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Sarcoma: open trials in United States

302 open trials have a site in United States. Registry data; only the trial team decides who can take part.

  • NCT04303117

    PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

    Trial Treatment · Phase 1/2 · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT04902443

    Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

    Trial Treatment · Phase 1 · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT04941274

    Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma

    Trial Treatment · Phase 1/2 · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT04968288

    Natural History of KSHV-Associated Multicentric Castleman s Disease

    Research · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT05907759

    Daratumumab for Relapsed/Refractory Primary Effusion Lymphoma, Plasmablastic Lymphoma, and Multicentric Castleman Disease

    Trial Treatment · Phase 2 · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT06052618

    Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)

    Trial Treatment · Phase 2 · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT06066138

    A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

    Trial Treatment · Phase 1 · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT06865664

    FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma

    Trial Treatment · Phase 1 · National Cancer Institute (NCI)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-16

  • NCT07650656

    Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial

    Trial Treatment · Phase 2 · City of Hope Medical Center

    City of Hope Medical Center, Duarte

    Registry updated 2026-10-16

  • NCT07458347

    A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

    Trial Treatment · Phase 1 · Kestrel Therapeutics, Inc.

    Mass General Brigham Cancer Institute at Massachusetts General Hospital, Boston · NEXT Virginia, Fairfax · The University of Texas MD Anderson Cancer Center, Houston · Cedars-Sinai Medical Center, Los Angeles · Sidney Kimmel Cancer Center, Philadelphia · Huntsman Cancer Institute/University of Utah, Salt Lake City · NEXT Oncology, San Antonio · Florida Cancer Specialists, Sarasota · Moffitt Cancer Center, Tampa

    Registry updated 2026-10-15

  • NCT06571734

    Registry updated 2026-10-13

  • NCT07541170

    A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

    Trial Treatment · Phase 3 · Hoffmann-La Roche

    Piedmont Cancer Institute, PC, Atlanta · Community Cancer Institute (CCI), Clovis · San Juan Oncology Associates, Farmington · Profound Research, LLC, Farmington Hills · Cancer Care Specialists, Reno · Renown Regional Medical Center, Reno

    Registry updated 2026-10-13

  • NCT07615049

    Testing Short-Course Radiation Versus Standard-Course Radiation for Soft Tissue Sarcomas That Need Surgery and Radiation

