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Sarcoma: open trials in United States

301 open trials have a site in United States. Registry data; only the trial team decides who can take part.

  • NCT06541262

    Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

    Trial Treatment · Phase 1/2 · Milton S. Hershey Medical Center

    University of Alabama/Children's of Alabama, Birmingham · Children's Medical Center, Dallas · Children's Hospital of Michigan/Wayne State University, Detroit · University of Florida, Gainesville · Hackensack University Medical Center, Hackensack · Connecticut Children's Hospital, Hartford · Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey · Kapiolani Medical Center for Women and Children, Honolulu · Children's Mercy Hospitals and Clinics, Kansas City · Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine, Louisville · Nicklaus Children's Hospital, Miami · Monroe Carrell Jr. Children's Hospital at Vanderbilt, Nashville · UCSF Benioff Children's Hospital Oakland, Oakland · Arnold Palmer Hospital for Children, Orlando · Phoenix Children s Hospital, Phoenix · Hasbro Children's Hospital, Providence · Virginia Commonwealth University, Richmond · UC Davis Comprehensive Cancer Center, Sacramento · Primary Children's Hospital, Salt Lake City · Rady Children's Hospital, San Diego · Cardinal Glennon Children's Medical Center, St Louis · All Children's Hospital Johns Hopkins Medicine, St. Petersburg · St. Joseph's Children's Hospital, Tampa

    Registry updated 2026-10-06

  • NCT06721689

    PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

    Trial Treatment · Phase 1/2 · Theodore Laetsch

    Dana-Farber Cancer Institute, Boston · Boston Children's Hospital, Boston · Texas Children's Hospital, Houston · Cedars-Sinai Medical Center, Los Angeles · Children's Hospital of Philadelphia, Philadelphia · University of Utah Hospital, Salt Lake City · University of California San Francisco, San Francisco

    Registry updated 2026-10-06

  • NCT07188532

    Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial

    Trial Treatment · Mayo Clinic

    Mayo Clinic in Arizona, Phoenix · Mayo Clinic in Rochester, Rochester

    Registry updated 2026-10-06

  • NCT07321912

    Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

    Trial Treatment · Phase 2 · Milton S. Hershey Medical Center

    Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey · Randall Children's Hospital, Portland · St. Joseph's Children's Hospital, Tampa

    Registry updated 2026-10-06

  • NCT06840886

    A Study of PHST001 in Advanced Solid Tumors

    Trial Treatment · Phase 1 · Pheast Therapeutics

    University of Michigan Rogel Cancer Center, Ann Arbor · Precision NextGen Oncology & Research Center, Beverly Hills · Dana-Farber Cancer Institute, Boston · University of Chicago Medical Center, Chicago · Sarah Cannon Research Institute (SCRI) Oncology Partners - Denver Health One, Denver · Duke Cancer Institute, Durham · NEXT Oncology- Virginia, Fairfax · START Center for Cancer Research - Texas, Fort Worth · START Center for Cancer Research - Midwest, Grand Rapids · MD Anderson Cancer Center, Houston · Next Oncology Dallas, Irving · START Center for Cancer Research - Long Island New York, Lake Success · USC / Norris Comprehensive Cancer Center, Los Angeles · Sarah Cannon Research Institute (SCRI) Oncology Partners, Nashville · Vanderbilt-Ingram Cancer Center, Nashville · Yale Cancer Center, New Haven · Mount Sinai, New York · Stanford University, School of Medicine, Palo Alto · START Center for Cancer Research - San Antonio, San Antonio · University of Texas (UT) Health, San Antonio

    Registry updated 2026-10-05

  • NCT06528769

    Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma

    Trial Treatment · Phase 2 · Gabriel Tinoco

    Ohio State University Comprehensive Cancer Center, Columbus

    Registry updated 2026-10-01

  • NCT06749366

    Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing

    Research · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    National Institutes of Health Clinical Center, Bethesda

    Registry updated 2026-10-01

  • NCT07189871

    177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors

    Trial Treatment · Phase 1/2 · Radiopharm Theranostics, Ltd

    Dothan Hematology & Oncology, Dothan · BAMF Health, Grand Rapids · MD Anderson Cancer Center, Houston · XCancer, Omaha · Nebraska Cancer Specialists, Omaha

    Registry updated 2026-10-01

  • NCT07602777

    Registry updated 2026-10-01

  • NCT06492954

    Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma

    Trial Treatment · Phase 1 · Emory University

    Chilldren's Healthcare of Atlanta, Atlanta

    Registry updated 2026-09-30

  • NCT06881992

    A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

    Trial Treatment · Phase 3 · Rezolute

    Bethesda · Boston · Canton · Chicago · Houston · New York · Portland · Rochester

    Registry updated 2026-09-28

  • NCT06884618

    A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

    Trial Treatment · Phase 1 · Hoffmann-La Roche

    UCHealth Lung Cancer Clinic - Anschutz Medical Campus - PPDS, Aurora · City of Hope Comprehensive Cancer Center, Duarte · MD Anderson Cancer Center, Houston · Smilow Cancer Hospital at Yale - New Haven, New Haven · South Texas Accelerated Research Therapeutics (START), San Antonio · Florida Cancer Specialists - Sarasota (North Catttlemen Rd), Sarasota

    Registry updated 2026-09-28

  • NCT04094610

    A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

    Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.

