients

  Trial Treatment · Early phase 1 · Abramson Cancer Center at Penn Medicine

  Children's Hospital of Philadelphia, Phildelphia

  Registry updated 2026-11-02

• NCT06395103

  Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

  Trial Treatment · Phase 1/2 · Merck Sharp & Dohme LLC

  Children's Hospital Colorado-Center for Cancer and Blood Disorders ( Site 1016), Aurora · Dana-Farber Cancer Institute ( Site 1013), Boston · Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 1003), Fargo · Corewell Health ( Site 1001), Grand Rapids · University of Texas MD Anderson Cancer Center ( Site 1007), Houston · University of Iowa Health Care. ( Site 1017), Iowa City · Children's Mercy Hospital ( Site 1024), Kansas City · Children's Hospital Los Angeles ( Site 1006), Los Angeles · Rutgers Cancer Institute of New Jersey ( Site 1008), New Brunswick · Yale New Haven Hospital ( Site 1012), New Haven · Memorial Sloan Kettering Cancer Center ( Site 1010), New York · Children's Hospital of Philadelphia (CHOP) ( Site 1021), Philadelphia · Oregon Health and Science University ( Site 1004), Portland · Intermountain - Primary Children's Hospital ( Site 1014), Salt Lake City · Sanford Children's Hospital-Sanford Children's Specialty Clinic ( Site 1015), Sioux Falls · Johns Hopkins All Children's Hospital ( Site 1025), St. Petersburg · New York Medical College ( Site 1023), Valhalla

  Registry updated 2026-10-30

• NCT04557969

  Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

  Research · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-29

• NCT06503146

  18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

  Trial Treatment · Phase 2 · National Cancer Institute (NCI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-29

• NCT07297979

  Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

  Trial Treatment · Phase 1 · Amgen

  C S Mott Children's Hospital, Ann Arbor · Johns Hopkins University, Baltimore · Dana-Farber Cancer Institute, Boston · University of Texas - MD Anderson Cancer Center, Houston · Cedars-Sinai Medical Center, Los Angeles · University of California, Los Angeles, Los Angeles · Memorial Sloan-Kettering Cancer Center, New York · Childrens Hospital of Philadelphia, Philadelphia · University of Pittsburgh Medical Center Childrens Hospital of Pittsburgh, Pittsburgh · Mayo Clinic Childrens Center, Rochester

  Registry updated 2026-10-29

• NCT07516353

  my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults

  Trial Treatment · Dana-Farber Cancer Institute

  Dana-Farber Cancer Institute, Boston

  Registry updated 2026-10-29

• NCT01793168

  Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

  Research · Sanford Health

  Sanford Health, Sioux Falls

  Registry updated 2026-10-28

• NCT04557449

  Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors

  Trial Treatment · Phase 1/2 · Pfizer

  Dana-Farber Cancer Institute, Boston · Brigham & Women's Hospital, Boston · START | Midwest, Grand Rapids · The University of Texas, MD Anderson Cancer Center - West Houston, Houston · The University of Texas MD Anderson Cancer Center, Houston · Ellison Institute, Los Angeles · Sarah Cannon Research Institute- Pharmacy, Nashville · SCRI Oncology Partners, Nashville · Smilow Cancer Hospital - Yale New Haven Health, New Haven · Smilow Cancer Hospital Phase 1 Unit, New Haven · Yale - New Haven Hospital - Yale Cancer Center, New Haven · Yale University - Smilow Cancer Hospital; C/O Thomas Ferencz, RPh, BCOP, New Haven · Dana-Farber Cancer Institute - Chestnut Hill, Newton · Smilow Cancer Hospital - Trumbull, Trumbull

  Registry updated 2026-10-28

• NCT04616560

  Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor

  Trial Treatment · Phase 2 · National Cancer Institute (NCI)