    Trial Treatment · Phase 3 · SWOG Cancer Research Network

    Kaiser Permanente-Anaheim, Anaheim · Kaiser Permanente-Deer Valley Medical Center, Antioch · Emory Saint Joseph's Hospital, Atlanta · Emory University Hospital Midtown, Atlanta · Grady Health System, Atlanta · Emory University Hospital/Winship Cancer Institute, Atlanta · Kaiser Permanente-Bellflower, Bellflower · Billings Clinic Cancer Center, Billings · University of Alabama at Birmingham Cancer Center, Birmingham · Roswell Park Cancer Institute, Buffalo · Christiana Care Health System-Concord Health Center, Chadds Ford · Cancer Care Specialists of Illinois - Decatur, Decatur · Decatur Memorial Hospital, Decatur · Kaiser Permanente Dublin, Dublin · Kaiser Permanente-Fremont, Fremont · Kaiser Permanente-Fresno, Fresno · Fresno Cancer Center, Fresno · Kaiser Permanente Fresno Orchard Plaza, Fresno · UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine · Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon · Geisinger Medical Oncology-Lewisburg, Lewisburg · Kaiser Permanente Los Angeles Medical Center, Los Angeles · USC / Norris Comprehensive Cancer Center, Los Angeles · Dartmouth Cancer Center - Manchester/ DCC Manchester, Manchester · Marshfield Medical Center-Marshfield, Marshfield · Froedtert Menomonee Falls Hospital, Menomonee Falls · Medical College of Wisconsin, Milwaukee · Kaiser Permanente- Modesto MOB II, Modesto · Helen F Graham Cancer Center, Newark · Medical Oncology Hematology Consultants PA, Newark · Christiana Care Health System-Christiana Hospital, Newark · Froedtert and MCW Moorland Reserve Health Center, New Berlin · Drexel Town Square Health Center, Oak Creek · Kaiser Permanente-Oakland, Oakland · Kaiser Permanente Oakland-Broadway, Oakland · Kaiser Permanente-Ontario, Ontario · UC Irvine Health- Chao Family Comprehensive Cancer Center, Orange · Thomas Jefferson University Hospital, Philadelphia · Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova · Kaiser Permanente- Marshall Medical Offices, Redwood City · VCU Massey Comprehensive Cancer Center, Richmond · Kaiser Permanente-Richmond, Richmond · Rohnert Park Cancer Center, Rohnert Park · Kaiser Permanente-Roseville, Roseville · The Permanente Medical Group-Roseville Radiation Oncology, Roseville · South Sacramento Cancer Center, Sacramento · Kaiser Permanente-South Sacramento, Sacramento · Kaiser Permanente Downtown Commons, Sacramento · Dartmouth Cancer Center - North, Saint Johnsbury · Kaiser Permanente-San Francisco, San Francisco · Kaiser Permanente-Santa Teresa-San Jose, San Jose · Kaiser Permanente San Leandro, San Leandro · Kaiser San Rafael-Gallinas, San Rafael · Kaiser Permanente Medical Center - Santa Clara, Santa Clara · Kaiser Permanente-Santa Rosa, Santa Rosa · Kaiser Permanente Cancer Treatment Center, South San Francisco · Kaiser Permanente-South San Francisco, South San Francisco · Kaiser Permanente-Stockton, Stockton · Montefiore Medical Center-Weiler Hospital, The Bronx · Montefiore Medical Center - Moses Campus, The Bronx · Montefiore Medical Center-Einstein Campus, The Bronx · Kaiser Permanente Medical Center-Vacaville, Vacaville · Kaiser Permanente-Vallejo, Vallejo · Kaiser Permanente-Walnut Creek, Walnut Creek · Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend · Marshfield Medical Center - Weston, Weston · Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

    Registry updated 2026-10-13

  • NCT07851636

    Registry updated 2026-10-13

  • NCT02792270

    Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

    Trial Treatment · Massachusetts General Hospital

    Massachusetts General Hospital, Boston

    Registry updated 2026-10-09

  • NCT03244020

    LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

    Trial Treatment · Phase 4 · Massachusetts General Hospital

    Johns Hopkins University, Baltimore · Santiago Lozano-Calderon, Boston · Brigham and Women's Hospital, Boston · Beth Israel Deaconess Medical Center, Boston · Cooper University Health Care, Camden · Cleveland Clinic, Cleveland · University of Missouri-Columbia Cancer Care, Columbia · University of California Los Angeles Health, Los Angeles · Louisiana State University Health, New Orleans · Moffitt Cancer Center, Tampa

    Registry updated 2026-10-09

  • NCT07261631

    Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

    Trial Treatment · Phase 1 · Novartis Pharmaceuticals

    United Theranostics, Princeton

    Registry updated 2026-10-09

  • NCT07741877

    A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma

    Trial Treatment · Phase 2 · Iovance Biotherapeutics, Inc.

    Memorial Sloan-Kettering Cancer Center, New York · Moffitt Cancer Center, Tampa

    Registry updated 2026-10-09

  • NCT02013336

    Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid Tumors

    Trial Treatment · Phase 1 · South Plains Oncology Consortium

    Cincinnati Children's Hospital Medical Center, Cincinnati · UT Southwestern, Dallas · Texas Tech University Health Sciences Center, Lubbock · Midwest Children's Hospital, Milwaukee · University of Oklahoma Health Sciences Center, Oklahoma City

