Sickle cell disease: open trials in Italy

14 open trials have a site in Italy. Registry data; only the trial team decides who can take part.

NCT07224360
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
Trial Treatment · Phase 2 · CSL Behring
University Hospital Of Ferrara, Ferrara · IRCCS Istituto Giannina Gaslini, Genoa · Azienda Ospedaliero - Universitaria di Modena, Modena · Fondazione IRCCS San Gerardo dei Tintori, Monza · Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli, Naples · Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo · Ospedale Pediatrico Bambino Gesù, Rome · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-11-03
NCT07656415
A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
Trial Treatment · Phase 3 · Agios Pharmaceuticals, Inc.
Ente Ospedaliero Ospedali Galliera Di Genova, Genoa · Azienda Ospedaliero - Universitaria di Modena, Modena · Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli, Naples · Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo
Registry updated 2026-10-28
NCT06975865
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Trial Treatment · Phase 3 · Sanofi
Florence · Genoa · Milan · Naples · Orbassano · Palermo · Rome · Verona
Registry updated 2026-10-15
NCT06699849
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Trial Treatment · Phase 2 · CSL Behring
IRCCS Istituto Giannina Gaslini, Genoa · Azienda Ospedaliero - Universitaria di Modena, Modena · Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano · Azienda Ospedaliera di Padova, Padova · Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo · Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome · Ospedale Pediatrico Bambino Gesù, Rome · Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-10-08
2025-524464-38-00
A research study to evaluate how well etavopivat works in children with sickle cell disease
Trial Treatment · Phase 3 · Novo Nordisk A/S
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia · Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania, Catania · Azienda Ospedaliero - Universitaria di Modena, Modena · Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli, Naples · Azienda Ospedaliera di Padova, Padova · Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo
Registry updated 2026-09-28
NCT06609226
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Trial Treatment · Phase 3 · Novo Nordisk A/S
Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano · Azienda Ospedaliera di Padova, Padova · Fondazione IRCCS Policlinico San Matteo, Pavia
Registry updated 2026-09-18
NCT06612268
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Trial Treatment · Phase 3 · Novo Nordisk A/S
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia · ARNAS Garibaldi Di Catania, Catania · Azienda Ospedaliero - Universitaria di Modena, Modena · Fondazione IRCCS San Gerardo dei Tintori, Monza · Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli, Naples · Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano · Azienda Ospedaliera di Padova, Padova · Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-09-17
NCT05431088
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Trial Treatment · Phase 2/3 · Pfizer
Ente Ospedaliero Ospedali Galliera Di Genova, Genoa · Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli, Naples · Azienda Ospedaliera di Padova, Padova · Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Palermo · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-08-18
NCT06481306
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Trial Treatment · Phase 1/2 · Bristol-Myers Squibb
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan · Universita Degli Studi Di Padova, Padova · Centro Ricerche Cliniche di Verona s.r.l., Verona
Registry updated 2026-08-18
NCT04208529
A Long-term Follow-up Study in Participants Who Received CTX001
Trial Treatment · Phase 3 · Vertex Pharmaceuticals Incorporated
Bambino Gesu Childrens Hospital, Rome
Registry updated 2026-08-11
NCT04657822
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
Trial Treatment · Phase 4 · Novartis Pharmaceuticals
Azienda Ospedale Universita Padova, Padova
Registry updated 2026-06-08
NCT05477563
Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease
Trial Treatment · Phase 3 · Vertex Pharmaceuticals Incorporated
Ospedale Pediatrico Bambino Gesù, Rome
Registry updated 2026-03-23
2023-503247-34-00
A Phase 3 Study to Evaluate Efficacy and Safety of a Single Dose of Exa-cel in Subjects with Severe Sickle Cell Disease, βS/βC Genotype
Trial Treatment · Phase 3 · Vertex Pharmaceuticals Inc.
Bambino Gesu Childrens Hospital, Rome
Registry updated 2025-08-19
NCT05799118
Study of the Role of Genetic Modifiers in Hemoglobinopathies
Research · Cyprus Institute of Neurology and Genetics
University of Turin, Turin
Registry updated 2024-03-20

All Sickle cell disease trials and the map

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