Sickle cell disease: open trials in Canada

14 open trials have a site in Canada. Registry data; only the trial team decides who can take part.

NCT07282210
Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype
Trial Treatment · Phase 2 · Biossil Inc.
McGill University Health Centre, Montreal · Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal · The Hospital for Sick Children, Toronto · University Health Network, Toronto General Hospital, Toronto
Registry updated 2026-11-02
NCT05777993
A Study to Provide Access to Mitapivat for Participants Who Previously Participated in an Agios-Sponsored Mitapivat Study
Trial Treatment · Phase 4 · Agios Pharmaceuticals, Inc.
McMaster Centre for Transfusion Medicine McMaster University, Hamilton · University Health Network, Toronto
Registry updated 2026-10-28
NCT06198712
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
Trial Treatment · Phase 2 · Forma Therapeutics, Inc.
The Hospital for Sick Children, Toronto
Registry updated 2026-09-18
NCT06609226
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Trial Treatment · Phase 3 · Novo Nordisk A/S
CHU Ste-Justine, Montreal · University Health Network, Toronto General Hospital, Toronto · The Hospital for Sick Children, Toronto · St Pauls Hospital, Vancouver
Registry updated 2026-09-18
NCT06612268
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Trial Treatment · Phase 3 · Novo Nordisk A/S
Foothills Med Ctr-Univ Calgary, Calgary · University of Alberta Edmonton, Edmonton · Stollery Children'S Hospital, Edmonton · LHSC Victoria Hospital, London · Montreal Children's Hospital, Montreal · CHUM-Hosp de Univ Montreal, Montreal · Scarborough Health Network Research Institute (SHNRI), Scarborough Village · UHN-Toronto General Hospital, Toronto · University of Toronto, Toronto · St Pauls Hospital, Vancouver · BC Children ' s Hospital, Vancouver
Registry updated 2026-09-17
NCT06761560
Optimizing Hydroxyurea Dosage With Pharmakokinetic in Patients Suffering of Moderate to Severe Sickle Cell Anemia
Trial Treatment · Phase 2/3 · Yves Pastore
CHU Sainte-Justine, Montreal
Registry updated 2026-08-21
NCT06481306
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Trial Treatment · Phase 1/2 · Bristol-Myers Squibb
Vancouver
Registry updated 2026-08-18
NCT04208529
A Long-term Follow-up Study in Participants Who Received CTX001
Trial Treatment · Phase 3 · Vertex Pharmaceuticals Incorporated
Toronto General Hospital - Hematology, Toronto · Hospital for Sick Children - Hematology, Toronto · St. Paul's Hospital - Hematology, Vancouver
Registry updated 2026-08-11
NCT06941389
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
Research · University of Rochester
Alberta Children's Hospital (MRD-HCT), Calgary · Alberta Children's Hospital (NT-DMT), Calgary · Universite de Montreal / Ste Justine (MRD HCT), Montreal · The Hospital for Sick Children (MRD-HCT), Toronto · British Columbia Children's Hosptial (MRD HCT), Vancouver · HSC Winnipeg Children's Hospital/University of Manitoba (MRD-HCT), Winnipeg
Registry updated 2026-06-04
NCT03214354
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
Trial Treatment · Phase 2 · University of Calgary
Alberta Children's Hospital, Calgary
Registry updated 2026-05-01
NCT03587272
Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
Trial Treatment · Phase 2 · Robert Nickel
Alberta Children's Hospital, Calgary · The Hospital for Sick Children, Toronto
Registry updated 2026-03-10
NCT04432623
The BENeFiTS Trial in Beta Thalassemia Intermedia
Trial Treatment · Phase 1/2 · Phoenicia BioScience
University Health Network and Toronto General Hospital, Toronto
Registry updated 2025-08-15
NCT06363760
A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301
Research · Editas Medicine, Inc.
Ottawa Hospital Research Institute, Ottawa · Princess Margaret Cancer Centre - University Health Network, Toronto
Registry updated 2025-04-02
NCT06529042
SCRIPT: Sickle Cell Risk in Pregnancy Tool
Research · Mount Sinai Hospital, Canada
Centre Hospitalier de l'Université de Montréal, Montreal · Providence Health Care, Vancouver
Registry updated 2024-11-27

All Sickle cell disease trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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