    Registry updated 2026-10-08

  • NCT04031677

    Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

    Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC

    University Of Michigan Comprehensive Cancer Center, Ann Arbor · Emory University Hospital Midtown, Atlanta · UCHealth University of Colorado Hospital, Aurora · Johns Hopkins Univ/Sidney Kimmel Cancer Center, Baltimore · Our Lady of the Lake Physician Group, Baton Rouge · LSU Health Baton Rouge-North Clinic, Baton Rouge · Our Lady of the Lake Hospital, Baton Rouge · Nebraska Medicine-Bellevue, Bellevue · Sanford Joe Lueken Cancer Center, Bemidji · University of Alabama at Birmingham Cancer Center, Birmingham · Sanford Bismarck Medical Center, Bismarck · Dana-Farber Harvard Cancer Center, Boston · Roswell Park Cancer Institute, Buffalo · University of Vermont Medical Center, Burlington · Vermont Regional Cancer Center, Burlington · Cooper Hospital University Medical Center, Camden · Carolinas Medical Center/Levine Cancer Institute, Charlotte · University of Illinois at Chicago MBCCOP, Chicago · Rush University Medical Center, Chicago · Northwestern University, Chicago · Ohio State University Comprehensive Cancer Center, Columbus · Siteman Cancer Center - West County, Creve Coeur · UT Southwestern/Simmons Cancer Center-Dallas, Dallas · Smilow Cancer Hospital-Derby Care Center, Derby · City of Hope Comprehensive Cancer Center, Duarte · Duke University Medical Center, Durham · Marshfield Medical Center-EC Cancer Center, Eau Claire · Saint Vincent Hospital, Erie · Smilow Cancer Hospital Care Center-Fairfield, Fairfield · Sanford Broadway Medical Center, Fargo · Sanford Roger Maris Cancer Center, Fargo · Univ of Florida Health Science Ctr - Gainesville, Gainesville · Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury · Smilow Cancer Hospital Care Center at Greenwich, Greenwich · Smilow Cancer Hospital Care Center - Guiford, Guilford · HMH-Hackensack University Medical Center, Hackensack · Smilow Cancer Hospital Care Ctr at Saint Francis, Hartford · M D Anderson Cancer Center, Houston · Indiana Univ/Melvin and Bren Simon Cancer Center, Indianapolis · UCI Health-Chao Family Comp CC and Ambulatory Care, Irvine · Mayo Clinic in Florida, Jacksonville · Jefferson Hospital, Jefferson Hills · University of Kansas Cancer Center, Kansas City · University of Tennessee - Knoxville, Knoxville · UC San Diego Moores Cancer Center, La Jolla · Northwell Health/Center for Advanced Medicine, Lake Success · Dartmouth Hitchcock Med Ctr/Dartmouth Cancer Ctr, Lebanon · James Graham Brown Ca Ctr at Univ of Louisville, Louisville · UofL Health Medical Center Northeast, Louisville · North Shore University Hospital, Manhasset · Marshfield Medical Center, Marshfield · VCU Massey Cancer Center at Hanover Medical Park, Mechanicsville · Froedtert Menomonee Falls Hospital, Menomonee Falls · Medical College of Wisconsin, Milwaukee · NYU Langone Hospital - Long Island, Mineola · Marshfield Medical Center, Minocqua · Forbes Hospital, Monroeville · Vanderbilt University/Ingram Cancer Center, Nashville · Allegheny Valley Hospital, Natrona Heights · Jersey Shore University Medical Center, Neptune City · Froedtert and MCW Moorland Reserve Health Center, New Berlin · Rutgers Cancer Institute of New Jersey, New Brunswick · Yale University, New Haven · Long Island Jewish Medical Center, New Hyde Park · Laura and Issac Perlmutter Ca Ctr at NYU Langone, New York · Yale-New Haven Hospital North Haven Medical Center, North Haven · Drexel Town Square Health Center, Oak Creek · University of Oklahoma Health Sciences Center, Oklahoma City · Nebraska Medicine-Bellevue, Omaha · University of Nebraska Medical Center, Omaha · UC Irvine Health/Chao Family Comprehensive Ca Ctr, Orange · University of Kansas Cancer Center-Overland Park, Overland Park · John Theurer Cancer Center at From Road, Paramus · University of Pennsylvania/Abramson Cancer Center, Philadelphia · Fox Chase Cancer Center, Philadelphia · Pennsylvania Hospital, Philadelphia · Thomas Jefferson University Hospital, Philadelphia · Mayo Clinic Hospital in Arizona, Phoenix · Allegheny General Hospital, Pittsburgh · UPMC Hillman Cancer Center, Pittsburgh · West Penn Hospital, Pittsburgh · Oregon Health and Science University, Portland · Rhode Island Hospital, Providence · Renown Regional Medical Center, Reno · Marshfield Medical Center, Rice Lake · VCU Massey Cancer Center at Stony Point, Richmond · Virginia Commonwealth Univ/Massey Cancer Center, Richmond · Carilion Roanoke Memorial Hospital, Roanoke · Mayo Clinic, Rochester · University of Rochester, Rochester · Huntsman Cancer Institute/University of Utah, Salt Lake City · FHCC South Lake Union, Seattle · University of Washington Medical Center - Montlake, Seattle · Fred Hutchinson Cancer Center, Seattle · Sanford Cancer Center Oncology Clinic, Sioux Falls · Sanford USD Medical Center - Sioux Falls, Sioux Falls · VCU Community Memorial Health Center, South Hill · Smilow Cancer Hospital Care Center at Long Ridge, Stamford · Marshfield Med Ctr-River Region at Stevens Point, Stevens Point · Washington University School of Medicine - Siteman Cancer Center, St Louis · Siteman Cancer Center-South Country, St Louis · Stony Brook University Medical Center, Stony Brook · Moffitt Cancer Center, Tampa · Moffitt Cancer Center - McKinley Campus, Tampa · Moffitt Cancer Center-International Plaza, Tampa · Montefiore Medical Center - Moses Campus, The Bronx · Montefiore Medical Center-Einstein Campus, The Bronx · Smilow Cancer Hospital Care Center-Trumbull, Trumbull · Smilow Cancer Hospital-Waterbury Care Center, Waterbury · Smilow Cancer Hospital Care Center - Waterford, Waterford · Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend · Smilow Cancer Hospital Care Center - Westerly, Westerly · Marshfield Medical Center, Weston · University of Kansas Hospital-Westwood Cancer Ctr, Westwood · Wexford Health and Wellness Pavilion, Wexford · Midwestern Regional Medical Center, Zion

