Sarcoma: open trials in United States

301 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT05607095
A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, Dedifferentiated Liposarcoma, or Angiosarcoma
Trial Treatment · Phase 1 · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Westchester, Harrison · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York
Registry updated 2026-09-15
NCT04751409
Evaluating the Impact of Limited Compared With Intense Post-Operative Surveillance on Patient-Reported Outcomes in Patients With Stage II-III Soft Tissue Sarcoma of the Trunk and Extremities
Trial Treatment · Phase 2 · M.D. Anderson Cancer Center
M D Anderson Cancer Center, Houston
Registry updated 2026-09-14
NCT06674811
Biomarkers of Resiliency In Childhood Cancer Surgery
Research · Mayo Clinic
Mayo Clinic, Rochester
Registry updated 2026-09-14
NCT06797999
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
Trial Treatment · Phase 1/2 · Adcendo ApS
University of Colorado Denver, Aurora · University of Texas - MD Anderson Cancer Center, Houston · University of Miami - Sylvester Comprehensive Cancer Center, Miami · Memorial Sloan-Kettering Cancer Center, New York
Registry updated 2026-09-11
NCT07215611
Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas
Research · M.D. Anderson Cancer Center
MD Anderson Cancer Center, Houston
Registry updated 2026-09-11
NCT07811232
A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers
Trial Treatment · Phase 1/2 · Advenchen Pharmaceuticals, LLC.
The University of Texas MD Anderson Cancer Center, Houston
Registry updated 2026-09-10
NCT07811297
A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM Cancers
Trial Treatment · Phase 1/2 · Advenchen Pharmaceuticals, LLC.
The University of Texas MD Anderson Cancer Center, Houston
Registry updated 2026-09-10
NCT06440005
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1 · Angiex, Inc.
NEXT Oncology, Fairfax · UT MD Anderson, Houston · USC / Norris Comprehensive Cancer Center, Los Angeles · Sarah Cannon Research Center, Nashville · NEXT Oncology, San Antonio · Florida Cancer Specialist, Sarasota · Washington University School of Medicine, St Louis
Registry updated 2026-09-09
NCT06578624
Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors
Trial Treatment · Phase 1/2 · Lamassu Bio Inc
Gabrail Cancer Center, Canton · University Hospitals Cleveland Medical Center*, Cleveland · Cleveland Clinic Taussig Cancer Institute, Cleveland
Registry updated 2026-09-09
NCT03715933
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Trial Treatment · Phase 1 · Inhibrx Biosciences, Inc
University of Michigan, Ann Arbor · Emory University/Winship Cancer Institute, Atlanta · University of Colorado Hospital, Aurora · Precision NextGen Oncology and Research, Beverly Hills · University of Virginia, Charlottesville · The University Of Chicago, Chicago · Cincinnati Children's Hospital Medical Center, Cincinnati · Cleveland Clinic, Cleveland · City of Hope, Duarte · NEXT Oncology- Virginia, Fairfax · START Midwest Michigan, PC, Grand Rapids · UT MD Anderson Cancer Center, Houston · Valkyrie Clinical Trials, Los Angeles · Vanderbilt University School of Medicine, Nashville · David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York · Children's Hospital of Orange County-Rady Children's Health, Orange · Children's Hospital of Philadelphia-Center for Childhood Cancer Research, Philadelphia · University of Pennsylvania/Abramson Cancer Center, Philadelphia · Oregon Health Science University, Portland · NEXT Oncology, San Antonio · University of California, San Diego (UCSD) - Moores Cancer Center, San Diego · University of California, San Francisco (UCSF), San Francisco · Sarcoma Oncology Center, Santa Monica · HonorHealth Research Institute, Scottsdale
Registry updated 2026-09-08
NCT04577014
Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma
Trial Treatment · Phase 1/2 · Memorial Sloan Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center, New York
Registry updated 2026-09-08
NCT05732831
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors
Trial Treatment · Phase 1/2 · Tango Therapeutics, Inc.
Dana-Farber Cancer Institute, Boston · Massachusetts General Hospital, Boston · University Chicago Medicine, Chicago · Henry Ford Cancer Center, Detroit · NEXT Oncology- Virginia, Fairfax · Grand Valley Oncology, Grand Junction · The University of Texas MD Anderson Cancer Center, Houston · Florida Cancer Specialists & Research Institute, Lake Mary · Sylvester Comprehensive Cancer Center*, Miami · Sarah Cannon - Tennessee Oncology, Nashville · New York University Langone Health, New York · Stanford University, Palo Alto · Huntsman Cancer Institute/University of Utah, Salt Lake City · Carle Cancer Center, Urbana · Midwestern Regional Medical Center, City of Hope Chicago, Zion
Registry updated 2026-09-08
NCT06644755
First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors
Trial Treatment · Phase 1 · Daiichi Sankyo
Dana-Farber Cancer Institute, Boston · Sarah Cannon Research Institute, Nashville · David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York
Registry updated 2026-09-04
NCT00411060