    Children's Healthcare of Atlanta - Egleston Hospital, Atlanta · Children's Hospital Colorado - Anschutz Medical Campus, Aurora · Dana-Farber Cancer Institute, Boston · Levine Children's Hospital- Pediatric Neuro-Oncology, Charlotte · Cleveland · The University of Texas Southwestern Medical Center - Harold C Simmons Comprehensive Cancer Center, Dallas · Hershey · Houston · Baylor College of Medicine, Houston · Children's Hospital Los Angeles, Los Angeles · University of California at Los Angeles, Los Angeles · St. Jude Children's Research Hospital, Memphis · New Brunswick · New York · Orlando · Orlando · Children's Hospital of Philadelphia-Center for Childhood Cancer Research, Philadelphia · Children's Hospital of Richmond at VCU, Richmond · Maine Medical Center, Scarborough · Washington University School of Medicine in St. Louis, St Louis

    Registry updated 2026-09-25

  • NCT07124000

    DESTINY-PANTUMOUR04

    Research · AstraZeneca

    Birmingham · Boulder · Bullhead City · Canton · Casa Grande · Coral Springs · Dallas · Decatur · Durham · Farmington · Maumee · Nashville · Philadelphia · San Diego · St. Petersburg · Topeka · West Palm Beach · Wilson

    Registry updated 2026-09-25

  • NCT07193550

    A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)

    Trial Treatment · Phase 2 · M.D. Anderson Cancer Center

    The University of Texas M. D. Anderson Cancer Center, Houston

    Registry updated 2026-09-25

  • NCT07194044

    Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

    Trial Treatment · Phase 1 · H. Lee Moffitt Cancer Center and Research Institute

    Children's Healthcare of Atlanta - Arthur M Blank Hospital (AMBH), Atlanta · University of Alabama at Birmingham, Children's of Alabama, Birmingham · Roswell Park Comprehensive Cancer Center, Buffalo · University of North Carolina, Chapel Hill · Levine Cancer Institute, Charlotte · Cleveland Clinic Children's, Cleveland · Nationwide Children's Hospital, Columbus · Duke University Medical Center- Children's Health Center, Durham · University of Florida, Gainesville · Helen DeVos Children's Hospital, Grand Rapids · Connecticut Children's Medical Center, Hartford · Nemours Jacksonville, Jacksonville · University of Kentucky, Lexington · University of Miami, Miami · Vanderbilt University Medical Center, Nashville · Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville · Phoenix Children s Hospital, Phoenix · Primary Children's Hospital, Salt Lake City · Johns Hopkins All Children's Hospital, St. Petersburg · Moffitt Cancer Center, Tampa · Montefiore Medical Center, The Bronx

    Registry updated 2026-09-25

  • NCT07229313

    A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors

    Trial Treatment · Phase 1 · Kivu Bioscience Inc.

    New Have · Santa Monica

    Registry updated 2026-09-24

  • NCT06610682

    A Trial to Evaluate CSF ctDNA and Safety of Plixorafenib Alone or With Retifanlimab in Patients With BRAF-altered Glioma

    Trial Treatment · Early phase 1 · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Johns Hopkins, Baltimore · NYU Langone Health Perlmutter Cancer Center Ambulatory Care Center, New York

    Registry updated 2026-09-22

  • NCT06021626

    A Study of CRD3874-SI in People With Solid Tumors

    Trial Treatment · Phase 1 · Memorial Sloan Kettering Cancer Center

    Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge · Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities), Commack · Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison · Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (Limited Protocol Activities), Rockville Centre

    Registry updated 2026-09-21

  • NCT07629960

    A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

    Trial Treatment · Phase 1/2 · Blueprint Medicines Corporation

    University of Michigan Medical School Rogel Cancer Center, Ann Arbor · Mary Bird Perkins Cancer Center, Baton Rouge · Massachusetts General Hospital - Main Campus, Boston · Next Oncology Virginia Cancer Specialist, Fairfax · Hackensack University Medical Center, Hackensack · The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston · Tennessee Oncology, PLLC, Nashville · NYU Langone Health Perlmutter Cancer Center, New York · Florida Cancer Specialists & Research Institute - Sarasota, Sarasota · Moffitt Cancer Center, Tampa

    Registry updated 2026-09-21

  • NCT07298083

    DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical Margins

    Research · M.D. Anderson Cancer Center

    The University of Texas M. D. Anderson Cancer Center, Houston

    Registry updated 2026-09-18

  • NCT06025747

    A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas

    Trial Treatment · Phase 1 · University of Washington

    Fred Hutch/University of Washington Cancer Consortium, Seattle

    Registry updated 2026-09-17

  • NCT07695311

    EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT

    Trial Treatment · Phase 1 · Rabi Hanna

    Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute, Cleveland

    Registry updated 2026-09-17

  • NCT06843967

    A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

    Trial Treatment · Phase 1/2 · Memorial Sloan Kettering Cancer Center

    Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge · Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited Protocol Activities), Commack · Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison · Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale

    Registry updated 2026-09-16

  • NCT07823491

    Registry updated 2026-09-16

All Sarcoma trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.