    Registry updated 2026-10-07

  • NCT05588648

    Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults With Recurrent, Refractory or Progressive Osteosarcoma

    Trial Treatment · Phase 1/2 · MedPacto, Inc.

    UH Rainbow Babies & Children's Hospital, Cleveland

    Registry updated 2026-10-07

  • NCT05019703

    Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study

    Trial Treatment · Phase 2 · M.D. Anderson Cancer Center

    Dana-Farber Cancer Institute, Boston · M D Anderson Cancer Center, Houston

    Registry updated 2026-10-06

  • NCT05039801

    IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

    Trial Treatment · Phase 1 · M.D. Anderson Cancer Center

    M D Anderson Cancer Center, Houston

    Registry updated 2026-10-06

  • NCT06541262

    Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

    Trial Treatment · Phase 1/2 · Milton S. Hershey Medical Center

    University of Alabama/Children's of Alabama, Birmingham · Children's Medical Center, Dallas · Children's Hospital of Michigan/Wayne State University, Detroit · University of Florida, Gainesville · Hackensack University Medical Center, Hackensack · Connecticut Children's Hospital, Hartford · Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey · Kapiolani Medical Center for Women and Children, Honolulu · Children's Mercy Hospitals and Clinics, Kansas City · Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine, Louisville · Nicklaus Children's Hospital, Miami · Monroe Carrell Jr. Children's Hospital at Vanderbilt, Nashville · UCSF Benioff Children's Hospital Oakland, Oakland · Arnold Palmer Hospital for Children, Orlando · Phoenix Children s Hospital, Phoenix · Hasbro Children's Hospital, Providence · Virginia Commonwealth University, Richmond · UC Davis Comprehensive Cancer Center, Sacramento · Primary Children's Hospital, Salt Lake City · Rady Children's Hospital, San Diego · Cardinal Glennon Children's Medical Center, St Louis · All Children's Hospital Johns Hopkins Medicine, St. Petersburg · St. Joseph's Children's Hospital, Tampa

    Registry updated 2026-10-06

  • NCT06721689

    PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

    Trial Treatment · Phase 1/2 · Theodore Laetsch

    Dana-Farber Cancer Institute, Boston · Boston Children's Hospital, Boston · Texas Children's Hospital, Houston · Cedars-Sinai Medical Center, Los Angeles · Children's Hospital of Philadelphia, Philadelphia · University of Utah Hospital, Salt Lake City · University of California San Francisco, San Francisco

    Registry updated 2026-10-06

All Sarcoma trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

Sarcoma trials in United States – Frontlight Research