Clinical Orthopaedic Data Bank (Acute and Chronic)
Research · University of Florida
UF&Shands Orthopaedics and Sports Medicine Institute, Gainesville
Registry updated 2026-09-03
NCT06073067
GRID Therapy for Extremity Soft Tissue Sarcoma
Trial Treatment · UNC Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill
Registry updated 2026-09-03
NCT06156410
Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas
Trial Treatment · Phase 1 · Children's Hospital of Philadelphia
Children's Hospital Colorado, Aurora · University of Pennsylvania, Philadelphia · Children's Hospital of Philadelphia, Philadelphia · University of California San Francisco, San Francisco
Registry updated 2026-09-03
NCT06465199
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Trial Treatment · Phase 1/2 · Milton S. Hershey Medical Center
University of Alabama/Children's of Alabama, Birmingham · Children's Medical Center, Dallas · University of Florida, Gainesville · Hackensack University Medical Center, Hackensack · Connecticut Children's Hospital, Hartford · Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey · Kapiolani Medical Center for Women and Children, Honolulu · Children's Mercy Hospitals and Clinics, Kansas City · Arkansas Children's Hospital, Little Rock · Nicklaus Children's Hospital, Miami · Monroe Carrell Jr. Children's Hospital at Vanderbilt, Nashville · Arnold Palmer Hospital for Children, Orlando · Cardinal Glennon Children's Medical Center, St Louis · St. Joseph's Children's Hospital, Tampa
Registry updated 2026-09-03
NCT07725380
Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma
Trial Treatment · Phase 1/2 · H. Lee Moffitt Cancer Center and Research Institute
Nationwide Children's Hospital, Columbus · Washington University in St. Louis, St Louis · Moffitt Cancer Center, Tampa · Montefiore Medical Center, The Bronx
Registry updated 2026-09-03
NCT04188535
Serial MRI Scans During Radiation Therapy
Trial Treatment · Dana-Farber Cancer Institute
Dana-Farber Cancer Institute, Boston · Brigham and Women Hospital, Boston
Registry updated 2026-09-02
NCT05245500
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
Trial Treatment · Phase 1 · Bristol-Myers Squibb
Dana-Farber Cancer Institute, Brookline · University of North Carolina - Gastroenterology and Hepatology, Chapel Hill · University of North Carolina, Chapel Hill · Chicago · UT Southwestern, Dallas · Virginia Cancer Specialists PC, Fairfax · Texas Oncology - DFW, Fort Worth · The Cancer & Hematology Centers, Grand Rapids · MDACC, Houston · Mayo Clinic, Jacksonville · Rocky Mountain Cancer Centers, LLP - Oncology, Lone Tree · Milwaukee · Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola · Vanderbilt-Ingram Cancer Center, Nashville · Rutgers Cancer Institute of New Jersey, New Brunswick · David H Koch, Memorial Sloan Kettering Cancer Center, New York · Cancer and Hematology Centers of Western Michigan, Norton Shores · Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando · Mayo Clinic, Phoenix · New york cancer and blood specialists - Oncology, Port Jefferson Station · Mayo Clinic, Rochester · South Texas Accelerated Research Therapeutics, San Antonio · Seattle · Texas Oncology, P.A. - Oncology, Tyler
Registry updated 2026-09-02
NCT05837767
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue
Trial Treatment · Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge · Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities), Commack · Memorial Sloan Kettering Westchester (All Protocol Activities), Harrison · Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown · Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale · Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York · Memorial Sloan Kettering Nassau (Limited Protocol Activities), Rockville Centre
Registry updated 2026-09-02
NCT05918640
Lurbinectedin in FET-Fused Tumors
Trial Treatment · Phase 1/2 · Children's Hospital of Philadelphia
University of Michigan, Ann Arbor · Dana-Farber Cancer Institute, Boston · University of Iowa Hospitals and Clinics, Iowa City · Cedars-Sinai Medical Center, Los Angeles · Memorial Sloan-Kettering Cancer Center, New York · Children's Hospital of Philadelphia, Philadelphia
Registry updated 2026-09-02
NCT07252739
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Trial Treatment · Phase 2 · Merck Sharp & Dohme LLC
Clermont Oncology Center (Site 0041), Clermont · Sanford Health Roger Maris Cancer Center (Site 0039), Fargo · Sanford Cancer Center Oncology Clinic (Site 0038), Sioux Falls
Registry updated 2026-09-02
NCT03900793
Losartan + Sunitinib in Treatment of Osteosarcoma
Trial Treatment · Phase 1 · University of Colorado, Denver
Children's Hospital of Atlanta, Atlanta · Children's Hospital Colorado, Aurora · University of Colorado Hospital, Aurora · Children's Hospital Los Angeles, Los Angeles
Registry updated 2026-09-01
NCT06898970
Intratumoral Vusolimogene Oderparepvec (VO) in Combination With Pembrolizumab for Angiosarcoma
Trial Treatment · Phase 2 · Varun Monga, MBBS
University of California San Francisco, San Francisco
Registry updated 2026-09-01

All Sarcoma trials and the map

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