  C S Mott Children's Hospital, Ann Arbor · Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta · Children's Hospital Colorado, Aurora · Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore · Children's Hospital of Alabama, Birmingham · Dana-Farber Cancer Institute, Boston · University of Chicago Comprehensive Cancer Center, Chicago · Lurie Children's Hospital-Chicago, Chicago · Cincinnati Children's Hospital Medical Center, Cincinnati · UT Southwestern/Simmons Cancer Center-Dallas, Dallas · Duke University Medical Center, Durham · Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston · Riley Hospital for Children, Indianapolis · Children's Mercy Hospitals and Clinics, Kansas City · Children's Hospital Los Angeles, Los Angeles · Saint Jude Children's Research Hospital, Memphis · University of Minnesota/Masonic Cancer Center, Minneapolis · Vanderbilt University/Ingram Cancer Center, Nashville · NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York · Memorial Sloan-Kettering Cancer Center, New York · Children's Hospital of Orange County, Orange · Lucile Packard Children's Hospital Stanford University, Palo Alto · Children's Hospital of Philadelphia, Philadelphia · Children's Hospital of Pittsburgh of UPMC, Pittsburgh · Oregon Health and Science University, Portland · Primary Children's Hospital, Salt Lake City · UCSF Medical Center-Mission Bay, San Francisco · Seattle Children's Hospital, Seattle · Washington University School of Medicine, St Louis · Johns Hopkins All Children's Hospital, St. Petersburg · New York Medical College, Valhalla · Children's National Medical Center, Washington D.C.

  Registry updated 2026-10-28

• NCT06242470

  A Study of MGC026 in Participants With Advanced Solid Tumors

  Trial Treatment · Phase 1 · MacroGenics

  START | Midwest, Grand Rapids · University of Texas Health Science Center at Houston, Houston · The University of Texas MD Anderson Cancer Center, Houston · START New York Long Island, Lake Success · The Angeles Clinic and Research Institute, Los Angeles · Providence Cancer Institute, Portland · START Mountain Region, West Valley City

  Registry updated 2026-10-28

• NCT06710756

  Lead-212 PSV359 Therapy for Patients With Solid Tumors

  Trial Treatment · Phase 1/2 · Perspective Therapeutics

  Cleveland Clinic, Cleveland · Ohio State University, Columbus · UT Southwestern University Hospital Radiology Clinic, Dallas · MD Anderson Cancer Center, Houston · University of Kansas, Kansas City · University of Kentucky, Lexington · VA Greater Los Angeles Healthcare System, Los Angeles · UCLA Department of Medicine - Hematology/Oncology, Los Angeles · University of Wisconsin, Madison · Biogenix, Miami · University of Miami, Miami · Memorial Sloan Kettering Cancer Center - Main Campus, New York · Nebraska Cancer Specialists, Omaha · University of Pittsburgh Medical Center, Pittsburgh · Mayo Clinic in Rochester, Minnesota, Rochester · Saint Louis University, St Louis

  Registry updated 2026-10-28

• NCT02508038

  Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

  Trial Treatment · Phase 1 · University of Wisconsin, Madison

  University of Wisconsin Carbone Cancer Center, Madison

  Registry updated 2026-10-27

• NCT06441331

  Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors

  Trial Treatment · Phase 1 · ITM Solucin GmbH

  Cincinnati Children's Hospital Medical Center, Cincinnati · University of Texas - MD Anderson Cancer Center, Houston · Lucile Packard Children's Hospital at Stanford, Palo Alto · The Children's Hospital of Philadelphia (CHOP), Philadelphia · UCSF Benioff Children's Hospital, San Francisco

  Registry updated 2026-10-27

• NCT07197554

  A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

  Trial Treatment · Phase 1 · SEED Therapeutics, Inc.

  Mass General Brigham Cancer Institute, Boston · Dana-Farber Cancer Institute, Boston · The City of Hope National Medical Center, Duarte · The University of Texas MD Anderson Cancer Center, Houston · Hoag Memorial Hospital, Newport Beach · Memorial Sloan-Kettering Cancer Center, New York

  Registry updated 2026-10-27

• NCT03382158

  International PPB/DICER1 Registry

  Research · Children's Hospitals and Clinics of Minnesota

  Children's Minnesota, Minneapolis

  Registry updated 2026-10-26

All Sarcoma trials and the map

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